HOME >> MEDICINE >> NEWS
High blood pressure drug promotes new blood vessel growth in lab animals, providing potential 'angiogenesis' treatment

DALLAS, June 15 -- A drug used to lower high blood pressure can stimulate the growth of new blood vessels in laboratory animals.

The findings, reported in today's Circulation: Journal of the American Heart Association, suggest that the drug, quinaprilat, may prove useful for treating people with severe chest pain (angina) and others at high risk of suffering a heart attack, says the study's senior author Jeffrey M. Isner, M.D., professor of medicine and pathology at Tufts University School of Medicine in Boston.

Quinaprilat, marketed as Acupril, is one of several drugs known as angiotensin-conversion-enzyme (ACE) inhibitors, which are used primarily to treat high blood pressure and congestive heart failure. These drugs block the activation of angiotensin, which in its active form causes blood vessels to constrict. When blood vessels are constricted, the heart has to pump harder to force blood through the body.

"The study demonstrates an unexpected function of a class of drugs that is commercially available and already has been shown to be safe to use. Quinaprilat deserves to be investigated for its potential use for promoting blood vessel growth," says Isner.

The study findings may explain previous reports that ACE inhibitors can benefit individuals who have reduced blood flow to their hearts that can cause chest pain, or angina, says Isner.

"One reason for the interest in this approach is that ACE inhibitors are drugs that can be taken orally," he adds. "If they work out for this kind of application, they would be easy for patients to use and potentially would be among the simplest strategies one could devise for promoting new blood vessel formation."

The growth of new blood vessels is called angiogenesis. In recent years, scientists have focused considerable attention on drugs and natural molecules in the body that promote or inhibit angiogenesis. Pro-angiogenesis treatments also could help people when leg blood vessels are ob
'"/>

Contact: Karen Hunter
khunter@heart.org
214-706-1330
American Heart Association
14-Jun-1999


Page: 1 2 3 4

Related medicine news :

1. A marker for new blood vessel formation in tumors
2. Acupuncture found to lower elevations in blood pressure
3. Diagnostic test for range of blood disorders on the horizon
4. Research suggests possible blood test for multiple sclerosis
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. Simple blood test may help to predict cardiovascular risk in older women
7. Drug that hinders blood vessel growth under study in ovarian cancer
8. Laughter helps blood vessels function better
9. St. Johns wort amplifies effect of blood thinner Plavix
10. Latest findings on genetic blood disorder Cooleys Anemia
11. Can routine commercial cord blood banking be scientifically and ethically justified?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ... June 23, 2017 , ... Military Connection friend and veteran ... the JFK Virgin Atlantic lounge. , Bensko is no stranger to the plight ... Bensko dedicated her life to supporting our wounded veterans. A world-class photographer, her riveting ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has recently highlighted ... has come up with a proprietary technique that he calls the AuraLyft ... dropped. For all ages, patients can expect to look refreshed, rejuvenated, and revitalized. ...
(Date:6/23/2017)... ... 23, 2017 , ... 21 Middle East and South Asia Leaders Selected as ... government, business and civil society in 11 countries across the Middle East and South ... a transformative exchange of knowledge and ideas with the leading minds in their fields. ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance Agency ... the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more people ... the Biggert-Waters Act was enacted to reflect the actual risk in flood zone ...
(Date:6/23/2017)... Dunmore, PA (PRWEB) , ... June 23, 2017 ... ... provides insurance management, financial planning, and related services to families and business owners ... for a charity drive to benefit senior citizens in the area. , Meals ...
Breaking Medicine News(10 mins):
(Date:6/10/2017)... June 9, 2017  Shane K. Burchfield, DPM, is recognized by ... as a Podiatrist in Alabama . ... First Foot Care. He brings over 20 years of experience, as ... and healthcare, to his role. ... PC is pleased to welcome you to his practice," ...
(Date:6/8/2017)... 2017   Responding to Heath Ledger,s father,s ... of singer Chris Cornell in May, the mental ... a free online psychiatric drug side effects ... about psychotropic drug risks. The father of ... an accidental overdose, has called for tighter rules on prescription ...
(Date:6/7/2017)... 6, 2017  Diplomat Specialty Infusion Group, a brand of Diplomat ... its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound intravenous ... low level of pollutants. "Our ... and better serve our Iowa patients," said ...
Breaking Medicine Technology:
Cached News: