HOME >> MEDICINE >> NEWS
Hopkins Researchers Develop New Therapy For Autoimmune Disorders Such As Rheumatoid Arthritis And Lupus

Researchers at the Johns Hopkins Oncology Center used high doses of the chemotherapy drug cyclophosphamide alone to control previously untreatable forms of autoimmune disorders such as rheumatoid arthritis, lupus and hemolytic anemia.

Their findings are reported in the December 15, 1998 issue of Annals of Internal Medicine.

Of eight patients treated in the study with stand-alone high dose cyclophosphamide, five reported complete remissions and two achieved and maintained partial remissions. Four patients treated from six months to more than a year ago remain disease free, and two patients, in partial remission, continue to improve after more than a year. In addition, all patients were able to decrease their doses of medication, and three patients have completely discontinued medications for their disease. These patients had not responded to disease therapies and suffered from recurrent infections, persistent pain and kidney problems.

Treatment for severe autoimmune diseases using high-dose cyclophosphamide followed by bone marrow or stem cell transplantation to repopulate the immune system destroyed by the drug treatment is being studied elsewhere. The new Hopkins research, funded by the National Institutes of Health, suggests that transplants are unnecessary. "Stem cells, the marrow cells that reconstitute the immune system, are resistant to the drug and will repopulate in the marrow, without the need for transplantation," says Robert Brodsky, M.D., assistant professor of oncology and medicine and lead author of the study. "High-dose cyclophosphamide, without stem cell or bone marrow reinfusion, appears to be safer for the patient and avoids reinfusion of diseased immune cells," adds Brodsky, an American Society of Hematology Junior Faculty Scholar.

Hopkins scientists believe the cyclophosphamide works by reprogramming the immune system. "Immunity is learned' not inherited," explains Richard Jones, M.D., associat
'"/>

Contact: Vanessa Gatto
gattova@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
15-Dec-1998


Page: 1 2

Related medicine news :

1. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
2. Earlier use of prostate cancer vaccines urged by Hopkins scientists
3. Hopkins convenes consensus conference to develop blueprint for nationwide matching program
4. Johns Hopkins scientists receive presidential medals
5. Hopkins Institute for Global Tobacco Control receives elite recognition from PAHO/WHO
6. Hunt for autism genes to be led by Hopkins researchers
7. Most household cleaners remove peanut allergens, Hopkins study shows
8. Exercise Hypertension occurs when cells cant relax, Hopkins researchers find
9. Hopkins young researchers honored for their contributions
10. Hopkins researchers find MRI useful tool in diagnosing inflammatory bowel diseases in children
11. Hopkins Peter Agre receives 2003 Nobel Prize in chemistry

Post Your Comments:
(Date:8/30/2014)... "My wife suffered neck, back and spine injuries ... of two inventors from Bethel, Alaska. "The whiplash contributed ... area. She tried other pillows to little avail. The ... comfort and providing extra sleep." , They created a ... head, neck and back comfortably. This enables the user ...
(Date:8/30/2014)... 30, 2014 "My niece developed a ... at any moment, her fever might get worse," said ... me well aware of how she was doing, I ... ALARM to continuously monitor a child's temperature. The unit ... This ensures that prompt medical care can be given, ...
(Date:8/30/2014)... York (PRWEB) August 30, 2014 ... transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed against ... to sever four cases selected for one of ... issued on August 18, 2014, U.S. District Judge ... West Virginia disagrees with Boston Scientific’s contention that ...
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... August 30, 2014 Top10BestSEOHosting.com is ... researchers have announced that HostGator.com http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ... current market. Also, they has announced that Bluehost ... , Hostgator, one of the Top 10 ... of cheap Windows hosting, and it offers rich ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2
(Date:8/29/2014)... 2014 Medina Medical announced today that Mr. ... the Board of Directors on August 18, 2014. Mr. ... commercialization experience, including over a decade of direct experience ... a Partner of the medical device incubator The Foundry, ... Foundry start-ups. Mr. Engelson previously served as the Chief ...
(Date:8/29/2014)... 29, 2014 Research and Markets ... Cancer Therapeutics Market & Pipeline Insight 2014" report ... developed to prevent and eradicate the prevalence of cancer ... are confined to low specificity, safety and large number ... for a better solution. It has been discovered that ...
(Date:8/29/2014)... -- Research and Markets has announced the ... of Pharmaceutical Equipment Market in China, 2014-2018" report ... Trend Forecast of Pharmaceutical Equipment Market in ... pharmaceutical equipment industry in the aspects of ... business performance of domestic major enterprises, as well as ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
Cached News: