Growing blood vessels around clots in leg arteries may treat painful walking

DURHAM, N.C. - Like hearts, legs can also suffer from "attacks" when too little blood flows through clogged and narrowed arteries. And like angina in a heart, this lack of oxygen-rich blood to muscles that need it produces pain. Leg by-pass surgery and angioplasty can help some patients, but most people with leg clots walk as little as possible to avoid the pain.

Now, a novel therapy is being tested to treat this condition, known medically as "intermittent claudication." Researchers are using an "angiogenesis growth factor" to create new blood vessels around clogged leg arteries. Tests of these factors in heart disease have been ongoing, but this trial, led by physicians from Duke University Medical Center and the University of Michigan, is by far the largest study of angiogenesis in leg arteries.

The biologic drug being studied, called recombinant basic fibroblast growth factor (rFGF-2), has the potential to promote the growth of blood vessels around blockages, said Duke cardiologist Dr. Brian Annex.

"Potentially, this investigational drug may increase blood flow to the legs, which would increase exercise capacity and improve patients' quality of life," Annex said. He added that use of such angiogenesis factors in the legs "may even be more straightforward than in the heart where the circulation and delivery can be more complicated."

Annex and co-principal investigator, Dr. Robert Lederman, from Michigan, are organizing a 22-hospital, 180-patient trial that is randomized and placebo controlled. That means that neither the patients nor the physicians involved know who is receiving the drug or a "dummy" substance delivered twice, one month apart, by injection into arteries in both legs near the patient's hipbone.

Chiron Corp., makers of rFGF-2, is funding the Phase II clinical trial, which is being dubbed "TRAFFIC" - Therapeutic Angiogenesis with FGF For Intermittent Claudication. The study is bein

Contact: Renee Twombly
Duke University Medical Center

Page: 1 2

Related medicine news :

1. Growing your own replacement teeth? Not science fiction!
2. Growing epidemic of wet AMD ushers in new era in treatment of the disease
3. Americas teens: Growing up and out
4. Growing evidence that commonly used medicines may delay or prevent Alzheimers disease
5. Growing new blood vessels with a timed-release capsule of growth factor is a promising treatment for heart bypass patients, finds NHLBI study
6. Do Neurons Learn By Growing Thorns? Emergence Of Dendritic Spines Is Associated With Long-Term Synaptic Plasticity
7. Growing Younger By Keeping Up Regular Physical Activity
8. Acceptability Of Alternative Health Care Growing In U.S.
9. A marker for new blood vessel formation in tumors
10. Acupuncture found to lower elevations in blood pressure
11. Diagnostic test for range of blood disorders on the horizon

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: