HOME >> MEDICINE >> NEWS
Genotyping targets individuals at high risk for H. pylori-associated stomach cancer

A new study indicates that people carrying certain strains of the Helicobacter pylori bacterium who also have specific genetic polymorphisms are more likely to develop stomach cancer than others. The findings appear in the November 20 issue of the Journal of the National Cancer Institute.

People infected with H. pylori have an increased risk of stomach cancer, but many of these people will never develop the disease. Past studies have suggested that disease progression depends on a number of factors, including the bacterial strain and genetic variations in the host.

To determine whether certain combinations of bacterial and host genotypes increase the risk of stomach cancer, Cu Figueiredo, Ph.D., of the Institute of Molecular Pathology and Immunology at the University of Porto in Portugal, and colleagues examined 221 people with chronic gastritis and 222 people with stomach cancer.

The authors found that certain combinations of bacterial and host genotypes were strongly associated with the risk of stomach cancer. For example, people carrying a high-activity version of interleukin-1 beta gene who were infected by an H. pylori strain with a particular variant of the vacA vacuolating cytotoxin had a nearly 90-fold increase in the risk of stomach cancer.

"Our findings indicate that H. pylori and host genotyping can be important in better defining disease risk and preferentially targeting H. pylori eradication to high-risk individuals," the authors conclude.

In an accompanying editorial, Martin Blaser, M.D., of the New York University School of Medicine, says that these findings are promising, but he cautions that it still too early to generalize from this work.

"The study needs confirmation, different ethnic groups must be examined, the technique must be simplified for general use, and our understanding of the risks and benefits of H. pylori must grow," he writes. "Nevertheless, assessing risk for gastric disea
'"/>

Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Nov-2002


Page: 1 2

Related medicine news :

1. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
2. NHS stop-smoking services are insufficient to deliver national smoking targets
3. Burning anxiety: New treatment targets smokers with panic disorder
4. Technology points to possible targets for epilepsy and Alzheimers drugs
5. $5 million grant awarded to U.VA health system targets leukemia drug development, creates new jobs
6. Research targets biologic profile of obesity
7. SSX, a new family of cancer vaccine targets
8. 2005 global tuberculosis targets may be out of reach
9. One drug, two targets
10. Schools culture of testing and targets squeezes support for at risk youngsters
11. Marijuana-derived compound targets pain, inflammation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... 2020 , ... International Dark-Sky Association (IDA) recently bestowed the ... This advanced LED wireless dimming controller, along with the previously IDA approved Dimulator, ... against light pollution. Leo Smith, the Northeast Regional Director for IDA says “We ...
(Date:9/1/2020)... MESA, Calif. (PRWEB) , ... September 01, 2020 , ... ... the “safe side”, the Cohn Health Institute has taken this time to ... In celebration of its 30th Anniversary, the Cohn Health Institute will be relaunching its ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical ... medical first responders across the United States. Since the start of the global ... (PPE) medical centers , hospitals , firefighters , and ...
(Date:8/31/2020)... ... ... The pandemic and topsy-turvy economic outlook continues to put financial strain on many of us, ... the fat from our monthly expenses and put more into savings, if possible. , “That’s ... a financial safety net in place in case something were to happen to you,” says ...
(Date:8/29/2020)... (PRWEB) , ... August 29, 2020 , ... When professor ... perhaps with greater ease than most people would. Rather than become melancholic, however, he ... deep advice on achieving one’s dreams. Randy Pausch took a negative situation and turned ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... ... As the U.S. struggles in its 6th month of fighting Covid-19, Americans are ... keep your distance, wash your hands. Prevention is the best tool for now. Noted ... much better it is to prevent disease than to cure it.” , Part of ...
(Date:8/26/2020)... CORONA, Calif. (PRWEB) , ... August 26, 2020 , ... ... production to a target goal of 115 million 3 ply surgical disposable face masks ... The production is in direct response to the challenge that most Americans are facing ...
(Date:8/26/2020)... ... August 26, 2020 , ... NucleusHealth, LLC, a ... Hooton as President and Chief Executive Officer effective immediately. Dr. Vishal Verma, the ... Board of Managers. , Mr. Hooton, a seasoned business executive, joined the ...
Breaking Medicine Technology:
Cached News: