HOME >> MEDICINE >> NEWS
Hormone prompts adult stem cells to differentiate into islet cells

Scientists at Massachusetts General Hospital (MGH) have discovered that a naturally occurring hormone can cause adult islet stem cells to mature into pancreatic beta cells, the insulin-secreting cells that are depleted or compromised in diabetes. The results, which appear in the August issue of Endocrinology, could help researchers design a strategy for reversing the disease.

"These findings are important because, in diabetes, beta cells in the pancreas have a limited if any capacity to proliferate, and they die at a steady rate," says Joel Habener, MD, of the MGH Laboratory of Molecular Endocrinology and an investigator with the Howard Hughes Medical Institute, the paper?s senior author.

Type 1 diabetes is caused by destruction of insulin-producing beta cells of the pancreas in a mistaken attack by the body?s immune system. As a result, patients do not produce the insulin required for proper glucose metabolism and need to take insulin injections. In type 2 diabetes, the most common form of the disease, patient' beta cells do not produce enough insulin at the right time during a meal, and their overall metabolism does not respond correctly to insulin. As a result, their blood glucose levels rise. This so-called hyperglycemia can exert further deleterious effects on beta cells. For both types of diabetes, finding new ways to provide functioning beta cells has been an area of great interest for researchers.

One current strategy being explored for treating type 1 diabetes is transplantation of beta cells, but these cells are in limited supply and may be rejected by the patients' immune systems. Therefore, finding alternative sources of insulin-secreting cells is necessary.

Clinical trials have shown that an intestinal hormone called glucagon-like peptide-1 (GLP-1) can provoke beta cells to proliferate and to secrete insulin. Habener and his laboratory now provide evidence that the hormone may also cause islet stem cells to d
'"/>

Contact: Susan McGreevey
smcgreevey@partners.org
617-724-2765
Massachusetts General Hospital
17-Jul-2002


Page: 1 2

Related medicine news :

1. Hormone therapy increases risk of urinary incontinence
2. Hormone therapy controversy raises drug safety issues
3. Endocrine Society and Hormone Foundation call for increased research
4. Hormone therapy may still offer important health benefits to postmenopausal women
5. Hormone may offer hope for treating some behavioral disorders
6. Hormone found to protect bones
7. Hormone released by bone marrow cells may hasten recovery from brain injury
8. Hormones increase side effects, complicate treatment decision for prostate cancer patients
9. Hormones and drugs that control blood pressure also control malaria infection
10. Hormone replacement therapy reviewing the evidence
11. Hormone therapy study stopped due to increased breast cancer risk, lack of overall benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2020)... ... March 21, 2020 , ... In partnership with UC Health, ... our community’s medical professionals and first responders. The title comes from the English translation ... city and its flag. , Proceeds from the sale of the shirt will ...
(Date:3/20/2020)... DALLAS (PRWEB) , ... March 20, 2020 , ... ... for their medical clinics. The virtual waiting room lets patients present online, complete ... place in the queue, wait for their turn, and get signaled that their clean ...
(Date:3/19/2020)... ... 2020 , ... Sucheta Kamath, Founder and CEO of ExQ®, ... Learning Exercise: ExQ® Superpower Hour. During the recent closure of many ... with the immediate need for activities that can be implemented at home, and ...
(Date:3/16/2020)... GREENWICH, Conn. and LEE’S SUMMIT, Mo. (PRWEB) , ... ... ... (NKR) and Viracor Eurofins announced a partnership today to deliver testing for Coronavirus ... Centers. NKR is the largest paired exchange program in the world and serves ...
(Date:3/15/2020)... ... March 14, 2020 , ... ... of confusing information surrounding the Coronavirus (COVID-19) pandemic, National HouseCheck Corporation (‘HouseCheck’) ... concerns of businesses and employees. HouseCheck has launched its nationwide Virus Remediation ...
Breaking Medicine News(10 mins):
(Date:3/19/2020)... SILVER SPRING, Md. (PRWEB) , ... March 19, ... ... Tufts Medical Center in Boston; Cleveland Clinic in Cleveland; ... Jewish Health in Denver have received accreditation as PHA Centers of Comprehensive ...
(Date:3/16/2020)... ... March 16, 2020 , ... ... education platform, with content available from numerous organizations. Docola enables healthcare providers ... support patients before, after, or between face-to-face visits or on telemedicine appointments. ...
(Date:3/16/2020)... ... 16, 2020 , ... The American Academy of Allergy, Asthma ... MD, MSPH, FAAAAI. , The AAAAI is the largest professional membership organization ... special interest in the research and treatment of allergic and immunologic diseases, including ...
Breaking Medicine Technology:
Cached News: