Gout drug shows promise in treating chronic heart failure

DALLAS, June 18 A drug used to treat gout improves blood vessel function in heart failure patients, possibly by blocking the creation of harmful free radicals, researchers report in today's rapid access issue of Circulation: Journal of the American Heart Association.

"These results are the first to show that treatment with allopurinol can improve vessel dilation in heart failure patients," says Allan D. Struthers, M.D., F.R.C.P., co-author of the study and professor of cardiovascular medicine and therapeutics at Ninewells Hospital and Medical School, Dundee, United Kingdom. "The data are particularly noteworthy because allopurinol is often prescribed anyway in heart failure patients, although for other reasons. It is safe and relatively cheap."

Chronic heart failure (HF), in which the heart cannot pump enough blood to meet the body's needs, is a common condition that causes death and disability. People with HF often experience chest pain and breathlessness when they are physically active because oxygen-rich blood from the lungs backs up in the veins between the lungs and the heart instead of reaching the organs that need it. Fluid also builds up in other parts of the body, such as the ankles, he says.

In people with HF, the vessels fail to relax, forcing the failing heart to work even harder. The diuretic drugs used to treat the fluid retention of heart failure can result in gout, a buildup of uric acid in the blood. Gout occurs when excess uric acid is converted to sodium urate crystal and deposits in joints and other tissues, often in the big toe. Hence, the need for allopurinol, Struthers explains.

HF is also linked to oxidative stress, an increase in harmful free radicals that can damage blood vessels. The free radical superoxide is a form of oxygen that neutralizes nitric oxide, a substance created by the endothelium (the inner lining of the arteries) that dilates healthy vessels to accommodate increased demands during

Contact: Carole Bullock
American Heart Association

Page: 1 2 3

Related medicine news :

1. Study shows promise in identifying kidney failure
2. Study shows patch therapy may be as effective as oral medications
3. Study shows soy is well accepted in school lunches
4. Chronic pain treatments more effective when taken together, new study shows
5. UW study shows blacks and Latinos are more satisfied with physicians of the same race
6. Vaccine against childhood pneumonia shows promise
7. UW research shows risk factors for relapse among health care professionals who abuse drugs
8. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
9. New technique shows promise for improved straightening of crooked nose
10. Chemical decoy shows promise for slowing Alzheimers by acting as decoy
11. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... The growing adoption ... of Fall 2020 Virtual Conference, a two-day virtual event for radiology professionals that ... Beyond" is the follow-up to AuntMinnie.com's successful virtual event in spring 2020, in ...
(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, Inc., the perennial ... and Special Needs plans, is proud to support the 2020 National Conferences on ... is supporting the event as a sponsor and exhibitor and will be showcasing ...
(Date:9/1/2020)... ... 2020 , ... As fall and winter swiftly approach and many businesses cut ... taken this time to expand and grow into a full-fledged natural health clinic over ... will be relaunching its brand new website, expanding its services menu and has recruited ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Just found out your dear friend has ... heartbreaking when your friend or family member shares their diagnosis. Once the shock wears off, ... say the wrong thing? What are the best ways to help? Words are failing me. ...
(Date:8/31/2020)... ... 2020 , ... Colorado State University Global (CSU Global) – ... education – is proud to announce its new master’s degree in Military ... in the nation, the 60-credit hour program is designed to provide students with ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... Md. (PRWEB) , ... September 03, 2020 , ... ... National Sickle Cell Awareness Month in September by holding a series of events ... designated by Congress to focus attention on the need for research and treatment ...
(Date:9/3/2020)... ... 2020 , ... Q&J Face Masks announced today that the ... engineering lab, conducted tests on Q&J’s personal face mask that indicated the Q&J ... masks. Q&J face masks have both mechanical filtering and electrostatic filtering which are ...
(Date:9/3/2020)... ... September 03, 2020 , ... Using Analysis of Variance — A Practical ... 2020, 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/anova , How much would it help ... one can’t become one in 90 minutes, one can master a powerful statistical technique ...
Breaking Medicine Technology:
Cached News: