d into the subjects' plasma and that their phosphatidylcholine hydroperoxide (PC-OOH, a recognized marker of oxidative injury of plasma lipoproteins) levels were lowered as well. Plasma lipoprotein oxidation is generally recognized to be an important step in the formation of atherosclerotic plaques and subsequent cardiovascular disease, so lowered PC-OOH levels suggest a lowered risk of cardiovascular disease.

Miyazawa said two methodologies previously tested by his group allowed for a highly sensitive as well as a highly selective way to determine both plasma catechin and lipid peroxide levels, and that the findings certainly merit further consideration and study, given the worldwide prevalence of cardiovascular disease.

Miyazawa's study colleagues were: Kiyotaka Nakagawa, also of the Tohoku University Graduate School of Life Science and Agriculture; Manabu Ninomiya, Tsutomu Okubo, Nobuyuki Aoi, Lekh Raj Juneja, and Mujo Kim of the Taiyo Kagaku Company; and, Kenji Yamanaka, of the Sasakawa Clinic of Gastroenterology.

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Contact: Mary Stanik
m_stanik@acs.org
202-872-4065
American Chemical Society
12-Oct-1999

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