HOME >> MEDICINE >> NEWS
Genetic test for melanoma developed at UCSF

San Francisco - A genetic test to help pathologists identify melanoma, the most common type of skin cancer, has been developed by researchers at University of California, San Francisco, and may be available to pathology labs within a year.

The test, which detects chromosomal abnormalities that characterize cancerous skin cells, was described here, today (March 9), at the annual meeting of the International Society of Dermatopathology.

A skin mole that looks suspicious to a dermatologist is usually biopsied and examined under the microscope. But even with years of experience it's sometimes impossible to make a clear decision as to whether or not the mole is cancerous. And sadly, many melanoma cases slip through the screening process; according to some insurance carriers, these cases account for six percent of the money awarded each year in malpractice suits.

Because melanoma results when a cell's genetic machinery gets out of control, Philip LeBoit, MD, a professor of pathology at UCSF, and his colleagues began comparing chromosomes of normal skin cells with those of cancerous ones. In a test called comparative genomic hybridization, they labeled DNA from normal and cancerous cells with different fluorescent dyes, then used these to identify the changes in the cancer cell's chromosomes.

These experiments were conducted by Boris Bastian, MD, an assistant professor of dermatology, Dan Pinkel, PhD, a professor at the NCI-designated UCSF Comprehensive Cancer Center, and LeBoit.

Clear patterns have emerged in the first 100 cases that LeBoit and his colleagues have studied: 82 percent of melanoma tumors lack portions of the DNA normally found on one arm of chromosome 9, 63 percent are missing sections of chromosome 10, and 50 percent of tumors have extra DNA on chromosome 7. Cancer cells that are missing DNA have shut down certain genes on that chromosome and, similarly, extra DNA
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
8-Mar-2000


Page: 1 2

Related medicine news :

1. Genetics important in age-related macular degeneration
2. Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
3. Genetically targeted therapies create opportunities to do business in new ways
4. Genetic testing can identify ischemic and nonischemic heart failure
5. Genetics testing saves health care dollars
6. Genetic mutation linked to infant lung disease
7. Genetic switch proves two mechanisms exist by which immune system cells differentiate
8. Genetic risks for disease often missing from patient charts
9. Genetics of familial atrial fibrillation revealed, Science researchers report
10. Genetic variant may impact smoking cessation
11. Genetics in clinical practice: a revolutionary approach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic test for melanoma developed UCSF

(Date:11/24/2014)... November 24, 2014 Mental health ... day. They break up families, ruin careers, and ... hope for those that suffer,” says Hardy ... is showing that our specialized nutritional treatments can ... appear on “Mind Over Matter”, the premiere episode ...
(Date:11/24/2014)... Dr. Michael Kettel , a leading fertility expert ... to discuss egg freezing as a viable and increasingly accessible ... news recently, with new company benefits at Facebook and Apple ... “[The companies] see it as a way to take care ... Says Dr. Kettel. , Up until a few weeks ago, ...
(Date:11/23/2014)... The report, “Market Snapshot: Aesthetic ... - Asia-Pacific” provides quantitative analysis of the three ... invasive body contouring devices, non-invasive body contouring devices ... size data by revenue and volume over the ... Japan, South Korea, Australia and India. It uses ...
(Date:11/23/2014)... News) -- The holidays can be a challenge for ... trigger major meltdowns, an expert says. "Holidays with ... but when you have children with special needs, some ... professor at University of the Sciences in Philadelphia, said ... let your hosts or visitors know what special requirements ...
(Date:11/23/2014)... New York, NY (PRWEB) November 23, 2014 ... over the past month in a federal litigation involving ... over similar diabetes medications, Bernstein Liebhard LLP reports. ... that 566 claims over a class of Type 2 ... been filed in the U.S. District Court, Southern District ...
Breaking Medicine News(10 mins):Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 3Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 4
(Date:11/24/2014)...  Marta Rendon, MD, founder of the Rendon Center for ... FL and international key opinion leader in dermatology, was one of ... States to attend the international Aesthetic Experts Summit ... Here, at this gathering of over 600 physicians from 57 ... surgery experts from Asia and ...
(Date:11/24/2014)...  GlySens Incorporated announced today that it has been ... National Institute of Diabetes and Digestive and Kidney Diseases ... (NIH).  The grant is intended to support human clinical ... implantable glucose monitoring system.  Final preparations for launch of ... begin before the end of 2014. "We ...
(Date:11/23/2014)... Calif. , Nov. 23, 2014 Anthera ... that Paul F. Truex , President and Chief ... 2014 Annual Piper Jaffray Healthcare Conference. ... , at the Palace Hotel in New ... Pharmaceuticals Anthera Pharmaceuticals is a biopharmaceutical company ...
Breaking Medicine Technology:Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3GlySens Incorporated Awarded $2 Million Grant from the National Institutes of Health 2Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2
Cached News: