HOME >> MEDICINE >> NEWS
High blood pressure drug promotes new blood vessel growth in lab animals, providing potential 'angiogenesis' treatment

DALLAS, June 15 -- A drug used to lower high blood pressure can stimulate the growth of new blood vessels in laboratory animals.

The findings, reported in today's Circulation: Journal of the American Heart Association, suggest that the drug, quinaprilat, may prove useful for treating people with severe chest pain (angina) and others at high risk of suffering a heart attack, says the study's senior author Jeffrey M. Isner, M.D., professor of medicine and pathology at Tufts University School of Medicine in Boston.

Quinaprilat, marketed as Acupril, is one of several drugs known as angiotensin-conversion-enzyme (ACE) inhibitors, which are used primarily to treat high blood pressure and congestive heart failure. These drugs block the activation of angiotensin, which in its active form causes blood vessels to constrict. When blood vessels are constricted, the heart has to pump harder to force blood through the body.

"The study demonstrates an unexpected function of a class of drugs that is commercially available and already has been shown to be safe to use. Quinaprilat deserves to be investigated for its potential use for promoting blood vessel growth," says Isner.

The study findings may explain previous reports that ACE inhibitors can benefit individuals who have reduced blood flow to their hearts that can cause chest pain, or angina, says Isner.

"One reason for the interest in this approach is that ACE inhibitors are drugs that can be taken orally," he adds. "If they work out for this kind of application, they would be easy for patients to use and potentially would be among the simplest strategies one could devise for promoting new blood vessel formation."

The growth of new blood vessels is called angiogenesis. In recent years, scientists have focused considerable attention on drugs and natural molecules in the body that promote or inhibit angiogenesis. Pro-angiogenesis treatments also could help people when leg blood vessels are ob
'"/>

Contact: Karen Hunter
khunter@heart.org
214-706-1330
American Heart Association
14-Jun-1999


Page: 1 2 3 4

Related medicine news :

1. A marker for new blood vessel formation in tumors
2. Acupuncture found to lower elevations in blood pressure
3. Diagnostic test for range of blood disorders on the horizon
4. Research suggests possible blood test for multiple sclerosis
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. Simple blood test may help to predict cardiovascular risk in older women
7. Drug that hinders blood vessel growth under study in ovarian cancer
8. Laughter helps blood vessels function better
9. St. Johns wort amplifies effect of blood thinner Plavix
10. Latest findings on genetic blood disorder Cooleys Anemia
11. Can routine commercial cord blood banking be scientifically and ethically justified?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & ... (TGIG), has initiated cultivation and processing operations at its production facility, and opened ... , Puradigm is the manufacturer of a complete system of proactive air and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
Breaking Medicine Technology:
Cached News: