HOME >> MEDICINE >> NEWS
Genetic test for melanoma developed at UCSF

San Francisco - A genetic test to help pathologists identify melanoma, the most common type of skin cancer, has been developed by researchers at University of California, San Francisco, and may be available to pathology labs within a year.

The test, which detects chromosomal abnormalities that characterize cancerous skin cells, was described here, today (March 9), at the annual meeting of the International Society of Dermatopathology.

A skin mole that looks suspicious to a dermatologist is usually biopsied and examined under the microscope. But even with years of experience it's sometimes impossible to make a clear decision as to whether or not the mole is cancerous. And sadly, many melanoma cases slip through the screening process; according to some insurance carriers, these cases account for six percent of the money awarded each year in malpractice suits.

Because melanoma results when a cell's genetic machinery gets out of control, Philip LeBoit, MD, a professor of pathology at UCSF, and his colleagues began comparing chromosomes of normal skin cells with those of cancerous ones. In a test called comparative genomic hybridization, they labeled DNA from normal and cancerous cells with different fluorescent dyes, then used these to identify the changes in the cancer cell's chromosomes.

These experiments were conducted by Boris Bastian, MD, an assistant professor of dermatology, Dan Pinkel, PhD, a professor at the NCI-designated UCSF Comprehensive Cancer Center, and LeBoit.

Clear patterns have emerged in the first 100 cases that LeBoit and his colleagues have studied: 82 percent of melanoma tumors lack portions of the DNA normally found on one arm of chromosome 9, 63 percent are missing sections of chromosome 10, and 50 percent of tumors have extra DNA on chromosome 7. Cancer cells that are missing DNA have shut down certain genes on that chromosome and, similarly, extra DNA
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
8-Mar-2000


Page: 1 2

Related medicine news :

1. Genetics important in age-related macular degeneration
2. Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
3. Genetically targeted therapies create opportunities to do business in new ways
4. Genetic testing can identify ischemic and nonischemic heart failure
5. Genetics testing saves health care dollars
6. Genetic mutation linked to infant lung disease
7. Genetic switch proves two mechanisms exist by which immune system cells differentiate
8. Genetic risks for disease often missing from patient charts
9. Genetics of familial atrial fibrillation revealed, Science researchers report
10. Genetic variant may impact smoking cessation
11. Genetics in clinical practice: a revolutionary approach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic test for melanoma developed UCSF

(Date:7/31/2014)... Dublin, Ohio (PRWEB) July 31, 2014 ... solutions for health care, announces the release of a “Twelve ... web seminar for hospitals that are evaluating Health Information Service ... 2. Hospitals that utilize MEDITECH and Epic electronic health ... order to exchange transitions of care using the Direct protocol. ...
(Date:7/31/2014)... 2014 A cancer diagnosis is crushing and ... and resume normal lives. This is particularly true of prostate ... one in seven American men but which when detected early, ... rate of nearly 100% and a ten-year survival rate of ... diagnosed with the disease do not die from it. There ...
(Date:7/31/2014)... its latest blog post, Best Drug Rehabilitation , which ... during a stay in rehab can make a big difference ... on nine secrets that addicts don’t want others to know. ... an addict from a mile away, and totally understand what’s ... Per Wickstrom . “However, take it from me: spotting ...
(Date:7/31/2014)... July 31, 2014 In its latest blog ... and believes that having family close by during a stay ... not the process is successful, is looking at 10 tips ... , “Addiction recovery is a lifelong process, and one ... be committed to without compromise,” commented Best Drug Rehabilitation’s CEO ...
(Date:7/31/2014)... Oregon (PRWEB) July 31, 2014 ... properties and digestibility, erythritol has long been used ... such as stevia and monk fruit. However consistent, ... In an effort to meet food and beverage ... sourcing, Steviva Ingredients has launched GMO-free ErysweetTM Erythritol. ...
Breaking Medicine News(10 mins):Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 2Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 4Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 2Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 3Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 4Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 3Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:Steviva Ingredients Launches Erysweet Erythritol 2
(Date:7/30/2014)... Calif. , July 30, 2014  El Camino ... improve patient care, is utilizing the Leaf Patient Monitoring ... the position and movement of patients susceptible to bed ... a six month-long, 138-patient study of the system, which ... turn protocols. Turning patients regularly is the one of ...
(Date:7/30/2014)... July 30, 2014  InnoPharma, Inc. today announced the ... generic equivalent of Zyprexa® injection), in Canada.  Olanzapine is ... behaviors in patients with schizophrenia or bipolar I mania. ... drug, InnoPharma has entered into an agreement with Sandoz ... will make, use, sell, market and distribute Olanzapine Injection ...
(Date:7/30/2014)... July 30, 2014 Cynosure, Inc. (NASDAQ: ... aesthetic treatments for non-invasive and minimally invasive applications, today announced ... Chief Operating Officer and Chief Financial Officer Timothy W. ... 2014.  Baker, 53, will continue to serve as CFO and ... , who remains Chairman and Chief Executive Officer. ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3InnoPharma Announces Launch of Olanzapine for Injection, 10mg/vial in Canada 2Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2
Cached News: