HOME >> MEDICINE >> NEWS
Hepatotoxicity and statins

Statins appear to be safe for people with fatty liver disease who could benefit from their cholesterol-lowering capabilities, concludes a review paper published in the April 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., the journal is available online via Wiley InterScience at www.interscience.wiley.com/journal/hepatology.

Statins are a class of drugs that lower cholesterol levels by inhibiting the liver's production of cholesterol. They have been shown to decrease the risk of artherosclerosis and related diseases. In the United States, doctors write millions of prescriptions for statins each year. However, commonly, patients on statins have elevations of liver enzymes. Current statin product packaging recommends monitoring patients' liver values over the course of their usage. This recommendation may concern physicians whose patients also have known liver conditions, including elevated, though asymptomatic, liver enzymes.

Naga Chalasani, M.D., of Indiana University School of Medicine, thoroughly examined the literature related to statin hepatotoxicity to better understand statins' effects on patients. Statins, especially in increasing doses, have been associated with asymptomatic elevation of aminotransferases, though this occurs in fewer than three percent of statin users. Notably, this outcome has also occurred with similar frequency in placebo-treated patients in clinical trials. This "raises the possibility that hyperlipidemic patients may have spontaneous fluctuations in transaminases whether or not they receive statins," Chalasani suggests. Still, there have been rare reports of significant liver injury associated with statins.

Statins are not recommended for patients with active liver disease, though the recommendations for those with nonalcoholic fatty liver d
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
25-Mar-2005


Page: 1 2 3

Related medicine news :

1. Jefferson scientists help explain statins effects in Alzheimers disease
2. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease
3. CRESTOR leads in 1st international prospective study of statins in the metabolic syndrome
4. OTC statins: A bad decision for public health
5. ESC highlights need for screening and global risk management as statins move over the counter in UK
6. ACP guidelines: Many diabetics should be taking statins
7. Patients should be allowed to pay for statins
8. Use of statins may prevent breast cancer, say University of Pittsburgh researchers
9. Genetic bar codes predict effect of statins
10. Stopping statins may cause rebound that triples risk of death

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hepatotoxicity and statins

(Date:3/4/2015)... 2015 TROY Healthcare Solutions will be ... the ultimate level of security for prescriptions, in Houston, ... Plaza Medical Center located at 6633 Travis Street from ... 7 AM, TROY Healthcare Solutions will host a continental ... offer brief presentations each hour to introduce attendees to ...
(Date:3/4/2015)... York, NY (PRWEB) March 04, 2015 ... creative, breakthrough marketing campaign called 'We Love Smokers' from ... cravings for tobacco. , "It’s important to establish ... be true to it. Our idea, 'We Love Smokers' ... leadership point of view. We created a bold tone ...
(Date:3/4/2015)... 2015 Starting February 2015, Dr. Joseph ... procedures at their new location in Surrey. , In ... and Dr. Gabriel Chu also provide comprehensive ophthalmology services, ... named Fraser Valley Cataract and Laser (FVCL). This state ... College of Physicians and Surgeons of British Columbia. Fraser ...
(Date:3/4/2015)... 2015 " Optrix by Body Glove ... monthly Tech Report, which takes a look at the ... consumers. Scott Steinberg, a special reporter for NewsWatch and ... with viewers how they have an ultra-rugged, waterproof case ... is a major player at the Consumer Electronics Show ...
(Date:3/4/2015)... 2015 The New Mel Brooks Musical ... will be performed by the award-winning Drama Department of ... March 6-22, 2015, on Fridays, Saturdays and Sundays. Performances ... School (27118 Silver Spur Road, Rolling Hills Estates, ... program or may be purchased on-line at https://sites.google.com/site/penhidrama ...
Breaking Medicine News(10 mins):Health News:TROY Healthcare to Offer Prescription Solutions that can save a Hospital $100,000 2Health News:TROY Healthcare to Offer Prescription Solutions that can save a Hospital $100,000 3Health News:The Brand Behind The Bold and Provocative Ad Campaign 'We Love Smokers' 2Health News:The Brand Behind The Bold and Provocative Ad Campaign 'We Love Smokers' 3Health News:King LASIK relocates to Surrey, British Columbia 2Health News:A Waterproof Phone Case with an Interchangeable Lens System was Featured on NewsWatch Television on January 30, 2015 2Health News:The New Mel Brooks Musical Young Frankenstein Performance March 6-March 22, 2015, by the Award Winning Drama Department at Peninsula High School, Rolling Hills 2
(Date:3/4/2015)... 4, 2015  Bayer HealthCare today announced that ... accepted the company,s Biologics License Application (BLA) for ... is seeking FDA approval of the investigational compound, ... hemophilia A in children and adults. ... therapies to hemophilia A patients who need them," ...
(Date:3/4/2015)... Colo. , March 4, 2015  Heska Corporation ... What:Heska Corporation Invites You to Join Its Fourth Quarter ... WebWhen:Thursday, March 5, 2015 @ 9:00 a.m. (MST) / ... and Year End 2014 Earnings Call link on the ... Simply log on to the web at the address ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4f69k2/negative_pressure ) ... Pressure Wound Therapy Market (Conventional and Single Use ... Growth, Trends and Forecast 2014 - 2020" ... The global negative pressure wound therapy market is ... product types the NPWT market is segmented into ...
Breaking Medicine Technology:FDA Accepts Bayer's Biologics License Application for Investigational Treatment Option in Hemophilia A 2FDA Accepts Bayer's Biologics License Application for Investigational Treatment Option in Hemophilia A 3Webcast Alert: Heska Announces Fourth Quarter and Year End 2014 Earnings Conference Call Webcast 2Global Negative Pressure Wound Therapy (Conventional and Single Use NPWT Systems) Market Report 2014-2020 2
Cached News: