HOME >> MEDICINE >> NEWS
Hepatotoxicity and statins

Statins appear to be safe for people with fatty liver disease who could benefit from their cholesterol-lowering capabilities, concludes a review paper published in the April 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., the journal is available online via Wiley InterScience at www.interscience.wiley.com/journal/hepatology.

Statins are a class of drugs that lower cholesterol levels by inhibiting the liver's production of cholesterol. They have been shown to decrease the risk of artherosclerosis and related diseases. In the United States, doctors write millions of prescriptions for statins each year. However, commonly, patients on statins have elevations of liver enzymes. Current statin product packaging recommends monitoring patients' liver values over the course of their usage. This recommendation may concern physicians whose patients also have known liver conditions, including elevated, though asymptomatic, liver enzymes.

Naga Chalasani, M.D., of Indiana University School of Medicine, thoroughly examined the literature related to statin hepatotoxicity to better understand statins' effects on patients. Statins, especially in increasing doses, have been associated with asymptomatic elevation of aminotransferases, though this occurs in fewer than three percent of statin users. Notably, this outcome has also occurred with similar frequency in placebo-treated patients in clinical trials. This "raises the possibility that hyperlipidemic patients may have spontaneous fluctuations in transaminases whether or not they receive statins," Chalasani suggests. Still, there have been rare reports of significant liver injury associated with statins.

Statins are not recommended for patients with active liver disease, though the recommendations for those with nonalcoholic fatty liver d
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
25-Mar-2005


Page: 1 2 3

Related medicine news :

1. Jefferson scientists help explain statins effects in Alzheimers disease
2. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease
3. CRESTOR leads in 1st international prospective study of statins in the metabolic syndrome
4. OTC statins: A bad decision for public health
5. ESC highlights need for screening and global risk management as statins move over the counter in UK
6. ACP guidelines: Many diabetics should be taking statins
7. Patients should be allowed to pay for statins
8. Use of statins may prevent breast cancer, say University of Pittsburgh researchers
9. Genetic bar codes predict effect of statins
10. Stopping statins may cause rebound that triples risk of death

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2016)... Grants Pass, OR (PRWEB) , ... May 06, 2016 , ... ... the eyes. In other seasons, when the weather is too cold, dry or hot, ... weather, the eyes can actually absorb moisture from the surrounding air. There’s only one ...
(Date:5/6/2016)... ... ... From the Speaker Podium to the Exhibit Floor at Booth#514, Worldwide Leading Contact Center ... at SpeechTek 2016 Event, taking place May 23-25 at the Omni Shoreham in Washington ... “5 Customer Engagement Strategies to improve Customer Satisfaction in your Contact Center” on May ...
(Date:5/6/2016)... , ... May 06, 2016 , ... ... to Sleepopolis.com . , Since launching in September, 2014 Sleepopolis has resided ... testing areas, which now include pillows, sheets, mattress toppers, bed frames, and more. ...
(Date:5/6/2016)... NJ (PRWEB) , ... May 06, 2016 , ... ... December 2013 arrival of Sovaldi, which made headlines mostly for its cost despite ... then, policy and moral questions surrounding the drug—part of a class called direct-acting ...
(Date:5/6/2016)... ... May 06, 2016 , ... Kenneth Cochran, ... of Cardiovascular Institute of the South announced today that Dr. Robert Menuet, Interventional ... of an Intravascular Ultrasound Guided Coronary Atherectomy. , This procedure involves ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Actinic Keratosis Market and ... their offering.       (Logo: ... Market and Competitive Landscape Highlights 2016, provides ... Actinic Keratosis epidemiology, Actinic Keratosis market valuations ...
(Date:5/3/2016)... PUNE, India , May 4, 2016 /PRNewswire/ ... report spreads across 154 pages, profiling 09 key ... It is a professional and in-depth study on ... providing a basic overview of the industry including ... Insulin Needles market analysis is provided for the ...
(Date:5/3/2016)... , May 4, 2016 Research ... "Global Cancer Stem Cell Therapy Market Outlook 2020" ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,Recombinant technology has improved significantly ... expected to be developed in coming years. Many cancer ... Cancer stem cell therapies are also expected to be ...
Breaking Medicine Technology:
Cached News: