Genital ulcers increase during and after HIV infection

cent of those with HIV had genital ulcers compared to 6.3 percent of those without HIV. By the third visit, the genital ulcer rates were 11.6 percent for the HIV-positive group and 6.7 percent for the HIV-negative group.

Further analysis showed that the increase in genital ulcer disease among HIV-positive participants in the study was associated with the presence of HSV-2 antibodies. After HIV acquisition, the HIV viral loads increased among those with the herpes virus compared to those without. "People with increased HIV viral loads become more infectious to others and the increased viral loads can increase the progression to AIDS. We must conduct randomized trials to determine whether treatment and suppression of herpes in HIV-infected people can reduce genital ulceration, HIV viral levels and possibly transmission of HIV," said Dr. Gray.


Contact: Tim Parson
Johns Hopkins University Bloomberg School of Public Health

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