Guidelines assessing outcome following radiation treatment and hormones overestimate progression

SALT LAKE CITY, UTAH--A new study from Fox Chase Cancer Center, Philadelphia, Pa., demonstrates that the current guidelines for assessing treatment outcome following radiation therapy overestimates progression when hormone therapy is added. The study results were presented today by Mark Buyyounouski, M.D., a resident in Fox Chase Cancer Center's department of radiation oncology, at the 45th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Salt Lake City, Utah.

Hormone therapy, or androgen deprivation, is commonly combined with radiation therapy to treat prostate cancer patients who have an intermediate or high risk of recurrence. Biochemical failure, or disease progression evidenced only by an elevated or rising PSA, is a useful early measure of prostate cancer treatment outcome for physicians. The ASTRO consensus definition of biochemical failure was tested in this study to determine its usefulness following the combined treatment regimen.

"Biochemical failure is declared, meaning there is high probability of future rises in PSA, if a patient has three consecutive rises in post-treatment PSA levels following treatment," explained Buyyounouski. "Upon the completion of hormone therapy, PSA levels rise modestly. However, not all patients will experience continued rises in the years following treatment. Approximately 20 to 30 percent will have three consecutive rises constituting biochemical failure but will not experience continued rises in later years following radiation therapy with androgen deprivation.

"Additional study is required to determine the ideal definition of biochemical failure that most accurately predicts for future progression of disease. Hopefully, improvements in the definition of biochemical failure will further aid physicians is counseling patients about selecting the most appropriate treatment."

Other study authors include Alexandra L. Hanlon, Ph.D., and Alan Pollack, M.D., Ph

Contact: Karen Carter Mallet
Fox Chase Cancer Center

Page: 1 2

Related medicine news :

1. ESC releases the first European Guidelines on Percutaneous Coronary Interventions (PCI)
2. Guidelines restricting endoscopy referrals put patients at risk
3. Guidelines for following pediatric cancer survivors aim to reduce medical complications
4. Guidelines issued for metabolic complications related to HIV & antiretrovirals
5. Guidelines do not prevent deliberate self harm
6. Guidelines lacking for patients hospitalized for heart failure
7. Guidelines needed to prevent spread of infection in European hospitals
8. Guidelines recommend EEG to evaluate childrens first nonfebrile seizure
9. Mayo Clinic Cardiologist Available To Discuss New Guidelines On Treatment Of Stable Angina
10. American Psychiatric Association Plans First Comprehensive Guidelines For HIV/AIDS Treatment
11. Newly Updated HIV Treatment Guidelines For Adults And Adolescents Available On The World Wide Web

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: