HOME >> MEDICINE >> NEWS
Heart-stopping drugs

A NEW way of stopping the heart during bypass operations could reduce damage to the heart and improve patients' chances of a full recovery.

More than a million people a year have open-heart surgery to unblockor bypass clogged arteries, or repair damaged valves. The heart is usually stopped for about one hour while they are under the knife because it is impossible to operate on a moving target. But the standard method of achieving this- flooding the heart with potassium ions- can cause permanent damage.

Now Geoffrey Dobson and Michael Jones of James Cook University in Townsville, Australia, have developed an alternative. It has only been tested on animals so far, but experts say the results, due to appear in the Journal of Thoracic and Cardiovascular Surgery, look promising. "By keeping potassium levels normal they are preventing injuries to the muscle cells and to the vessels that carry blood to the heart," says Peter Macdonald, a cardiologist at St Vincent's Hospital in Sydney.

In resting muscle cells, the distribution of ions across the cell membrane generates an electric potential. The waves of electrical activity that sweep across the heart, telling muscle cells to contract, are generated when channels in the membrane open, allowing ions to flow across the membrane and depolarise the cells. Flooding the heart with potassium ions freezes its cells in this depolarised state.

Dobson and Jones instead freeze the heart in the resting state using two drugs: adenosine, which opens some of the channels that transport potassium ions in and out of the cell, and lignocaine (known as lidocainein the US), which blocks sodium ion channels.

"There are two ways to stop a heart cell. Let it run out of gas- that's the potassium infusion-or to not even turn it on. That's what Dobson has done," says Jakob Vinten-Johansen, a cardiovascular physiologist at Emory University in Atlanta, Georgia, who now collaborates with Dobson.

Whe
'"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-207-331-2751
New Scientist
17-Sep-2003


Page: 1 2 3

Related medicine news :

1. UW research shows risk factors for relapse among health care professionals who abuse drugs
2. New studies show mixed results on epilepsy drugs and birth defects
3. Newly discovered pathway might help in design of cancer drugs
4. Study examines consequences of Thailands war on drugs
5. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
6. Three anti-platelet drugs used in combination are safe
7. HIV patients may be at risk of heart problems when taking protease inhibitor drugs
8. Clot-busting drugs may help detect potentially deadly leg clots
9. Herb used to treat diabetes works like modern-day prescription drugs, study suggests
10. Penn study shows how next-generation diabetic drugs could work more selectively
11. Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Heart stopping drugs

(Date:2/27/2015)... San Diego, CA (PRWEB) February 27, 2015 ... Industries’ Vortex-Genie® 2 , price is only valid ... caters to lab technicians looking for a vortex mixer ... , Scientific Industries was founded in 1954 and is ... Vortex-Genie® laboratory mixers & shakers, as well as other ...
(Date:2/27/2015)... Evans, GA (PRWEB) February 27, 2015 In honor ... Center for Primary Care (CPC) South office, is offering tips on ... leading cause of death, but that doesn't mean people have to ... to change some risk factors — such as family history, sex ... to take. , Dr. Scott has six helpful tips to ...
(Date:2/27/2015)... NY (PRWEB) February 27, 2015 In ... to the community by providing free dental care from ... has partnered with Dentistry from the Heart, and ... 11, 2015. The first 50 patients who are in ... they can’t afford, will have access to high­quality service ...
(Date:2/27/2015)... Undocumented farmworkers are half as ... Medicaid, the federal health insurance program available to ... study from UC Davis Health System. The research ... use of Medicaid, which provides coverage for prenatal, ... was having children. , “Undocumented agricultural workers ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 The V ... cancer research funding organizations, is excited to announce numerous ... to participate and many long-standing partnerships highlight The V ... focus on expanding ways for all to get involved. ... to cutting-edge cancer research, The V Foundation has funded ...
Breaking Medicine News(10 mins):Health News:Pipette.com Announces Limited Time Offer of 24% Off List Price on the Vortex-Genie 2 2Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4Health News:Dr. Umanoff Unites with Dentistry from the Heart to Provide Community with Charitable Dental Care 2Health News:Dr. Umanoff Unites with Dentistry from the Heart to Provide Community with Charitable Dental Care 3Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 2Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 3Health News:The V Foundation Reinforces its Fight Against Cancer with New and Extended Partnerships 2Health News:The V Foundation Reinforces its Fight Against Cancer with New and Extended Partnerships 3
(Date:2/26/2015)... -- IRIDEX Corporation (NASDAQ: IRIX ) today announced that ... financial results after the market closes on Thursday, March ... will host a conference call with the investment community at ... 5, 2015 to discuss the results of the quarter ... the live conference call via telephone by dialing (877) 407-0784 ...
(Date:2/26/2015)... N.Y. , Feb. 26, 2015 Every ... more research to fight heart disease.  Nevertheless, year after ... on ElectroCardioGrams (EKG) as the first test to determine ... they have chest pain or not, even though that ... occurs despite the fact that doctors know, (while most ...
(Date:2/26/2015)... MILFORD, Mass. , Feb. 26, 2015 /PRNewswire/ ... developing novel therapeutics for the treatment of Hepatitis ... announced the closing of a $22 million financing. ... of SB 9200, a novel, broad spectrum antiviral ... molecule nucleic acid hybrid (SMNH) chemistry platform, into ...
Breaking Medicine Technology:IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2National Heart Health Month In February 2Spring Bank Pharmaceuticals Completes $22 Million Financing 2
Cached News: