HOME >> MEDICINE >> NEWS
Glutathione depletion in chronic alcohol abuse makes lungs vulnerable to life-threatening diseases

Chronic alcohol abuse causes a profound deficiency of the antioxidant glutathione in the lungs, generating a marked susceptibility to serious lung diseases, according to research at Emory University School of Medicine and the Atlanta Veterans Affairs Medical Center.

Lowered glutathione levels can be as deadly to the lungs of alcohol abusers as alcohol itself can be to their livers and other organs, says David Guidot, M.D., associate professor of medicine at Emory University School of Medicine. Dr. Guidot will explain how glutathione depletion affects the lungs at a symposium on the cellular effects of chronic alcohol abuse at the Experimental Biology 02 meeting in New Orleans on April 24.

Until six years ago, when Emory scientist Marc Moss, M.D., first identified the connection between alcohol abuse and lung damage, scientists had not associated the two, even though alcohols ill effects on the liver, brain and other organs was well recognized, according to Dr. Guidot, "We now know that as many deaths occur every year from alcohol abuse related to lung injury as occur from alcohol abuse and liver disease or alcohol abuse and traffic accidents," he notes. Scientists previously had not focused on the connection between alcohol and lung disease because the cause-and-effect relationship is indirect, unlike the direct effect of alcohol on the liver, explains Dr. Guidot. Dr. Guidot began studying the effects of glutathione depletion on the lungs while reviewing the mechanisms of alcohol toxicity in other organs. The body manufactures glutathione a strong anti-oxidant molecule from amino acids, which are the building blocks of proteins. Individuals with reasonably good diets maintain an adequate supply of glutathione, which is constantly being used up and replenished.

Although glutathione is manufactured in a variety of organs and tissues, including the liver, the lungs are particularly dependent on glutathione for protection from oxidati
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
24-Apr-2002


Page: 1 2

Related medicine news :

1. UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
2. UMaine study looks at infants and chronic nighttime crying
3. Study finds that coordinating care of chronically ill patients does not increase liability
4. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Study finds new designer drug is potent treatment for chronic myelogenous leukemia
7. Activity not out of the question for people with chronic pain
8. Generation gap found in chronic pain
9. No advantage of combination drug therapy for chronic hepatitis B Infection
10. Few Americans are aware they have chronic kidney disease
11. Few Americans aware they have chronic kidney disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: ... and sells medical devices and wearable sleep respiratory products ... cooperation agreement with Hongyuan Supply Chain Management Co., Ltd. ... 20, 2016, to develop Dehaier,s new Internet medical technology ... will leverage Hongyuan Supply Chain,s sales platform to reach ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology:
Cached News: