HOME >> MEDICINE >> NEWS
Glutathione depletion in chronic alcohol abuse makes lungs vulnerable to life-threatening diseases

Chronic alcohol abuse causes a profound deficiency of the antioxidant glutathione in the lungs, generating a marked susceptibility to serious lung diseases, according to research at Emory University School of Medicine and the Atlanta Veterans Affairs Medical Center.

Lowered glutathione levels can be as deadly to the lungs of alcohol abusers as alcohol itself can be to their livers and other organs, says David Guidot, M.D., associate professor of medicine at Emory University School of Medicine. Dr. Guidot will explain how glutathione depletion affects the lungs at a symposium on the cellular effects of chronic alcohol abuse at the Experimental Biology 02 meeting in New Orleans on April 24.

Until six years ago, when Emory scientist Marc Moss, M.D., first identified the connection between alcohol abuse and lung damage, scientists had not associated the two, even though alcohols ill effects on the liver, brain and other organs was well recognized, according to Dr. Guidot, "We now know that as many deaths occur every year from alcohol abuse related to lung injury as occur from alcohol abuse and liver disease or alcohol abuse and traffic accidents," he notes. Scientists previously had not focused on the connection between alcohol and lung disease because the cause-and-effect relationship is indirect, unlike the direct effect of alcohol on the liver, explains Dr. Guidot. Dr. Guidot began studying the effects of glutathione depletion on the lungs while reviewing the mechanisms of alcohol toxicity in other organs. The body manufactures glutathione a strong anti-oxidant molecule from amino acids, which are the building blocks of proteins. Individuals with reasonably good diets maintain an adequate supply of glutathione, which is constantly being used up and replenished.

Although glutathione is manufactured in a variety of organs and tissues, including the liver, the lungs are particularly dependent on glutathione for protection from oxidati
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
24-Apr-2002


Page: 1 2

Related medicine news :

1. UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
2. UMaine study looks at infants and chronic nighttime crying
3. Study finds that coordinating care of chronically ill patients does not increase liability
4. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
7. Activity not out of the question for people with chronic pain
8. Generation gap found in chronic pain
9. No advantage of combination drug therapy for chronic hepatitis B Infection
10. Few Americans are aware they have chronic kidney disease
11. Few Americans aware they have chronic kidney disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/21/2017)... ... July 21, 2017 , ... ... years, researchers from the Multicenter Orthopaedics Outcome Network (MOON) demonstrated that patients could ... after surgery, though activity levels decline over time. The study, presented today at ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... why concussion rates are on the rise, say researchers presenting their work at ... Toronto, Ontario, Canada. , “The combination of evaluating the patterns of change in ...
(Date:7/20/2017)... ... 2017 , ... ChenMed , a leading provider of value-based care for ... as Richmond Chief Medical Officer. Dr. McCarter, formerly Associate Professor of Family ... of Ambulatory Services for the UVA Health System, brings 30 years of highly relevant ...
(Date:7/20/2017)... NY, July 20, 2017 (PRWEB) , ... ... ... Nastel Technologies, a global provider of enterprise-grade IT operations analytics and application ... arm of one of world’s largest healthcare services providers. , According to ...
(Date:7/20/2017)... ... July 20, 2017 , ... For individuals with extended ... The adjustable beds used in such facilities are specially designed to accommodate patients with ... support. , An inventor from Rochester, Ind., has invented the patent-pending PORTABLE ARM ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ... a clinical-stage pharmaceutical company focused on the development of oral ... from the Israel Securities Authority to dual-list its common stock ... will commence trading on the TASE on July 12, 2017 ... of the Company, it is expected that Oramed will be ...
(Date:7/5/2017)... Wash. , July 5, 2017   BioLife ... leading developer, manufacturer and marketer of proprietary clinical grade ... cryopreservation freeze media ("BioLife"), today announced that it ... its debt holder and largest shareholder, to modify its ... Pursuant to the modification, WAVI agreed to exchange ...
(Date:6/30/2017)... In vitro diagnostics market firm Kalorama Information ... least ten diagnostic companies have successfully completed financings.  The ... a loan facility.  The size of these financings ranged ... Information provides a monthly IVD Market Trends Report ... "Diagnostics deals ...
Breaking Medicine Technology:
Cached News: