HOME >> MEDICINE >> NEWS
Glutathione depletion in chronic alcohol abuse makes lungs vulnerable to life-threatening diseases

Chronic alcohol abuse causes a profound deficiency of the antioxidant glutathione in the lungs, generating a marked susceptibility to serious lung diseases, according to research at Emory University School of Medicine and the Atlanta Veterans Affairs Medical Center.

Lowered glutathione levels can be as deadly to the lungs of alcohol abusers as alcohol itself can be to their livers and other organs, says David Guidot, M.D., associate professor of medicine at Emory University School of Medicine. Dr. Guidot will explain how glutathione depletion affects the lungs at a symposium on the cellular effects of chronic alcohol abuse at the Experimental Biology 02 meeting in New Orleans on April 24.

Until six years ago, when Emory scientist Marc Moss, M.D., first identified the connection between alcohol abuse and lung damage, scientists had not associated the two, even though alcohols ill effects on the liver, brain and other organs was well recognized, according to Dr. Guidot, "We now know that as many deaths occur every year from alcohol abuse related to lung injury as occur from alcohol abuse and liver disease or alcohol abuse and traffic accidents," he notes. Scientists previously had not focused on the connection between alcohol and lung disease because the cause-and-effect relationship is indirect, unlike the direct effect of alcohol on the liver, explains Dr. Guidot. Dr. Guidot began studying the effects of glutathione depletion on the lungs while reviewing the mechanisms of alcohol toxicity in other organs. The body manufactures glutathione a strong anti-oxidant molecule from amino acids, which are the building blocks of proteins. Individuals with reasonably good diets maintain an adequate supply of glutathione, which is constantly being used up and replenished.

Although glutathione is manufactured in a variety of organs and tissues, including the liver, the lungs are particularly dependent on glutathione for protection from oxidati
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
24-Apr-2002


Page: 1 2

Related medicine news :

1. UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
2. UMaine study looks at infants and chronic nighttime crying
3. Study finds that coordinating care of chronically ill patients does not increase liability
4. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
7. Activity not out of the question for people with chronic pain
8. Generation gap found in chronic pain
9. No advantage of combination drug therapy for chronic hepatitis B Infection
10. Few Americans are aware they have chronic kidney disease
11. Few Americans aware they have chronic kidney disease

Post Your Comments:
(Date:1/22/2015)... Minn. (PRWEB) January 22, 2015 Blue Cross ... those Minnesotans who exemplify what it means to “Live Fearless.” ... chance for people to share their stories about how they ... or simply inspired others by living in the moment. By ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Juvent Sports ... at the 2015 PGA Merchandise Show to bestow a ... incredible female amateur golfer, Arlene McKitrick. The award commemorated ... amateur golf tournament win. She won her first amateur ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Joan Lunden, ... keynote speaker at the upcoming 32nd Annual Miami ... Physicians’ Education Resource®, LLC (PER®) , shares that ... have gone undetected if she had not followed up ...
(Date:1/22/2015)... January 23, 2015 Recently, Weddingshe.com has added ... and has announced its highest annual revenues in the past ... its popular glamorous wedding dresses. , According to the sales ... wedding dress promotions for them in 2015. This point can ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
(Date:1/22/2015)... 2015  ResMed Inc. (NYSE: RMD ) today announced ... the quarter was $423.0 million, a 10 percent increase compared ... increase on a constant currency basis). Net income was $91.2 ... ended December 31, 2013. Diluted earnings per share for the ...
(Date:1/22/2015)... 2015  Profil Institute for Clinical Research, Inc., a clinical ... today a new textbook,  Translational Research Methods for Diabetes, ... leading global scientific publisher. The textbook is ... use in early phase clinical studies of new drugs ...
(Date:1/22/2015)... ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the addition of ... by End User - Global Forecast to 2019" report ... market is valued at $1,228.58 million in 2014 and is ... $2,230.72 million by 2019. Allergy diagnostics is used to determine ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
Cached News: