HOME >> MEDICINE >> NEWS
Genetic variant reduces immune response, yet protects against atherosclerosis

DURHAM, N.C. -- An international team led by Duke University Medical Center researchers has discovered that a genetic variant of an immune system receptor appears to simultaneously dampen the body's immune response to bacteria and other microbial toxins and to provide some protection against atherosclerosis, or clogging of the arteries. The scientists believe their discovery suggests a possible new approach to anti-atherosclerosis drugs.

The genetic variant, or polymorphism, occurs in one of a family of 10 receptors known collectively as "Toll-like receptors" (TLRs), reflecting the fact that the human receptors resemble Toll receptors first discovered in flies. These TLRs -- which are located on the surface of immune cells, heart muscle cells, airway epithelial cells and cells lining blood vessels -- are crucial to immune responses to bacteria. They recognize a specific lipid on the surface of bacteria and provide the first warning to the immune system that an invader is present. The researchers estimate that the polymorphism of the Toll-like receptor 4 (TLR4) they studied occurs in about 10 percent of the population.

"This particular polymorphism appears to attenuate the receptor signaling ability and to diminish the inflammatory response. Our results suggest that the diminished inflammatory response is responsible for a decreased risk of atherosclerosis," said Duke's David Schwartz, M.D., principal investigator for the study, the results of which were published today (July 18, 2002) in the New England Journal of Medicine. "We were quite encouraged that the data were so compelling in the degree to which this polymorphism is so protective.

"This represents a completely new mechanism involved in atherosclerosis and cardiovascular disease, and it provides a potential novel target for decreasing one's chances of developing heart disease," Schwartz continued. "In addition to using traditional means to reduce the risk of heart disease, such as ex
'"/>

Contact: Richard Merritt
merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
17-Jul-2002


Page: 1 2 3

Related medicine news :

1. Genetics important in age-related macular degeneration
2. Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
3. Genetically targeted therapies create opportunities to do business in new ways
4. Genetic testing can identify ischemic and nonischemic heart failure
5. Genetics testing saves health care dollars
6. Genetic mutation linked to infant lung disease
7. Genetic switch proves two mechanisms exist by which immune system cells differentiate
8. Genetic risks for disease often missing from patient charts
9. Genetics of familial atrial fibrillation revealed, Science researchers report
10. Genetic variant may impact smoking cessation
11. Genetics in clinical practice: a revolutionary approach

Post Your Comments:
(Date:7/31/2014)... 31, 2014 Reputation Management India, a ... service named ‘Remove Bad Reviews’. The service is for ... published on various review sites. , The company ... internet marketing, the sites that allow bad reviews, and ... to tailor the service. , About the service, ...
(Date:7/31/2014)... India (PRWEB) July 31, 2014 RankingBySEO, ... service for those individuals and organizations against whom negative ... as ‘Remove Negative Comments Service’. , About the ... “We have officially announced the service now, but we ... rid of negative comments for several years.” , On ...
(Date:7/31/2014)... Calif. and Las Vegas, Nevada (PRWEB) July 31, 2014 ... with LaunchKey to provide next generation authentication services to ... and secure way to utilize hardware protected multi-factor authentication ... problem in the Internet's reliance on password-based authentication. It ... and global data breaches taking place around the globe. ...
(Date:7/31/2014)... 2014 Thousands of independent community ... country have come together today to kick off ... tradeshow. , "ThoughtSpot 2014 is Good Neighbor Pharmacy’s ... tools to help their businesses thrive," stated AJ ... a long-standing commitment to independent community pharmacies, and ...
(Date:7/31/2014)... FITNESS SF, a growing chain of health ... upgrade all locations to Motionsoft’s full cloud-based ... is a leading provider of club management solutions, and ... payments services for health and wellness centers. MoSo is ... SF bundled with the MoSo Pay secure billing solution ...
Breaking Medicine News(10 mins):Health News:Reputation Management India Launches a New Service Called ‘Remove Bad Reviews’ 2Health News:RankingBySEO Launches a New Service ‘Remove Negative Comments’ 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 3Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 2Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 3Health News:FITNESS SF Upgrades Motionsoft Software to Include Entire Product Lineup: MoSo + MoSo Pay + MyClub 2
(Date:7/31/2014)... LONDON , July 31, 2014 ... for the medical industries, announced today the incorporation of genae UK ... United Kingdom has one of the largest medical device ... in 2012 and it is projected to increase by a CAGR ... billion in 2012, equal to 9.5% of GDP. Despite recessionary pressures, ...
(Date:7/31/2014)... For the first time, cardiac surgeons, medical ... the SynCardia temporary Total Artificial Heart in a peer ... the Journal of Visualized Experiments website. ... the SynCardia Total Artificial Heart implantation   goo.gl/2OZyKW ... the SynCardia Total Artificial Heart," a July 18, 2014 ...
(Date:7/31/2014)... AUSTIN, Texas , July 31, 2014 Vermillion, ... cancers and women,s health, will hold a conference call on ... discuss results for the second quarter ended June 30, 2014. ... to the call. Vermillion,s Chairman, President and CEO ... a question and answer period. Date: Thursday, August ...
Breaking Medicine Technology:genae Opens Offices in London 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2
Cached News: