HOME >> MEDICINE >> NEWS
HIV's deep pocket may reveal vulnerability

September 28, 1999 -- Using three-dimensional images of a key AIDS virus protein as their guide, a team of Howard Hughes Medical Institute (HHMI) investigators has found several chemical compounds capable of preventing the human immunodeficiency virus (HIV) from fusing with human cells. Without the ability to fuse to human cells, HIV cannot cause infection.

"Seeing the structure of this protein, gp41, suggested the whole experimental design," said Stephen Harrison, an HHMI investigator at Children's Hospital in Boston and Harvard University. In 1997, independent research teams led by HHMI investigators Don Wiley, also of Children's Hospital and Harvard University, and Peter Kim at the Whitehead Institute for Biomedical Research determined the three-dimensional structure of gp41 using x-ray crystallography.

HIV infects immune system cells that bear the CD4 molecule on their surface. A viral glycoprotein - a complex of protein and carbohydrate - called gp120 recognizes and binds to CD4, which triggers a change in the shape of the associated viral glycoprotein, gp41. These subsequent structural changes in gp41 must occur in order for HIV to enter a human cell.

In the October 1999 issue of Nature Structural Biology, Harrison, Wiley, fellow HHMI investigator Stuart Schreiber, and members of their laboratories at Harvard University, describe the creation of a library of more than 61,000 chemical compounds that could potentially fit into a deep pocket within the gp41 structure. Harrison and his colleagues screened each of the compounds and identified several that could prevent HIV infection by interfering with gp41.

Rather than develop drugs that interfere with viral replicatio
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-Sep-1999


Page: 1 2 3

Related medicine news :

1. U-M study: Physicians perceive health care cost savings line pockets of insurance companies
2. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
3. Brain imaging reveals secrets of love, fear and betrayal
4. New fingerprint visualization method uses X-rays to reveal missing clues
5. Emotional memory study reveals evidence for a self-reinforcing loop
6. Study reveals frequent non-guideline treatment of late-life depression
7. Americans support most uses of reproductive genetic testing, report on US attitudes reveals
8. Trial reveals safer and simpler approach to treating children with cystic fibrosis
9. Satellite data reveal immense pollution pool over Bihar, India
10. Study of CPR quality reveals frequent deviation from guidelines
11. New study reveals treatment for silent killer using diet, not drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... Fla. (PRWEB) , ... August 14, 2018 , ... Ross ... next generation of freezing fat, at Clevens Face and Body Specialists. Dr. Clevens is ... to patients at his Melbourne and Merritt Island offices. Along with his associate, Amy ...
(Date:8/11/2018)... ... August 10, 2018 , ... ... providing innovative procedures to metro Atlanta. Drs. Brent Sharpe and Froylan Gonzalez recently ... Medical Center in Braselton. , On June 27, the physicians combined their expertise ...
(Date:8/9/2018)... COSTA MESA, Calif. (PRWEB) , ... August 09, ... ... treatment, officially announces LegitScript certification. LegitScript is a new verification process that substance ... Longridge said, “Being LegitScript certified means we can reach more people to help.” ...
(Date:8/7/2018)... ... August 07, 2018 , ... Josh Sprague, Founder and CEO of athletic goods ... the upcoming Leadville 100 MTB. , Accompanied by colleague Marvin Sandoval and equipped ... called “one of the most iconic mountain bike race courses in the world.” ...
(Date:8/3/2018)... , ... August 03, 2018 , ... ... UK since 2001. Gerry Newlove first started the Firstaid4sport business in the 1990's ... and Firstaid4Sport remains one of the leading providers in the UK of sports ...
Breaking Medicine News(10 mins):
(Date:8/3/2018)... , ... August 03, 2018 , ... ... the top 10 ACT patents list of the 5,000-strong association of app companies ... patent for “Mobile Self-Management Compliance and Notification Method System and Computer Program Product” ...
(Date:8/2/2018)... ... August 02, 2018 , ... Periodontist, ... for custom crown lengthening treatment at his Eden Prairie, MN practice. ... an unsteady self-conscious. Using decades of experience, Dr. Sanchez is excited to welcome ...
(Date:8/2/2018)... PASS, Ore. (PRWEB) , ... August 02, 2018 ... ... Montero Medical Missions humanitarian efforts, is an inspiring, international leader of sustainable advocacy. ... Water Life Science®/Nature’s Pharma®, The Power of Water® & Your Health sponsored by ...
Breaking Medicine Technology:
Cached News: