HOME >> MEDICINE >> NEWS
Heart-stopping drugs

A NEW way of stopping the heart during bypass operations could reduce damage to the heart and improve patients' chances of a full recovery.

More than a million people a year have open-heart surgery to unblockor bypass clogged arteries, or repair damaged valves. The heart is usually stopped for about one hour while they are under the knife because it is impossible to operate on a moving target. But the standard method of achieving this- flooding the heart with potassium ions- can cause permanent damage.

Now Geoffrey Dobson and Michael Jones of James Cook University in Townsville, Australia, have developed an alternative. It has only been tested on animals so far, but experts say the results, due to appear in the Journal of Thoracic and Cardiovascular Surgery, look promising. "By keeping potassium levels normal they are preventing injuries to the muscle cells and to the vessels that carry blood to the heart," says Peter Macdonald, a cardiologist at St Vincent's Hospital in Sydney.

In resting muscle cells, the distribution of ions across the cell membrane generates an electric potential. The waves of electrical activity that sweep across the heart, telling muscle cells to contract, are generated when channels in the membrane open, allowing ions to flow across the membrane and depolarise the cells. Flooding the heart with potassium ions freezes its cells in this depolarised state.

Dobson and Jones instead freeze the heart in the resting state using two drugs: adenosine, which opens some of the channels that transport potassium ions in and out of the cell, and lignocaine (known as lidocainein the US), which blocks sodium ion channels.

"There are two ways to stop a heart cell. Let it run out of gas- that's the potassium infusion-or to not even turn it on. That's what Dobson has done," says Jakob Vinten-Johansen, a cardiovascular physiologist at Emory University in Atlanta, Georgia, who now collaborates with Dobson.

Whe
'"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-207-331-2751
New Scientist
17-Sep-2003


Page: 1 2 3

Related medicine news :

1. UW research shows risk factors for relapse among health care professionals who abuse drugs
2. New studies show mixed results on epilepsy drugs and birth defects
3. Newly discovered pathway might help in design of cancer drugs
4. Study examines consequences of Thailands war on drugs
5. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
6. Three anti-platelet drugs used in combination are safe
7. HIV patients may be at risk of heart problems when taking protease inhibitor drugs
8. Clot-busting drugs may help detect potentially deadly leg clots
9. Herb used to treat diabetes works like modern-day prescription drugs, study suggests
10. Penn study shows how next-generation diabetic drugs could work more selectively
11. Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Heart stopping drugs

(Date:8/30/2014)... The KSF (Kung Fu Sanshou Federation) ... on November 8th, 2014 at the Mobile Civic Center ... introduced many notorious and notable fighters for some top ... UFC. , Among these KSF along with the ... armed with the virtues of true indomitable Shaolin spirit, ...
(Date:8/30/2014)... Saturday 30 August 2014: The first expert ... novel document compiles current evidence on the diagnosis ... by international experts from three continents. , The ... today on-line in EP Europace (1). ... Rhythm Association (EHRA) of the European Society of ...
(Date:8/30/2014)... Saturday 30 August 2014: The therapeutic benefit of ... in the 2014 ESC/EACTS revascularisation guidelines presented at ... Stephan Windecker (Switzerland) of the European Society of ... the European Association for Cardio-Thoracic Surgery (EACTS). The ... European Heart Journal (1), on the ESC ...
(Date:8/29/2014)... San Diego (PRWEB) August 30, 2014 ... and their loved ones and caretakers. Author Eddie M. Leung ... with cholangiocarcinoma or bile duct cancer, a very ... “The Year That Changed My Life” (published by Xlibris), he ... but more importantly, he imparts a survivor’s testimony that this ...
(Date:8/29/2014)... 2014 According to the latest review published ... lose weight quickly, safely and naturally. The new method promises ... amazingly fast, too. , Daily Gossip writes in its ... only teach patients how to eliminate the extra pounds, it ... when it comes to body modeling. , The method ...
Breaking Medicine News(10 mins):Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 3Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 4Health News:First expert consensus on ventricular arrhythmias published 2Health News:First expert consensus on ventricular arrhythmias published 3Health News:ESC/EACTS revascularization guidelines stress benefit of revascularization in stable CAD 2Health News:ESC/EACTS revascularization guidelines stress benefit of revascularization in stable CAD 3Health News:Eddie M. Leung Shares His Testimony As a Survivor of Cancer 2Health News:Eddie M. Leung Shares His Testimony As a Survivor of Cancer 3Health News:Flat Belly Forever Review Exposes the Way to Eliminate Body Fat Easily 2
(Date:8/29/2014)... , Aug. 29, 2014  Abaxis, Inc. (NasdaqGS: ... point-of-care blood instrumentation and consumables to the medical, research ... , Chairman and Chief Executive Officer, will present at ... Conference 2014 on Tuesday, September 9, 2014 at 12:30 ... Omni Berkshire Place Hotel in New York ...
(Date:8/29/2014)... and MENLO PARK, Calif. , Aug. ... (OTCQB: DMPI) ("DelMar" "the Company") today announced the ... The Company recently changed its fiscal year end to ... list its common stock on a national securities exchange ... statements as filed with the United States Securities Exchange ...
(Date:8/29/2014)... Research and Markets  has announced the addition of ... 2014-2018" report to their offering. ... connect, support, or surround bones. There are several types ... fascia, and other fibrous tissues. Repetitive use, accidents, injuries, ... in wear and tear in these tissues. Orthopedic soft ...
Breaking Medicine Technology:Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 3
Cached News: