HOME >> MEDICINE >> NEWS
Genetic test for melanoma developed at UCSF

San Francisco - A genetic test to help pathologists identify melanoma, the most common type of skin cancer, has been developed by researchers at University of California, San Francisco, and may be available to pathology labs within a year.

The test, which detects chromosomal abnormalities that characterize cancerous skin cells, was described here, today (March 9), at the annual meeting of the International Society of Dermatopathology.

A skin mole that looks suspicious to a dermatologist is usually biopsied and examined under the microscope. But even with years of experience it's sometimes impossible to make a clear decision as to whether or not the mole is cancerous. And sadly, many melanoma cases slip through the screening process; according to some insurance carriers, these cases account for six percent of the money awarded each year in malpractice suits.

Because melanoma results when a cell's genetic machinery gets out of control, Philip LeBoit, MD, a professor of pathology at UCSF, and his colleagues began comparing chromosomes of normal skin cells with those of cancerous ones. In a test called comparative genomic hybridization, they labeled DNA from normal and cancerous cells with different fluorescent dyes, then used these to identify the changes in the cancer cell's chromosomes.

These experiments were conducted by Boris Bastian, MD, an assistant professor of dermatology, Dan Pinkel, PhD, a professor at the NCI-designated UCSF Comprehensive Cancer Center, and LeBoit.

Clear patterns have emerged in the first 100 cases that LeBoit and his colleagues have studied: 82 percent of melanoma tumors lack portions of the DNA normally found on one arm of chromosome 9, 63 percent are missing sections of chromosome 10, and 50 percent of tumors have extra DNA on chromosome 7. Cancer cells that are missing DNA have shut down certain genes on that chromosome and, similarly, extra DNA
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
8-Mar-2000


Page: 1 2

Related medicine news :

1. Genetics important in age-related macular degeneration
2. Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
3. Genetically targeted therapies create opportunities to do business in new ways
4. Genetic testing can identify ischemic and nonischemic heart failure
5. Genetics testing saves health care dollars
6. Genetic mutation linked to infant lung disease
7. Genetic switch proves two mechanisms exist by which immune system cells differentiate
8. Genetic risks for disease often missing from patient charts
9. Genetics of familial atrial fibrillation revealed, Science researchers report
10. Genetic variant may impact smoking cessation
11. Genetics in clinical practice: a revolutionary approach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic test for melanoma developed UCSF

(Date:10/31/2014)... 31, 2014 (HealthDay News) -- Sleep apnea may make it ... you parked your car or left your house keys, a ... sleep apnea showed that this ability -- called spatial memory ... (REM) sleep, even when other stages of sleep weren,t affected. ... dreams typically occur. "We,ve shown for the first time ...
(Date:10/31/2014)... Americans say that either they or a family member ... the latest issue of The Gerontological Society of America,s ... ), which goes on to show that Americans strongly ... patients, end-of-life health care wishes. , This PP&AR ... ," features 12 articles that present new ways of ...
(Date:10/31/2014)... 2014 North Shore Eye Care today ... Long Island and the addition of leading ophthalmologist, William ... to North Shore Eye Care Medical Director, Jeffrey Martin, ... of the Department of Ophthalmology of Winthrop-University Hospital and ... City for more than 30 years. He has been ...
(Date:10/31/2014)... York, NY (PRWEB) October 31, 2014 ... of the most remarkable gifts of life — building ... for matching extraordinary surrogate mothers and donors with hopeful ... individuals in unforeseen circumstances. , It’s a collective aptitude ... surrogacy agencies, surrogacy lawyers, and fertility clinics that help ...
(Date:10/31/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its new ... U.S. indoor air quality (IAQ) market is expected to grow ... rate (CAGR) of 7% over the next five years. The ... of 7.4%. , Since 2012, continuing media attention focused ... infectious diseases such as bird flu and the increase in ...
Breaking Medicine News(10 mins):Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Advance directives can benefit patients, families, and health care system 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 2Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 3Health News:Global Market for U.S. Indoor Air Quality (IAQ) to Reach $11.4 Billion by 2019; Equipment Market Segment Surging at 7.4% CAGR 2Health News:Global Market for U.S. Indoor Air Quality (IAQ) to Reach $11.4 Billion by 2019; Equipment Market Segment Surging at 7.4% CAGR 3
(Date:10/31/2014)... , Oct. 31, 2014 ThynkWare ( ... (ALS) patients initiate text and email messages using their ... patent-pending technology invented by ThynkWare,s founder, Duane Cash ... a smartphone device. This technology allows users to control ... the power of thought. ThynkWare provides the ...
(Date:10/31/2014)... Australia and BARCELONA , October ... Ltd (Multigate) was found to infringe two Australian patents of ... for sale in Australia safety IV ... 17.10.14 in Federal Court of Australia ... http://www.austlii.edu.au/au/cases/cth/FCA/2014/1110.html . In the detailed judgment, ...
(Date:10/31/2014)... , October 30, 2014 ... announced the addition of the  "Process Validation in ... their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... and Risk Based Approach to Process Validation for ... Management FDA Process Validation Guidance ...
Breaking Medicine Technology:ThynkWare Speech Helps Those with ALS and Locked-In Syndrome Translate Thought to Speech on Their Smartphone Devices 2B. Braun Wins Patent Disputes Against Poly Medicure Ltd's Australian Distributor Multigate Medical Devices Pty. Ltd. and Spanish Distributor Dextromédica S. L. 2Process Validation in the US and EU (Workshop, London) 2Process Validation in the US and EU (Workshop, London) 3Process Validation in the US and EU (Workshop, London) 4
Cached News: