HOME >> MEDICINE >> NEWS
HIV-1 protease inhibitors: Effective against malaria?

Protease inhibitors used to treat HIV-1 infection may also be effective for treatment or prevention of malaria, according to a study published in the December 15 issue of The Journal of Infectious Diseases, now available online. The study found protease inhibitors inhibited the growth of P. falciparum, the malaria parasite that causes most disease. These findings may also expose a previously unexplored vulnerability in the parasite that could lead to a new class of anti-malarial drug. While the effects of such drugs on co-infection need to be investigated, the study's findings may be especially significant in sub-Saharan Africa and other areas of the developing world where there are high rates of HIV and malaria co-infection.

Scientists from the Queensland Institute of Medical Research tested the effects of the protease inhibitors saquinavir, ritonavir, nelfinavir, amprenavir, and indinavir, as well as the non-nucleoside reverse transcriptase inhibitor nevirapine, on a drug-resistant line of P. falciparum. Saquinavir, ritonavir, and indinavir all inhibited parasite growth in vitro at levels routinely achieved in human patients, with saquinavir and ritonavir showing the most potent effect on the parasite. Saquinavir was most effective in the study and was equally effective on chloroquine-sensitive and -resistant parasite lines, while nelfinavir and amprenavir did not demonstrate anti-malarial activity. The research builds on a previous study that demonstrated antiretroviral agents can reduce the adhesion of P. falciparum-infected erythrocytes to endothelial surfaces.

The authors believe that the antiretroviral protease inhibitors attack the malaria parasite in ways that current antimalarial treatments do not. While the mode of antimalarial action of the drugs was not uncovered in the study, the authors hypothesize that the antiretrovirals inhibit an aspartyl protease, which helps the parasite digest hemoglobin and is located on the food vacuole of the
'"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
8-Nov-2004


Page: 1 2

Related medicine news :

1. HIV-1 spread through six transmission lines in the UK
2. Virco establishes comprehensive set of clinical cutoffs for the vircoTYPE HIV-1 resistance test
3. Supervised treatment interruptions fail to control HIV-1 viremia
4. Potential low-cost options for monitoring HIV-1-infected children in less-developed countries
5. Substantial survival increase after highly active antiretroviral therapy for HIV-1 infection
6. Antiretrovirals reduce mother-to-child HIV-1 transmission when started after childbirth
7. Pet scans could provide insight into HIV-1 progression
8. Further evidence for effectiveness of nevirapine in reducing mother-to-child HIV-1 transmission
9. Spermicide gel could increase risk of HIV-1 infection
10. Timely antiretroviral therapy essential for best prognosis in people with HIV-1 infection
11. Reduction in HIV-1 incidence among rural Ugandans gives hope to other African countries

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2020)... ... August 29, 2020 , ... When professor and author Randy Pausch was diagnosed ... people would. Rather than become melancholic, however, he put together a final lecture in ... Randy Pausch took a negative situation and turned it into something that inspired millions ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... ... assist system designed to help treat patients with respiratory conditions, including COVID-19, while ... of helium and oxygen, but it captures exhaled gas and scrubs it free ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... Group set out to continue helping the specialty-diet community connect with great, ... gluten-free products, get coupons, enter giveaways, chat with brands & watch over 50 ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... in advising Adventist Health on its investment in Synchronous Health, a tech-enabled behavioral ... that combines the strength of human empathy with artificial intelligence (AI) to increase ...
(Date:8/27/2020)... ... August 27, 2020 , ... Walk-in Dermatology’s SK-IN ... in its Greenvale, New York location. , Loren received her New York ... is certified in chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, facial lymphatic, and various ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... FLINT, Mich. (PRWEB) , ... August 27, 2020 , ... The flu season is right ... need to get well equipped with all the necessary measures before it begins to harbor ... is also increasing, and it is leaving a huge impact on our lives. Hence it ...
(Date:8/27/2020)... ... August 27, 2020 , ... Trella Health, the leading source ... of cloud CRM, marketing automation, and contact center solutions for senior living communities ... of Trella’s performance intelligence data and insights into Enquire’s CRM solution to serve ...
(Date:8/27/2020)... ... August 27, 2020 , ... The GHT Companies ... its fundraising initiative for Feeding San Diego with a press conference at ... Companies presents the final check of $5,000.00+ representing an overall donation result exceeding $30,000 ...
Breaking Medicine Technology:
Cached News: