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Genomics research: New genetic 'hit list' may underlie susceptibility to sudden cardiac death

rol subjects. Yet this study showed that Q9E-MiRP1 is present in about five percent of blacks and therefore could predispose thousands of minority individuals to drug-induced sudden death.

Previous study methods would have inappropriately labeled nearly all 36 newly-identified variants as disease-causing mutations. More research must be done to determine if the higher frequency of channel variants indicates an increased risk for fatal arrhythmias.

Co-authors of the article include David Tester and Melissa Will, Mayo Clinic, and Christopher Burrow, M.D., Mark Curran, Ph.D., and Gregg Jones, formerly of DNA Sciences, Inc., Fremont, Calif.

Mayo Clinic conducts research in medical genomics and proteomics in order to improve patient care. Its scientists and clinical investigators strive to turn laboratory discoveries into beneficial therapies as quickly as possible. Patient privacy and confidentiality in research studies are ensured.


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Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
30-Dec-2003


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