HOME >> MEDICINE >> NEWS
Hospital researchers identify gene important in certain cancers

Researchers at the Womens and Childrens Hospital, Adelaide have identified the FOR gene located on chromosome 16. This gene was found to have an important role in controlling when cells should divide.

Associate Professor Rob Richards who heads this research team at the hospital says, Mutations in certain genes are critical in causing cancer. Specific areas on our chromosomes are unstable in cancer cells and genetic material is thought to be particularly unstable in regions known also as fragile sites.

Of the 100 or so fragile sites in the human genome, we now know that one, the FRA16D fragile site, can be deleted in cancers of the stomach, colon, lung, breast and ovary.

Our team has sequenced this fragile site and identified the FOR gene (short for Fragile Site OxidoReductase) as the main area of instability in the DNA (1,2). The FOR gene was found to code for multiple proteins. The gene is affected in various cancers including some cases of multiple myeloma, Associate Professor Richards says.

Following on from the Womens and Childrens Hospitals identification of the FOR gene, a US research group(3)has found a function for one of the proteins produced by the FOR gene. The US studies have shown that one of these proteins enables cells to be more readily killed by tumour necrosis factor produced by the human body in response to infection and other conditions. If this FOR protein is not being produced, tumour cells are more likely to escape killing by the bodys defences.

This same FOR protein was also found to be an essential partner to a second protein called p53 also involved in cancer. The p53 helps monitor DNA damage and puts a brake on cell division to enable the mutation to be repaired before the cell continues dividing. In this way mutations are not passed onto offspring cells. If either this FOR protein or p53 are absent due to deletion/mutation of their respective genes, then mutated cells can divide and proliferate unchecked, all
'"/>

Contact: Dr Edna Bates
batese@wch.sa.gov.au
618-8204- 7388
Women's and Children's Hospital, Adelaide - Part of the Children, Youth and Women's Health Service
4-Mar-2001


Page: 1 2

Related medicine news :

1. Hospital acquired infections present major problem for infants in developing countries
2. Hospitals may now be more willing to partner up with former adversaries
3. Northwestern Memorial Hospital honored with one of the nations top awards for quality
4. Society of Hospital Medicine to launch new medical journal
5. Surgeon General at Childrens Hospital & Research Center at Oakland
6. Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
7. Childrens Hospital Oakland opens new $5.6 million infectious disease lab
8. Brenner Childrens Hospital named to NIH Pediatric Heart Network
9. Hospital admissions for asthma more likely for ethnic minorities in the UK
10. Society of Hospital Medicine selects John Wiley & Sons, Inc. to publish The Hospitalist Newsletter
11. Childrens Hospital at Vanderbilt ranked 8th in nation by Child magazine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology:
Cached News: