Heart Valve Abnormalities Examined In Relation To Duration Of Diet Drug Use

NEW ORLEANS -- In the largest study of its kind, Duke University Medical Center researchers found that the longer a person used a popular duet of diet drugs known as "fen/phen," the greater the likelihood they had a heart valve abnormality.

Duke researchers said in a report prepared for the annual meeting of the American College of Cardiology that they found evidence on a cardiac diagnostic test of "mild or greater aortic regurgitation" in 8.8 percent of 1,163 patients who used fen/phen for three months or more. In comparison, they detected the same problem in 3.6 percent of a control group of 672 overweight people who had not taken the drug.

In a study funded by Wyeth-Ayerst Laboratories, makers of the "fen" in fen/phen, the research team determined that the prevalence of this valve problem was related to the duration of time the drug was used. Among those who used the diet drug combo for less than six months, there was no increase in mild or greater aortic regurgitation, but "the longer people in this study took the drugs, the greater the likelihood that they showed some abnormality on an echocardiogram," said Duke cardiologist Dr. Thomas Ryan.

He added that most of the cases of aortic regurgitation noted by the research team were graded as "trace or mild. In our clinical experience, most patients with mild aortic regurgitation have few if any symptoms because the heart can compensate for this leakage," Ryan said.

Aortic regurgitation occurs when blood leaks from the aorta -- the large artery that distributes blood to the body -- back through the aortic valve into the left ventricle, the heart's main pumping chamber. Ryan said that while the likelihood of developing the leaking valve increased the longer a person took fen/phen, it didn't mean the problem became more and more severe over time.

Ryan also said that the Duke cardiology team noted a statistically significant increase i

Contact: Renee Twombly
Renee Twombly
Duke University Medical Center

Page: 1 2 3

Related medicine news :

1. The European Society of Cardiology launches Women at Heart
2. Heart surgeons publish death rates
3. Heart attack treatment gap may be closing for women
4. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
5. Brenner Childrens Hospital named to NIH Pediatric Heart Network
6. Heart patients treated by non-cardiologists less likely to receive medications
7. Heart failure patients treated for diabetes with insulin have increase in mortality
8. New research results: Heart jacket shown to be effective
9. Heart surgery patients receive less aggressive discharge care
10. Heart attack, stroke risk overlooked in diabetics
11. Heart arrhythmias easily treated, yet few know risks

Post Your Comments:

(Date:2/21/2020)... ... 21, 2020 , ... Isagenix International , a global ... and final round of Canada finalists for its annual total-body transformation program, the ... Ontario; Taiya Farrell of Winnipeg, Manitoba; Véronique Collin of Orleans, Ontario; and James ...
(Date:2/20/2020)... (PRWEB) , ... February 20, 2020 , ... ... agents, has a new release with next generation API integration functionality which ... by VisitorsCoverage Inc. in 2017, TMQuotes was the first white label ...
(Date:2/19/2020)... ... , ... Actor, director, and producer, Laurence Fishburne is no ... abilities demonstrated in blockbuster hits like the “John Wick” series, Fishburne also makes ... “Behind The Scenes” features a broad array of topics. A new episode will ...
(Date:2/19/2020)... , ... February 19, 2020 , ... ... implant manufacturer, will highlight its growing product portfolio for lower extremities at the ... the Henry B. Gonzalez Convention Center. The Trigon® Ti Stand-Alone Osteotomy Wedge Fixation ...
(Date:2/16/2020)... ... 16, 2020 , ... Canadian digital healthcare portal Ask The Doctor ... concerned about the Coronavirus. , "It is our duty and it is our responsibility ... virus" said Prakash Chand, CEO of Ask The Doctor. , Doctors and nurses around ...
Breaking Medicine News(10 mins):
(Date:2/19/2020)... ... ... Aspire Regenerative, a leader in offering therapies that restore healthy tissues in the ... on March 1, 2020. It will take place from 10:30 a.m. to 1:30 p.m. ... event, physicians and pharmacists will lead an informative and insightful discussion on weight loss. ...
(Date:2/19/2020)... ... February 19, 2020 , ... Drs. Mario Canal and Ben Calem ... 2020 at The Mansion in Voorhees. The course features guest speaker, Dr. Amanda Seay, ... Dental implants, including All-on-4® full mouth dental implants, are a major ...
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... The Team ... equal access to medicine for everyone affected by diabetes, announced a partnership with VeloCity, ... , The third annual VeloCity event takes place on May 2nd and begins ...
Breaking Medicine Technology:
Cached News: