HOME >> MEDICINE >> NEWS
Glutathione depletion in chronic alcohol abuse makes lungs vulnerable to life-threatening diseases

Chronic alcohol abuse causes a profound deficiency of the antioxidant glutathione in the lungs, generating a marked susceptibility to serious lung diseases, according to research at Emory University School of Medicine and the Atlanta Veterans Affairs Medical Center.

Lowered glutathione levels can be as deadly to the lungs of alcohol abusers as alcohol itself can be to their livers and other organs, says David Guidot, M.D., associate professor of medicine at Emory University School of Medicine. Dr. Guidot will explain how glutathione depletion affects the lungs at a symposium on the cellular effects of chronic alcohol abuse at the Experimental Biology 02 meeting in New Orleans on April 24.

Until six years ago, when Emory scientist Marc Moss, M.D., first identified the connection between alcohol abuse and lung damage, scientists had not associated the two, even though alcohols ill effects on the liver, brain and other organs was well recognized, according to Dr. Guidot, "We now know that as many deaths occur every year from alcohol abuse related to lung injury as occur from alcohol abuse and liver disease or alcohol abuse and traffic accidents," he notes. Scientists previously had not focused on the connection between alcohol and lung disease because the cause-and-effect relationship is indirect, unlike the direct effect of alcohol on the liver, explains Dr. Guidot. Dr. Guidot began studying the effects of glutathione depletion on the lungs while reviewing the mechanisms of alcohol toxicity in other organs. The body manufactures glutathione a strong anti-oxidant molecule from amino acids, which are the building blocks of proteins. Individuals with reasonably good diets maintain an adequate supply of glutathione, which is constantly being used up and replenished.

Although glutathione is manufactured in a variety of organs and tissues, including the liver, the lungs are particularly dependent on glutathione for protection from oxidati
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
24-Apr-2002


Page: 1 2

Related medicine news :

1. UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
2. UMaine study looks at infants and chronic nighttime crying
3. Study finds that coordinating care of chronically ill patients does not increase liability
4. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
7. Activity not out of the question for people with chronic pain
8. Generation gap found in chronic pain
9. No advantage of combination drug therapy for chronic hepatitis B Infection
10. Few Americans are aware they have chronic kidney disease
11. Few Americans aware they have chronic kidney disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... (PRWEB) , ... September 20, ... ... a software company specializing in medical device compliance and commercialization, has just ... risk management activities. , FDA is more adamant than ever about medical ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... innovation, the company recently unveiled a redesigned website. The new site – still ... of building owners, architects, contractors and other industry users that Garland serves. , ...
(Date:9/20/2017)... ... September 20, 2017 , ... The ... “Humans With Vaginas.” The goal is to ignite conversation via social media and ... products. The brand has declared September “Humans with Vaginas” month, releasing a video ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... Health & ... and 30-Hour and HAZWOPER 8-, 24- and 40-Hour courses from now until November 30, ... In addition to offering these discounted prices to all businesses and government agencies – ...
(Date:9/20/2017)... ... 20, 2017 , ... “Finn Mouseson”: follows the exciting story of a mouse ... mouse sets out on a journey that will show that friends are to be ... newly published author and illustrator, Melody Gersonde-Mickelson, who has earned a bachelor’s degree in ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... , Sept. 5, 2017  Xyntek Inc. has announced another milestone in their ... Midwest office to meet the growing demands of customer engagements regionally.  ... Xyntek's new Midwest office is located at 318 West Adams ... ... engagements regionally. ...
(Date:9/5/2017)... 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral drug ... its meeting with the U.S. Food and Drug Administration ... At the meeting, ... for submission of ORMD-0801, would be a Biologics License ...
(Date:9/1/2017)... will present the latest research from across its growing oncology ... Congress, September 8-12 in Madrid, Spain . ... on Bayer,s marketed portfolio and late-stage compounds as well as ... "We value the opportunity to meet with ... said Carsten Brunn , Head of Pharmaceuticals, Americas Region ...
Breaking Medicine Technology:
Cached News: