Hormone therapy increases risk of urinary in...( trogen and progestin or estrogen alone ...),Health

The researchers found that menopausal hormone therapy increased the incidence of all types of UI at 1 year among women who were continent at baseline. The risk was highest for stress UI (1.87-fold increased risk with CEE + MPA; CEE alone, 2.15-fold increased risk), followed by mixed UI (1.49-fold increased risk with CEE + MPA; CEE alone, 1.79-fold increased risk). The combination of CEE + MPA had no significant effect on developing urge UI, but CEE alone increased the risk by 1.32 fold. Among women who reported having UI at baseline, both frequency and amount of UI worsened in both trials. Women receiving menopausal hormone therapy were more likely to report that UI limited their daily activities and bothered or disturbed them at 1 year.

"In conclusion, these results from a large, double-blind, placebo-controlled, randomized clinical trial, conducted in multiple centers with an ethnically diverse group of healthy postmenopausal women, indicate that MHT use does not confer protection against any type of UI. On the contrary, both CEE alone and CEE + MPA increased risk of new onset UI among continent women and worsened the characteristics of UI among symptomatic women. Considerations regarding the use of hormone therapy by postmenopausal women for any duration should incorporate the current findings into the established risks and benefits of these agents," the authors conclude.

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Contact: Jennifer Day
313-577-1429
JAMA and Archives Journals
22-Feb-2005