The laboratory study was published in the January 2004 issue of the journal Experimental Neurology.
"We're suggesting that transplanted bone marrow stromal cells may hasten recovery by releasing brain natriuretic peptide and other factors that improve blood flow to the brain and decrease swelling and pressure around the site of injury," said lead investigator Juan Sanchez-Ramos, MD, PhD, professor of neurology and research director at the USF Center for Aging and Brain Repair. "By helping irrigate, or restore the blood circulation to the brain, brain natriuretic factor may reduce the extent of damage from stroke or spinal cord injuries."
Researchers at USF and other institutions have demonstrated that some cells from adult bone marrow can be converted with growth factors and other agents into immature nerve cells -- both in the laboratory and following transplant into animals. Furthermore, rats suffering from stroke or other traumatic brain injury recover neurological function quicker following intravenous infusions of bone marrow stromal cells.
However, no one has proven that this recovery results from converted bone marrow cells directly replacing or repairing damaged neurons. A growing number of scientists, including Dr. Sanchez-Ramos, hypothesize that growth factors, cytokines and other substances secreted by bone marrow cells may play a more important role than first realized in recovery from neurological injuries.