HOME >> MEDICINE >> NEWS
Hopkins Researchers Develop New Therapy For Autoimmune Disorders Such As Rheumatoid Arthritis And Lupus

Researchers at the Johns Hopkins Oncology Center used high doses of the chemotherapy drug cyclophosphamide alone to control previously untreatable forms of autoimmune disorders such as rheumatoid arthritis, lupus and hemolytic anemia.

Their findings are reported in the December 15, 1998 issue of Annals of Internal Medicine.

Of eight patients treated in the study with stand-alone high dose cyclophosphamide, five reported complete remissions and two achieved and maintained partial remissions. Four patients treated from six months to more than a year ago remain disease free, and two patients, in partial remission, continue to improve after more than a year. In addition, all patients were able to decrease their doses of medication, and three patients have completely discontinued medications for their disease. These patients had not responded to disease therapies and suffered from recurrent infections, persistent pain and kidney problems.

Treatment for severe autoimmune diseases using high-dose cyclophosphamide followed by bone marrow or stem cell transplantation to repopulate the immune system destroyed by the drug treatment is being studied elsewhere. The new Hopkins research, funded by the National Institutes of Health, suggests that transplants are unnecessary. "Stem cells, the marrow cells that reconstitute the immune system, are resistant to the drug and will repopulate in the marrow, without the need for transplantation," says Robert Brodsky, M.D., assistant professor of oncology and medicine and lead author of the study. "High-dose cyclophosphamide, without stem cell or bone marrow reinfusion, appears to be safer for the patient and avoids reinfusion of diseased immune cells," adds Brodsky, an American Society of Hematology Junior Faculty Scholar.

Hopkins scientists believe the cyclophosphamide works by reprogramming the immune system. "Immunity is learned' not inherited," explains Richard Jones, M.D., associat
'"/>

Contact: Vanessa Gatto
gattova@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
15-Dec-1998


Page: 1 2

Related medicine news :

1. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
2. Earlier use of prostate cancer vaccines urged by Hopkins scientists
3. Hopkins convenes consensus conference to develop blueprint for nationwide matching program
4. Johns Hopkins scientists receive presidential medals
5. Hopkins Institute for Global Tobacco Control receives elite recognition from PAHO/WHO
6. Hunt for autism genes to be led by Hopkins researchers
7. Most household cleaners remove peanut allergens, Hopkins study shows
8. Exercise Hypertension occurs when cells cant relax, Hopkins researchers find
9. Hopkins young researchers honored for their contributions
10. Hopkins researchers find MRI useful tool in diagnosing inflammatory bowel diseases in children
11. Hopkins Peter Agre receives 2003 Nobel Prize in chemistry

Post Your Comments:
(Date:2/27/2015)... On February 24 2015, Harper’s Bazaar Magazine posted an ... details the development of RT001, a form of topical botulinum ... trials. For those afraid of needles, the idea of a ... if the drug ultimately gets FDA approval it will be ... , “As the article notes, the size of the ...
(Date:2/27/2015)... 27, 2015 Adding to its ... pharmaceuticals, Benedict Advertising & Marketing has added Sedation ... The company’s patented NITROUSEAL® N20 closed mask and ... of sedation. , Sedation Systems, http://www.sedationsystems.com ... a new level, though it focuses primarily on ...
(Date:2/27/2015)... NY (PRWEB) February 27, 2015 The winter ... mold growth and expansion. When mold grows, it can be ... be sure to avoid the consequences of mold growth with ... Long Island, is offering tips on the best ways to ... wet season, which makes perfect conditions for mold to thrive. ...
(Date:2/27/2015)... Vancouver, BC (PRWEB) February 27, 2015 ... exciting overnight deals for couples who wanted to spend ... with the opportunity to get a jump on Valentine’s ... meal and stay in one of their luxurious rooms. ... on February 13, inviting guests for a mouthwatering 3 ...
(Date:2/27/2015)... Florida Hospital North Pinellas is being ... Gold Plus hospital. In order to receive the award, ... to all Get With The Guidelines - Stroke Quality ... and achieved 75-percent or higher compliance with six of ... These are reporting initiatives to measure quality of care. ...
Breaking Medicine News(10 mins):Health News:Is Topical Botox the Next Big Thing? 2Health News:Benedict Advertising & Marketing Signs Sedation Systems 2Health News:Enviro-Test Offers Tips for Winter Mold Prevention 2Health News:Victorian Hotel Celebrated Valentine’s Day in 2015 With Unique Overnight Deal 2Health News:Florida Hospital North Pinellas Receives Get With The Guidelines - Stroke Gold Plus Quality Achievement Award 2
(Date:2/27/2015)... Feb. 27, 2015  PTC Therapeutics, Inc. (NASDAQ: ... reported financial results for the fourth quarter and full ... was a transformative year for PTC. We are now ... developing RNA-targeted therapies in the rare disease space," stated ... Inc. "We are proud to bring the first treatment ...
(Date:2/27/2015)... 2015  Bionik Laboratories Corp. (OTC:DWTPD), a ... it acquired Bionik Laboratories, Inc., a Toronto ... to qualified accredited investors of units consisting of its ... approximately $6.2 million. Shares of the Company,s common stock ... under the symbol "DWTPD" until FINRA,s approval of the ...
(Date:2/26/2015)... -- RnRMarketResearch.com adds Corneal Ulcers - ... its store. This report p provides an overview ... The report "Corneal Ulcers - Pipeline Review, H2 2014" provides ... Ulcers. Corneal Ulcers are primarily result of the ... & fungal infections. The symptoms of the corneal ...
Breaking Medicine Technology:PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 10PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 11Bionik Laboratories Raises $6.2 Million 2Bionik Laboratories Raises $6.2 Million 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5
Cached News: