HOME >> MEDICINE >> NEWS
Hopkins Researchers Develop New Therapy For Autoimmune Disorders Such As Rheumatoid Arthritis And Lupus

Researchers at the Johns Hopkins Oncology Center used high doses of the chemotherapy drug cyclophosphamide alone to control previously untreatable forms of autoimmune disorders such as rheumatoid arthritis, lupus and hemolytic anemia.

Their findings are reported in the December 15, 1998 issue of Annals of Internal Medicine.

Of eight patients treated in the study with stand-alone high dose cyclophosphamide, five reported complete remissions and two achieved and maintained partial remissions. Four patients treated from six months to more than a year ago remain disease free, and two patients, in partial remission, continue to improve after more than a year. In addition, all patients were able to decrease their doses of medication, and three patients have completely discontinued medications for their disease. These patients had not responded to disease therapies and suffered from recurrent infections, persistent pain and kidney problems.

Treatment for severe autoimmune diseases using high-dose cyclophosphamide followed by bone marrow or stem cell transplantation to repopulate the immune system destroyed by the drug treatment is being studied elsewhere. The new Hopkins research, funded by the National Institutes of Health, suggests that transplants are unnecessary. "Stem cells, the marrow cells that reconstitute the immune system, are resistant to the drug and will repopulate in the marrow, without the need for transplantation," says Robert Brodsky, M.D., assistant professor of oncology and medicine and lead author of the study. "High-dose cyclophosphamide, without stem cell or bone marrow reinfusion, appears to be safer for the patient and avoids reinfusion of diseased immune cells," adds Brodsky, an American Society of Hematology Junior Faculty Scholar.

Hopkins scientists believe the cyclophosphamide works by reprogramming the immune system. "Immunity is learned' not inherited," explains Richard Jones, M.D., associat
'"/>

Contact: Vanessa Gatto
gattova@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
15-Dec-1998


Page: 1 2

Related medicine news :

1. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
2. Earlier use of prostate cancer vaccines urged by Hopkins scientists
3. Hopkins convenes consensus conference to develop blueprint for nationwide matching program
4. Johns Hopkins scientists receive presidential medals
5. Hopkins Institute for Global Tobacco Control receives elite recognition from PAHO/WHO
6. Hunt for autism genes to be led by Hopkins researchers
7. Most household cleaners remove peanut allergens, Hopkins study shows
8. Exercise Hypertension occurs when cells cant relax, Hopkins researchers find
9. Hopkins young researchers honored for their contributions
10. Hopkins researchers find MRI useful tool in diagnosing inflammatory bowel diseases in children
11. Hopkins Peter Agre receives 2003 Nobel Prize in chemistry

Post Your Comments:
(Date:3/27/2015)... 2015 Wellness for Cancer–the first organization ... for the spa and wellness industry–has certified Hands On ... experienced or are living with cancer. Hands On ... Network, will be identified with a special Wellness for ... of safe, therapeutic services for cancer patients. , Wellness ...
(Date:3/27/2015)... In her mid-forties and with a lifelong speech ... K. arrived at JET Uniform & Supply for ... scared. The owners and staff at JET, which had partnered ... offer jobs to challenged residents like Monica, were patient. ... begin with the end in mind,” says Stephen Milaney, co-owner ...
(Date:3/27/2015)... March 27, 2015 Florida Hospital is excited ... the team’s exclusive health care provider for the 2015 and ... Hospital provides medical care and an athletic trainer for the ... kick off its season against the Cleveland Gladiators at Amalie ... partnership is extremely important to us as it gives us ...
(Date:3/27/2015)... New York (PRWEB) March 27, 2015 ... http://www.lipitorlawsuitcenter.com/ ) that allege the statin medication increases the ... has granted Pfizer Inc.’s Motion to Dismiss four individual ... to a Case Management Order issued in the U.S. ... the Court determined that the dismissals were warranted because ...
(Date:3/27/2015)... First Choice Emergency Room opened its new Summerwood ... W Lake Houston Pkwy, Houston, Texas and is open 24-7. ... to delivering the highest quality emergency medical care to my ... Choice Emergency Room Summerwood. , To celebrate the ... Creek High School at First Choice Emergency Room’s ribbon cutting ...
Breaking Medicine News(10 mins):Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 4Health News:Red Deer Uniforms Shop Celebrates 3rd Year Sewing Hope for the Challenged 2Health News:Red Deer Uniforms Shop Celebrates 3rd Year Sewing Hope for the Challenged 3Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2
(Date:3/27/2015)... 2015  Holographic Optical Technologies of Augusta, ... medical imaging, is entering the world of consumer electronics ... April 20 th , 2015, the campaign will introduce ... and 22-inch displays will allow consumers to view fully ... In addition to the two displays, the company will ...
(Date:3/27/2015)... , March 27, 2015 A new report from ... America – Chile , ... are top targets for IVD firms.  The healthcare research firm ... into IVD strategies for the Latin American continent with a ... globally distributed supply operations. However, the country,s regional economic clout ...
(Date:3/27/2015)... Report Details  New study shows ... What does the future hold for top companies ... new report shows you potential revenues to 2025, assessing ... 242-page report provides 185 tables, charts, and graphs. Discover ... future market prospects. Our new study lets you assess ...
Breaking Medicine Technology:Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7
Cached News: