Holding Policy Is Cost-Effective Way To Further Protect Blood Plasma Supply From HIV And Other ...( ogy coupled with heat treatment which ...)

Holding Policy Is Cost-Effective Way To Further Protect Blood Plasma Supply From HIV And Other Infections

ogy, coupled with heat treatment which inactivates infections such as HIV, HBV, and HCV, has virtually eliminated the risk of infection with these diseases through blood plasma. Occasionally, plasma is collected that is potentially infectious, but not detected because the donor has not yet developed levels of HIV antibody (or p24 antigen) that can be identified by screening tests, the authors explain. This occurs when plasma is collected in donors who were recently infected with HIV. To eliminate the risk of transmission from these donations, blood plasma products are heat treated. There have been no cases of HIV transmission through blood plasma since heat treatment began.

To guard against the possibility of errors in plasma processing, the blood plasma industry has embarked on a comprehensive program to screen out the few potentially infectious units before processing. This program includes accepting only donations from repeat, qualified donors and implementation of the hold period. Under the type of holding policy described in the paper, all donated units are stored before being released for fractionation and the production of plasma products. If a donor tests positive for the infection in question at a subsequent donation, then all of that donor's units currently in storage are discarded. Otherwise, donated units are released for processing at the end of the holding period.

The study will be published in a forthcoming issue of the journal Mathematical Biosciences.

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Contact: Barry List
barry.list@informs.org
410-368-6580 pager
Institute for Operations Research and the Management Sciences
29-Apr-1999

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Holding Policy Is Cost-Effective Way To Further Protect Blood Plasma Supply From HIV And Other ...( ogy coupled with heat treatment which ...),Health