HOME >> MEDICINE >> NEWS
High cholesterol and calcification are to blame for aortic valve disease

(CHICAGO) High cholesterol levels can lead to fatty deposits in the aortic valve. These deposits may induce undifferentiated cells to transform to bone-forming cells that calcify and narrow the aortic valve, according to researchers. Narrowing of the aortic valve is a common condition that causes the heart to have to squeeze harder to support normal blood flow, causing the heart muscle to enlarge and eventually fail. A study published today in Circulation authored by researchers at Northwestern and the Mayo Clinic is the first to explain the mechanism responsible for this process.

Aortic valvular disease is the most common reason for surgical valve replacement. No medical therapy has been proven to alter the progression of aortic valve disease. We conducted a test on laboratory model of aortic stenosis to determine whether high cholesterol led to the fatty deposits and resulting bone formation in the aortic valve and whether this progression could be controlled with the use of statins, explains lead author Nalini Rajamannan, MD, cardiologist, Northwestern Memorial Hospital and assistant professor of cardiology, The Feinberg School of Medicine at Northwestern University.

Our lab studies showed that statins greatly reduced the prevalence of the bone-forming cells and reduced the extent of changes in the aortic valve, said Dr. Rajamannan. Our findings, combined with recent retrospective clinical studies that showed that statins in patients slowed the rate of progression for aortic valve disease, point to possible benefits of using statins to treat patients with early stages of the aortic valve disease process. Earlier statin use may prolong the time to severe disease and the need for surgical valve replacement. Statins are drugs that block the formation of cholesterol in the liver and increase the production of the receptors on liver cells that clean the bad cholesterol from the blood.

We need to do large randomized trials using stat
'"/>

Contact: Amanda Widtfeldt
awidtfel@nmh.org
312-926-2955
Northwestern Memorial Hospital
3-Jun-2002


Page: 1 2

Related medicine news :

1. Boston University team finds link between high cholesterol and better cognitive performance
2. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
3. McGill researchers identify new way to reduce cholesterol levels
4. Researcher breaks down cholesterol mystery
5. American ethnic groups less likely to have cholesterol controlled
6. New Crestor data in African-American patients with high cholesterol
7. Nevirapine is better than efavirenz at raising good cholesterol
8. New way of controlling cholesterol may help treat Alzheimers
9. MRI can measure early benefits of cholesterol-lowering drugs and plaque reduction
10. Study supports aggressive treatment of heart patients with cholesterol-lowering medication
11. Blueberry compound shows promise of lowering cholesterol as effectively as drug

Post Your Comments:
(Date:4/26/2015)... Italian public health researchers have released new data ... and other asbestos-related industries. Surviving Mesothelioma has just posted ... to read it now. , University researchers ... Medicine analyzed more than 15,000 cases of mesothelioma between ... asbestos cancer was most common. , “Asbestos cement ...
(Date:4/26/2015)... (PRWEB) April 26, 2015 From March ... and his wife, Trivedi Master™ Dahryn Trivedi, spent a ... approved research laboratories and institutions in the efforts of ... medicine and nutraceutical supplements for human health care. ... different research labs and institutions. All lab facilities are ...
(Date:4/26/2015)... Rosa, CA (PRWEB) April 26, 2015 In ... from Washington State University evaluated the head-neck biomechanics occurring during ... of the study were able to determine that use of ... much as 3 to 5 times - more than when ... surprising outcome for such a study, but pointing out the ...
(Date:4/25/2015)... April 26, 2015 The National ... , a national endeavor to prepare nurses to provide ... a great success, according to a new report by ... original funding partners. , The project began in ... (CCP), under the direction of Elaine Tagliareni, EdD, RN, ...
(Date:4/25/2015)... The Hon. Ellen Tauscher, Independent Chair of the ... following the deadly earthquake in Nepal: , "Today a ... deaths of more than 1,000 people. The aftershocks ... India and other parts of South Asia. I ... of Nepal and the families of the victims. ...
Breaking Medicine News(10 mins):Health News:New Investigation Finds Mesothelioma “Clusters” Around Italian Cement Plants, According to Surviving Mesothelioma 2Health News:Trivedi Science™ Has Started Scientific Research to Create More Effective Pharmaceuticals and Nutraceuticals 2Health News:Trivedi Science™ Has Started Scientific Research to Create More Effective Pharmaceuticals and Nutraceuticals 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 3
(Date:4/24/2015)...  Perrigo Company plc ("Perrigo" or the "Company") (NYSE: ... offer from Mylan NV ("Mylan") (NASDAQ: MYL ) ... for $60.00 per share in cash and 2.2 Mylan ... The Board previously concluded that Mylan,s ... Company and its future growth prospects and was not ...
(Date:4/24/2015)... , April 24, 2015  IGI Laboratories, Inc. (NYSE ... based specialty generic pharmaceutical company, announced the Company will ... Tuesday, April 28, 2015 to discuss the 1st quarter ... listen to the call by dialing 1-888-346-3479. International participants ... should ask to be joined into the IGI Laboratories, ...
(Date:4/24/2015)...  Span-America Medical Systems, Inc. (NASDAQ:  SPAN) announced ... second quarter results on Thursday, April 30, after the ... will conduct a conference call at 10:00 a.m. ... financial and operating results for the second quarter ended ... conference call will be available online at ...
Breaking Medicine Technology:Perrigo Rejects Mylan Unsolicited Offer 2Perrigo Rejects Mylan Unsolicited Offer 3Perrigo Rejects Mylan Unsolicited Offer 4
Cached News: