Hormone therapy may still offer important health benefits to postmenopausal women

"Subtle differences in hormone structure and subtle differences in cells can make a tremendous difference in outcome. This is why the effects of the specific estrogens and progestin used in the Women's Health Initiative may not apply to all estrogens and progestins," said Turgeon, who has done extensive research on steroid hormone action. "If we base all our conclusions on a single formulation, we are missing health benefits that may be conferred by different formulations and treatment regimens."

The researchers point out that how a drug is administered by pill or patch, for example -- can also be critical to how it affects the body. For example, when estrogen is taken as a pill, as in the Women's Health Initiative study, it must first be processed through the liver, which responds by producing several proteins, some of which are associated with a higher risk of heart disease. However, when estradiol is administered through the skin with a transdermal patch, these proteins are not affected.

"More fundamental research of the roles of hormones in specific tissues are needed, and more clinical studies of different formulations and ways of administering the drugs are essential," said Turgeon. "A current thrust of pharmaceutical research is to create slightly different estrogen or progestin molecules to select for the biological effects we want to enhance." The other authors of the Science article are Donald P. McDonnell of Duke University Medical Center and Kathryn A. Martin of Harvard Medical School.


Contact: Carole Gan
University of California, Davis - Health System

Page: 1 2 3

Related medicine news :

1. Hormone therapy increases risk of urinary incontinence
2. Hormone therapy controversy raises drug safety issues
3. Endocrine Society and Hormone Foundation call for increased research
4. Hormone may offer hope for treating some behavioral disorders
5. Hormone found to protect bones
6. Hormone released by bone marrow cells may hasten recovery from brain injury
7. Hormones increase side effects, complicate treatment decision for prostate cancer patients
8. Hormones and drugs that control blood pressure also control malaria infection
9. Hormone replacement therapy reviewing the evidence
10. Hormone prompts adult stem cells to differentiate into islet cells
11. Hormone therapy study stopped due to increased breast cancer risk, lack of overall benefit

Post Your Comments:

(Date:3/19/2020)... ... March 19, 2020 , ... Sucheta Kamath, Founder and CEO ... free Student Learning Exercise: ExQ® Superpower Hour. During the recent closure ... to help with the immediate need for activities that can be implemented at ...
(Date:3/19/2020)... ... March 20, 2020 , ... With ICH E8(R1) set to ... look different than they do today. Be ready to implement the new guidelines. ... shows readers how to leverage the revised guidelines’ quality-by-design approaches, expanded study designs and ...
(Date:3/15/2020)... ... March 13, 2020 , ... Special ... mission to bridge the gap by connecting individuals with autism and other developmental ... to attain fulfilling and independent lives has not wavered. , These past ...
(Date:3/13/2020)... ... , ... The Berman Law Group today announced that it has filed a ... of Wuhan, and several Chinese government ministries, on behalf of residents and businesses in ... Southern District of Florida, and seeks billions of dollars in compensatory damages for those ...
(Date:3/13/2020)... ANGELES (PRWEB) , ... March 13, 2020 , ... Ship Smart, a company specializing in ... moving to and from colleges , dorms, universities and schools for over 20 years. ... at the pick up location, Ship Smart is willing to pick up their belongings as ...
Breaking Medicine News(10 mins):
(Date:3/20/2020)... PARAMUS, N.J. (PRWEB) , ... March 20, 2020 , ... ... have a successful and productive life, as well as encourages those interested in pursuing ... parents and students is whether adolescents who attend the school have a good chance ...
(Date:3/16/2020)... , ... March 16, 2020 ... ... has now integrated with six medical billing and Electronic Health Record (EHR) ... Ascend and R2 Health. Multiple other EHR integrations are underway, including CareCloud, ...
(Date:3/16/2020)... , ... March 16, 2020 , ... ... to introduce its 2020-2021 President, Mary Beth Fasano, MD, MSPH, FAAAAI. , ... allied health and related healthcare professionals—all with a special interest in the research ...
Breaking Medicine Technology:
Cached News: