HOME >> MEDICINE >> NEWS
Genetic test for cell-proliferation enzyme could improve treatment of acute lymphoblastic leukaemia

Authors of a Canadian research letter in this weeks issue of THE LANCET describe how genetic testing for an enzyme involved in cancer-cell proliferation could identify patients at an increased risk of poor outcome from acute lymphoblastic leukaemia.

The enzyme thymidylate synthase is associated with cell proliferation, and is therefore an important target for anticancer drugs, including the chemotherapeutic agent methotrexate. Maja Krajinovic from the University of Montreal, Canada, and colleagues investigated the possible association between a variant of the gene coding for thymidylate synthase(in which a specific triple repeat alteration is associated with increased expression of thymidylate synthase) and the outcome of acute lymphoblastic leukaemia in 205 children treated with methotrexate.

DNA samples from patients were analysed for variation by polymerase chain reaction (PCR) amplification. Children who were homozygous for the triple repeat were four times more likely to have a poorer outcome than children with other genotypes.

Maja Krajinovic comments: Thymidylate synthase genotype seems to be a significant predictor of outcome in childhood acute lymphoblastic leukaemia. This finding could lead to individualisation of treatment for patients with this disease.


'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-20-7424-4949
Lancet
21-Mar-2002


Page: 1

Related medicine news :

1. Genetics important in age-related macular degeneration
2. Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
3. Genetically targeted therapies create opportunities to do business in new ways
4. Genetic testing can identify ischemic and nonischemic heart failure
5. Genetics testing saves health care dollars
6. Genetic mutation linked to infant lung disease
7. Genetic switch proves two mechanisms exist by which immune system cells differentiate
8. Genetic risks for disease often missing from patient charts
9. Genetics of familial atrial fibrillation revealed, Science researchers report
10. Genetic variant may impact smoking cessation
11. Genetics in clinical practice: a revolutionary approach

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... August 15, 2019 , ... Heritage Woods of Rockford ... for Assisted Living (NCAL). , This award is part of the NCAL Awards Program, ... profession. , “The common element among this year’s recipients is that they all go ...
(Date:8/14/2019)... ... August 13, 2019 , ... New Hampshire-based Vera Roasting ... today announced an expansion of its line of CBD-infused coffees with the release of ... in a 12-oz bag. , “We are excited to expand our CBD-infused product ...
(Date:8/14/2019)... ... August 14, 2019 , ... Today, consumers are taking a harder look at ... physical body, emotions and energy levels. The trick is finding food and beverages that ... That’s why founder Chris Harper created Chase – a delicious, guilt free ...
(Date:8/12/2019)... ... August 12, 2019 , ... Injured veterans from across the ... the 4th annual Lockton Warfighter Sports Charity Challenge being held on September 9 ... in the event again this year will be fifty wounded warfighters and Craig ...
(Date:8/9/2019)... , ... August 09, 2019 , ... ... Lebanon, its second opioid treatment program (OTP) in Ohio. MedMark Lebanon will provide ... addiction. The clinic, located at 1521 Walmart Drive, is now accepting patients. ...
Breaking Medicine News(10 mins):
(Date:8/15/2019)... ... ... On Sunday, August 4th, volunteers from Bright Now!® Dental partnered ... South LA community. Six doctors joined with their dedicated support staff to provide underinsured ... at the South Gate Day of Giving. , Over 50 individuals were referred ...
(Date:8/14/2019)... ... August 14, 2019 , ... Cambria Solutions, Inc., ... Inc. Magazine’s Inc. 5000 list . The Inc. 5000 is the most prestigious ... for Cambria,” said Cambria CEO Robert Rodriguez. “We have a committed and expanding team ...
(Date:8/14/2019)... Fla. (PRWEB) , ... August 13, 2019 , ... ... the possible genetic roots of polycystic ovary syndrome (PCOS), one of the leading ... CARE: The IVF Center, notes that the new study also provides the first ...
Breaking Medicine Technology:
Cached News: