HOME >> MEDICINE >> NEWS
Genetics of familial atrial fibrillation revealed, Science researchers report

This release is also available in traditional Chinese, simplified Chinese and Japanese.

Scientists have identified a genetic mutation causing the irregular heartbeats that characterize atrial fibrillation (AF). Nearly one out of every 20 individuals over age 65 suffer from this cardiac arrhythmia, which is increasing in prevalence as the population ages. When left unchecked, AF can lead to heart muscle dysfunction, embolism, ventricular arrhythmia, and heart failure. Studying families with a rare inherited form of AF, a collaborative research team composed of scientists in China and France has identified the disease-causing gene as KCNQ1, which encodes a protein subunit of an ion channel controlling the movement of charged potassium through a cell membrane. The discovery is reported in the 10 January 2003 issue of Science.

This new understanding of the molecular basis of atrial fibrillation may lead to better pre-symptomatic diagnosis of the disorder and to the development of new therapies, according to corresponding authors, Yi-Han Chen of Tongji University, Shanghai, China and Shi-Jie Xu of Chinese National Human Genome Center, Shanghai, China.

The scientists studied a four-generation family in China with a history of AF. Of the 44 living members of this family from both rural villages and nearby cities in northern Shandong Province, sixteen have cases of AF, all of which the researchers confirmed were hereditary. Gene mapping studies led the researchers to the critical region of chromosome 11 that was linked to AF. Sequence analysis revealed that there was a specific nucleotide substitution in the KCNQ1 gene in all of the family members affected with
'"/>

Contact: Lisa Onaga
Lonaga@aaas.org
202-326-7088
American Association for the Advancement of Science
9-Jan-2003


Page: 1 2 3

Related medicine news :

1. Genetics important in age-related macular degeneration
2. Genetics testing saves health care dollars
3. Genetics in clinical practice: a revolutionary approach
4. Genetics likely to be a major factor in osteoarthritis of the hip
5. Fred Hutchinson Cancer Research Center And Targeted Genetics Corp. Publish Data On Adoptive Immunotherapy For HIV
6. Researchers find strong familial tendency in rare form of lymphoma
7. Nitric oxide links bulk of sporadic and familial Parkinsons disease
8. Animal study shows link between nicotine and atrial flutter
9. Obesity appears to be modifiable risk factor for atrial fibrillation
10. Study clarifies impact of age on safety of warfarin treatment for atrial fibrillation
11. New research in atrial fibrillation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: