HOME >> MEDICINE >> NEWS
High cholesterol and calcification are to blame for aortic valve disease

(CHICAGO) High cholesterol levels can lead to fatty deposits in the aortic valve. These deposits may induce undifferentiated cells to transform to bone-forming cells that calcify and narrow the aortic valve, according to researchers. Narrowing of the aortic valve is a common condition that causes the heart to have to squeeze harder to support normal blood flow, causing the heart muscle to enlarge and eventually fail. A study published today in Circulation authored by researchers at Northwestern and the Mayo Clinic is the first to explain the mechanism responsible for this process.

Aortic valvular disease is the most common reason for surgical valve replacement. No medical therapy has been proven to alter the progression of aortic valve disease. We conducted a test on laboratory model of aortic stenosis to determine whether high cholesterol led to the fatty deposits and resulting bone formation in the aortic valve and whether this progression could be controlled with the use of statins, explains lead author Nalini Rajamannan, MD, cardiologist, Northwestern Memorial Hospital and assistant professor of cardiology, The Feinberg School of Medicine at Northwestern University.

Our lab studies showed that statins greatly reduced the prevalence of the bone-forming cells and reduced the extent of changes in the aortic valve, said Dr. Rajamannan. Our findings, combined with recent retrospective clinical studies that showed that statins in patients slowed the rate of progression for aortic valve disease, point to possible benefits of using statins to treat patients with early stages of the aortic valve disease process. Earlier statin use may prolong the time to severe disease and the need for surgical valve replacement. Statins are drugs that block the formation of cholesterol in the liver and increase the production of the receptors on liver cells that clean the bad cholesterol from the blood.

We need to do large randomized trials using stat
'"/>

Contact: Amanda Widtfeldt
awidtfel@nmh.org
312-926-2955
Northwestern Memorial Hospital
3-Jun-2002


Page: 1 2

Related medicine news :

1. Boston University team finds link between high cholesterol and better cognitive performance
2. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
3. McGill researchers identify new way to reduce cholesterol levels
4. Researcher breaks down cholesterol mystery
5. American ethnic groups less likely to have cholesterol controlled
6. New Crestor data in African-American patients with high cholesterol
7. Nevirapine is better than efavirenz at raising good cholesterol
8. New way of controlling cholesterol may help treat Alzheimers
9. MRI can measure early benefits of cholesterol-lowering drugs and plaque reduction
10. Study supports aggressive treatment of heart patients with cholesterol-lowering medication
11. Blueberry compound shows promise of lowering cholesterol as effectively as drug

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2017)... British Columbia (PRWEB) , ... June 28, 2017 ... ... CNZCF) (FSE: ZEON) is pleased to announce that a two year study conducted ... the Company's Bromley Creek zeolite was successful in remediating potash brine-impacted groundwater. As ...
(Date:6/28/2017)... OH (PRWEB) , ... June 28, 2017 , ... ... of Hamilton County and the surrounding regions access to insurance assistance and financial ... with Matthew 25: Ministries to assist families in the region facing financial crisis. ...
(Date:6/28/2017)... Cincinnati, OH (PRWEB) , ... June 28, 2017 ... ... and financial consulting firm servicing communities throughout the greater Cincinnati metropolitan area, is ... help provide temporary lodgings for families with children receiving treatment in nearby hospitals. ...
(Date:6/27/2017)... ... June 27, 2017 , ... Nearly 70 ... survey data released today by the American Society for Dermatologic Surgery ... the percentage of consumers considering a cosmetic medical procedure has doubled since 2013. ...
(Date:6/27/2017)... ... , ... Harbour , a DAO (decentralized autonomous organization) that harnesses the ... their technical specifications . , 2017 has seen an explosion of token launches ... which offerings will garner the greatest ROI. Dean Eigenmann, Co-founder and CEO of Harbour, ...
Breaking Medicine News(10 mins):
(Date:6/27/2017)...  Therapix Biosciences Ltd. (Nasdaq: TRPX ) ... development of cannabinoid-based drugs, today announced that the Company ... New York, NY on Wednesday, ... offering (IPO) of American Depository Shares (ADSs) listed on ... Dr. Elran Haber, Ph.D., Chief Executive Officer of Therapix, ...
(Date:6/27/2017)... --  NuEyes (NuEyes Technologies Inc.) today announced that it ... in helping the legally blind live more independent lives. NuEyes works ... developer of augmented, virtual and mixed reality smartglasses and the ... funding amount was provided by strategic partners as well as ... Abu Dhabi , New York ...
(Date:6/20/2017)... Netherlands and LAGUNA HILLS, Calif. ... the presentation of new data that validate the use ... risk stratify patients with multiple myeloma (MM). In a ... the European Hematology Association (EHA) in Madrid, ... value of MMprofiler for identifying high-risk elderly patients. ...
Breaking Medicine Technology:
Cached News: