HOME >> MEDICINE >> NEWS
Hepatotoxicity and statins

Statins appear to be safe for people with fatty liver disease who could benefit from their cholesterol-lowering capabilities, concludes a review paper published in the April 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., the journal is available online via Wiley InterScience at www.interscience.wiley.com/journal/hepatology.

Statins are a class of drugs that lower cholesterol levels by inhibiting the liver's production of cholesterol. They have been shown to decrease the risk of artherosclerosis and related diseases. In the United States, doctors write millions of prescriptions for statins each year. However, commonly, patients on statins have elevations of liver enzymes. Current statin product packaging recommends monitoring patients' liver values over the course of their usage. This recommendation may concern physicians whose patients also have known liver conditions, including elevated, though asymptomatic, liver enzymes.

Naga Chalasani, M.D., of Indiana University School of Medicine, thoroughly examined the literature related to statin hepatotoxicity to better understand statins' effects on patients. Statins, especially in increasing doses, have been associated with asymptomatic elevation of aminotransferases, though this occurs in fewer than three percent of statin users. Notably, this outcome has also occurred with similar frequency in placebo-treated patients in clinical trials. This "raises the possibility that hyperlipidemic patients may have spontaneous fluctuations in transaminases whether or not they receive statins," Chalasani suggests. Still, there have been rare reports of significant liver injury associated with statins.

Statins are not recommended for patients with active liver disease, though the recommendations for those with nonalcoholic fatty liver d
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
25-Mar-2005


Page: 1 2 3

Related medicine news :

1. Jefferson scientists help explain statins effects in Alzheimers disease
2. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease
3. CRESTOR leads in 1st international prospective study of statins in the metabolic syndrome
4. OTC statins: A bad decision for public health
5. ESC highlights need for screening and global risk management as statins move over the counter in UK
6. ACP guidelines: Many diabetics should be taking statins
7. Patients should be allowed to pay for statins
8. Use of statins may prevent breast cancer, say University of Pittsburgh researchers
9. Genetic bar codes predict effect of statins
10. Stopping statins may cause rebound that triples risk of death

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2017)... ... May 28, 2017 , ... HYPERAMS, LLC announced ... and uniform distributor based in Lima, Ohio. The sale began this week and the ... units of medical garments, scrubs, uniforms, and medical accessories, including blood pressure cuffs, stethoscopes, ...
(Date:5/28/2017)... ... May 28, 2017 , ... Florida Pain Relief ... that Jorge Fernandez-Silva, M.D., has joined its new Melbourne pain clinic. , ... on minimally invasive techniques to treat and manage many types of pain. ...
(Date:5/28/2017)... Haven, FL (PRWEB) , ... May 28, 2017 ... ... Partners of America (PPOA), is proud to announce that Sheldon K. Cho, MD, ... comprehensive interventional pain management, a specialty that concentrates on minimally invasive techniques to ...
(Date:5/28/2017)... ... May 28, 2017 , ... Viewers likely know Rob Lowe from such ... also noted for his work on NBC’s The West Wing and Parks and Recreation. ... new series “Informed,” which puts the spotlight on important modern-day issues that face today’s ...
(Date:5/27/2017)... , ... May 26, 2017 , ... A May 8 ... visit a doctor for colds or respiratory issues that are not responsive to antibiotics ... pressure on doctors may be largely responsible for the problem both in Canada and ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... 22, 2017  As the specialty pharmacy industry ... to make the revolutionary shift from volume-based to ... ensuring positive patient outcomes and shaping the future ... focus away from clinical trials and toward data ... specialty drug therapy utilization in precise patient populations. ...
(Date:5/12/2017)... Canada joint tech company Laughing Face has developed ... and features a powerful disinfection process. The company has ... and sanitizes women,s panties or babies, cloth diapers in 25 minutes. ... Laughing ... external water inlet. ...
(Date:5/10/2017)... , May 10, 2017 Radiology has ... unfortunately its costs have also spiraled to the number ... sent to radiology than ever before as the most ... For a patient with lower back pain an MRI ... anatomical reason for pain, resulting in entirely different treatment ...
Breaking Medicine Technology:
Cached News: