Hormone prompts adult stem cells to differentiate into islet cells

Scientists at Massachusetts General Hospital (MGH) have discovered that a naturally occurring hormone can cause adult islet stem cells to mature into pancreatic beta cells, the insulin-secreting cells that are depleted or compromised in diabetes. The results, which appear in the August issue of Endocrinology, could help researchers design a strategy for reversing the disease.

"These findings are important because, in diabetes, beta cells in the pancreas have a limited if any capacity to proliferate, and they die at a steady rate," says Joel Habener, MD, of the MGH Laboratory of Molecular Endocrinology and an investigator with the Howard Hughes Medical Institute, the paper?s senior author.

Type 1 diabetes is caused by destruction of insulin-producing beta cells of the pancreas in a mistaken attack by the body?s immune system. As a result, patients do not produce the insulin required for proper glucose metabolism and need to take insulin injections. In type 2 diabetes, the most common form of the disease, patient' beta cells do not produce enough insulin at the right time during a meal, and their overall metabolism does not respond correctly to insulin. As a result, their blood glucose levels rise. This so-called hyperglycemia can exert further deleterious effects on beta cells. For both types of diabetes, finding new ways to provide functioning beta cells has been an area of great interest for researchers.

One current strategy being explored for treating type 1 diabetes is transplantation of beta cells, but these cells are in limited supply and may be rejected by the patients' immune systems. Therefore, finding alternative sources of insulin-secreting cells is necessary.

Clinical trials have shown that an intestinal hormone called glucagon-like peptide-1 (GLP-1) can provoke beta cells to proliferate and to secrete insulin. Habener and his laboratory now provide evidence that the hormone may also cause islet stem cells to d

Contact: Susan McGreevey
Massachusetts General Hospital

Page: 1 2

Related medicine news :

1. Hormone therapy increases risk of urinary incontinence
2. Hormone therapy controversy raises drug safety issues
3. Endocrine Society and Hormone Foundation call for increased research
4. Hormone therapy may still offer important health benefits to postmenopausal women
5. Hormone may offer hope for treating some behavioral disorders
6. Hormone found to protect bones
7. Hormone released by bone marrow cells may hasten recovery from brain injury
8. Hormones increase side effects, complicate treatment decision for prostate cancer patients
9. Hormones and drugs that control blood pressure also control malaria infection
10. Hormone replacement therapy reviewing the evidence
11. Hormone therapy study stopped due to increased breast cancer risk, lack of overall benefit

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... ... impairment, has announced the Best Memory Care Facilities in Louisville, KY. The guide ... and amenities. , According to the Alzheimer’s Association , 5.6 million ...
(Date:9/1/2020)... ... , ... Feeding Matters , the first organization in the world dedicated ... pleased to announce that the U.S. Centers for Disease Control and Prevention (CDC) has ... edition of the U.S. International Classification of Diseases (ICD ) on October 1, ...
(Date:8/31/2020)... ... ... dear friend has cancer? , It’s hard to hear your doctor say the words “You ... shock wears off, the questions and fears can be overwhelming. , How should I respond? ... are failing me. I’m scared. I want to DO something. , We’ve talked to experts ...
(Date:8/31/2020)... ... 2020 , ... Smile Brands Inc., one of the nation’s ... today announced the grand opening of another affiliated Bright Now! Dental office ... hours, a comfortable office, and full-service care at the new Beaumont location. The ...
(Date:8/31/2020)... Conn. (PRWEB) , ... August 31, 2020 , ... ... device intended to improve outcomes for patients with advanced heart failure, today announced ... (SBIR) grant in the amount of $555,358 from the National Heart, Lung, and ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... (PRWEB) , ... September 03, 2020 , ... Using Analysis ... FDAnews Webinar, Thursday, Sept. 17, 2020, 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/anova , ... expert statistician? , While one can’t become one in 90 minutes, one can ...
(Date:9/2/2020)... ... September 02, 2020 , ... ... , Advanced Penetration Technology, LLC, (APT) a Texas- and Indiana-based company ( ... Over The Counter (OTC) products, was today provided results of an independent ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... Cosmetics and Laser Surgery at the University of Rochester Medical Center, in Upstate ... SkinCare Physicians in Boston, with clinical faculty from the Harvard and Yale Departments ...
Breaking Medicine Technology:
Cached News: