HOME >> MEDICINE >> NEWS
HIV's deep pocket may reveal vulnerability

September 28, 1999 -- Using three-dimensional images of a key AIDS virus protein as their guide, a team of Howard Hughes Medical Institute (HHMI) investigators has found several chemical compounds capable of preventing the human immunodeficiency virus (HIV) from fusing with human cells. Without the ability to fuse to human cells, HIV cannot cause infection.

"Seeing the structure of this protein, gp41, suggested the whole experimental design," said Stephen Harrison, an HHMI investigator at Children's Hospital in Boston and Harvard University. In 1997, independent research teams led by HHMI investigators Don Wiley, also of Children's Hospital and Harvard University, and Peter Kim at the Whitehead Institute for Biomedical Research determined the three-dimensional structure of gp41 using x-ray crystallography.

HIV infects immune system cells that bear the CD4 molecule on their surface. A viral glycoprotein - a complex of protein and carbohydrate - called gp120 recognizes and binds to CD4, which triggers a change in the shape of the associated viral glycoprotein, gp41. These subsequent structural changes in gp41 must occur in order for HIV to enter a human cell.

In the October 1999 issue of Nature Structural Biology, Harrison, Wiley, fellow HHMI investigator Stuart Schreiber, and members of their laboratories at Harvard University, describe the creation of a library of more than 61,000 chemical compounds that could potentially fit into a deep pocket within the gp41 structure. Harrison and his colleagues screened each of the compounds and identified several that could prevent HIV infection by interfering with gp41.

Rather than develop drugs that interfere with viral replicatio
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-Sep-1999


Page: 1 2 3

Related medicine news :

1. U-M study: Physicians perceive health care cost savings line pockets of insurance companies
2. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
3. Brain imaging reveals secrets of love, fear and betrayal
4. New fingerprint visualization method uses X-rays to reveal missing clues
5. Emotional memory study reveals evidence for a self-reinforcing loop
6. Study reveals frequent non-guideline treatment of late-life depression
7. Americans support most uses of reproductive genetic testing, report on US attitudes reveals
8. Trial reveals safer and simpler approach to treating children with cystic fibrosis
9. Satellite data reveal immense pollution pool over Bihar, India
10. Study of CPR quality reveals frequent deviation from guidelines
11. New study reveals treatment for silent killer using diet, not drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... ... 2019 , ... Mount Sinai Health System is hosting a ... Nations Staff Recreation Council in support of the Helen Sawaya Fund, a philanthropic ... art, massage, and pet therapies to increase the comfort and emotional and mental ...
(Date:1/10/2019)... ... ... The Karis Group, an Austin, Texas based company, announced today that it has ... Mr. Jiwa succeeds the past Chief Executive Officer, Mike Martin, who retired from ... as part of an orderly succession plan and transition of leadership at the 22-year ...
(Date:1/8/2019)... ... ... West 10th Dental in New York, NY is pleased to announce the launch ... founder of West 10th Dental, "We want our patients to know that we are, ... up with the latest in technology as dentistry changes, and by making ourselves always ...
(Date:1/8/2019)... (PRWEB) , ... January 08, 2019 , ... In Partnership ... provide free dental services for low-income, underinsured individuals in Las Vegas, NV on February ... x-rays, fillings, cleanings and extractions. For more information, please visit the Smiles for Everyone ...
(Date:1/7/2019)... , ... January 07, 2019 , ... ... Course is now a candidate for accreditation from the American Society of ... nationwide. The organization’s 45,000 members include pharmacists, student pharmacists and pharmacy technicians. , ...
Breaking Medicine News(10 mins):
(Date:1/11/2019)... ... ... According to research, acupuncture can quickly and effectively treat sinusitis, allergy, and asthma ... the respiratory treatment they need at its Houston clinic. , “We don’t just treat ... Acupuncture and Chinese Medicine can treat a wide range of conditions,” said Sylvia He, ...
(Date:1/10/2019)... (PRWEB) , ... January 10, 2019 , ... ... to introduce the new A-Series Advantage Anesthesia Delivery platform, providing a modular, state-of-the-art ... A7 Advantage systems, enabling Mindray to continue its unwavering commitment to perioperative care. ...
(Date:1/8/2019)... ... January 08, 2019 , ... University Hospitals ... UroLift® Center of Excellence. The designation recognizes that Dr. Jaeger has achieved a ... commitment to exemplary care for men suffering from symptoms associated with benign prostatic ...
Breaking Medicine Technology:
Cached News: