HOME >> MEDICINE >> NEWS
Hospital researchers identify gene important in certain cancers

Researchers at the Womens and Childrens Hospital, Adelaide have identified the FOR gene located on chromosome 16. This gene was found to have an important role in controlling when cells should divide.

Associate Professor Rob Richards who heads this research team at the hospital says, Mutations in certain genes are critical in causing cancer. Specific areas on our chromosomes are unstable in cancer cells and genetic material is thought to be particularly unstable in regions known also as fragile sites.

Of the 100 or so fragile sites in the human genome, we now know that one, the FRA16D fragile site, can be deleted in cancers of the stomach, colon, lung, breast and ovary.

Our team has sequenced this fragile site and identified the FOR gene (short for Fragile Site OxidoReductase) as the main area of instability in the DNA (1,2). The FOR gene was found to code for multiple proteins. The gene is affected in various cancers including some cases of multiple myeloma, Associate Professor Richards says.

Following on from the Womens and Childrens Hospitals identification of the FOR gene, a US research group(3)has found a function for one of the proteins produced by the FOR gene. The US studies have shown that one of these proteins enables cells to be more readily killed by tumour necrosis factor produced by the human body in response to infection and other conditions. If this FOR protein is not being produced, tumour cells are more likely to escape killing by the bodys defences.

This same FOR protein was also found to be an essential partner to a second protein called p53 also involved in cancer. The p53 helps monitor DNA damage and puts a brake on cell division to enable the mutation to be repaired before the cell continues dividing. In this way mutations are not passed onto offspring cells. If either this FOR protein or p53 are absent due to deletion/mutation of their respective genes, then mutated cells can divide and proliferate unchecked, all
'"/>

Contact: Dr Edna Bates
batese@wch.sa.gov.au
618-8204- 7388
Women's and Children's Hospital, Adelaide - Part of the Children, Youth and Women's Health Service
4-Mar-2001


Page: 1 2

Related medicine news :

1. Hospital acquired infections present major problem for infants in developing countries
2. Hospitals may now be more willing to partner up with former adversaries
3. Northwestern Memorial Hospital honored with one of the nations top awards for quality
4. Society of Hospital Medicine to launch new medical journal
5. Surgeon General at Childrens Hospital & Research Center at Oakland
6. Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
7. Childrens Hospital Oakland opens new $5.6 million infectious disease lab
8. Brenner Childrens Hospital named to NIH Pediatric Heart Network
9. Hospital admissions for asthma more likely for ethnic minorities in the UK
10. Society of Hospital Medicine selects John Wiley & Sons, Inc. to publish The Hospitalist Newsletter
11. Childrens Hospital at Vanderbilt ranked 8th in nation by Child magazine

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hospital researchers identify gene important certain cancers

(Date:7/22/2014)... Plate Club you eat pretty much everything you put ... Cornell University study shows that the average adult eats 92% ... plate. "If you put it on your plate, ... of the forthcoming book, Slim by Design, Professor of Marketing ... Wansink and co-author Katherine Abowd Johnson analyzed 1179 diners and ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 As reported on ... a caller request to name her favorite beauty products, “ ... on to say that “ Botox has changed my ... the makeup chair preparing for her various, daily appearances. ... explained Ms. Ripa (see: goo.gl/shmTQM). , “I think that Kelly ...
(Date:7/22/2014)... The Beryl Institute announces its fifth ... Scholar Program. These offerings reinforce the Institute’s commitment to ... healthcare and the need for rigorous research to understand ... scholar programs are intended to encourage and support ... focusing on the patient experience before, during and after ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 The market ... the past few years, owing to novel medical indications ... BoNTs in the aging societies where physical appearance is ... by one player, current competitors, new companies and technologies ... As biosimilar BoNTs will put the price of 1st-gen ...
(Date:7/22/2014)... NJ (PRWEB) July 22, 2014 CarePoint Health ... recently elected as the President of the medical staff at ... Levine will serve as President, as voted on by the ... of the medical staff in relation to the administration at ... needs of physicians and to work to make the Medical ...
Breaking Medicine News(10 mins):Health News:Celebrity Botox: Kelly Ripa Confesses to Getting Botox Injections 2Health News:The Beryl Institute Opens Applications for 2014 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2014 Patient Experience Grant and Scholar Programs 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 2Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 4Health News:Dr. Howard Levine Elected President of the Medical Staff at Bayonne Medical Center 2
(Date:7/22/2014)... , July 22, 2014  NeuroSigma, Inc. (NeuroSigma), ... focused on commercialization of its non-invasive Monarch ... and neuropsychiatric disorders, today announced that enrollment has begun ... nerve stimulation (eTNS) as adjunctive therapy for the treatment ... being conducted at the Olive View-UCLA Medical Center in ...
(Date:7/22/2014)... York , July 22, 2014 ... Partnerschaft für umfassenden Schutz von Pharmazeuten ... Österreich    Equashield ( ... Transfersystemen (Closed System Transfer Devices, CSTDs) für gefährliche ... einen Vertriebshändler und Hersteller von medizinischen ...
(Date:7/21/2014)... McCord Research, Inc. was recently granted ... This patent describes a method for accelerating wound ... inventor, Dr. McCord, this method includes administering or ... composition of an effective amount of hydroxytyrosol and ... such that the administration of the combination reduces ...
Breaking Medicine Technology:Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 2Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 3Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 4Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 5Equashield ernennt Medikus zu seinem exklusiven österreichischen Vertriebspartner für seine geschlossenen Arzneimitteltransfersysteme 2US Patent Office Grants McCord Research Endothelial Cell Treatment Patent 2
Cached News: