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Global study shows new breast cancer drug extends patients' overall survival

NEW ORLEANS- Breast cancer patients with advanced disease live longer when treated with a new drug, gemcitabine, in combination with paclitaxel, a traditional drug, according to results of a landmark global phase III study presented today at the American Society of Clinical Oncology (ASCO) annual meeting.

"Improved overall survival demonstrates that gemcitabine with paclitaxel should be a standard frontline regimen in treating breast cancer that has spread," said principal investigator and first author Dr. Kathy S. Albain, professor, division of hematology/oncology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Ill.

Albain designed and chaired this international trial that directly resulted in the FDA's very recent approval of gemcitabine for breast cancer. In previous years, the FDA has approved gemcitabine for other cancers. The drug disrupts cell replication by incorporating itself directly into the DNA.

The research applies to women who have never had chemotherapy for their advanced breast cancer but were already exposed to the anticancer class of drugs known as anthracyclines when their breast cancer was first diagnosed in an early stage.

Participating in the study were 529 patients randomized at 98 sites in 19 countries. The study compared gemcitabine plus paclitaxel to paclitaxel alone in women with metastatic breast cancer.

A total of 267 patients (median age: 53 years) received gemcitabine plus paclitaxel; another 262 patients (median age: 52 years) received paclitaxel alone. Albain reported that median overall survival was 18.5 months for gemcitabine with paclitaxel, and 15.8 months for paclitaxel alone.

"One year survival was 71 percent in the group that received the combination therapy, compared to 61 percent for the group treated with paclitaxel alone," said Albain, director, Breast
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Contact: Joanne Swanson
jswanson@lumc.edu
708-216-2445
Loyola University Health System
5-Jun-2004


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