HOME >> MEDICINE >> NEWS
Hospital researchers identify gene important in certain cancers

Researchers at the Womens and Childrens Hospital, Adelaide have identified the FOR gene located on chromosome 16. This gene was found to have an important role in controlling when cells should divide.

Associate Professor Rob Richards who heads this research team at the hospital says, Mutations in certain genes are critical in causing cancer. Specific areas on our chromosomes are unstable in cancer cells and genetic material is thought to be particularly unstable in regions known also as fragile sites.

Of the 100 or so fragile sites in the human genome, we now know that one, the FRA16D fragile site, can be deleted in cancers of the stomach, colon, lung, breast and ovary.

Our team has sequenced this fragile site and identified the FOR gene (short for Fragile Site OxidoReductase) as the main area of instability in the DNA (1,2). The FOR gene was found to code for multiple proteins. The gene is affected in various cancers including some cases of multiple myeloma, Associate Professor Richards says.

Following on from the Womens and Childrens Hospitals identification of the FOR gene, a US research group(3)has found a function for one of the proteins produced by the FOR gene. The US studies have shown that one of these proteins enables cells to be more readily killed by tumour necrosis factor produced by the human body in response to infection and other conditions. If this FOR protein is not being produced, tumour cells are more likely to escape killing by the bodys defences.

This same FOR protein was also found to be an essential partner to a second protein called p53 also involved in cancer. The p53 helps monitor DNA damage and puts a brake on cell division to enable the mutation to be repaired before the cell continues dividing. In this way mutations are not passed onto offspring cells. If either this FOR protein or p53 are absent due to deletion/mutation of their respective genes, then mutated cells can divide and proliferate unchecked, all
'"/>

Contact: Dr Edna Bates
batese@wch.sa.gov.au
618-8204- 7388
Women's and Children's Hospital, Adelaide - Part of the Children, Youth and Women's Health Service
4-Mar-2001


Page: 1 2

Related medicine news :

1. Hospital acquired infections present major problem for infants in developing countries
2. Hospitals may now be more willing to partner up with former adversaries
3. Northwestern Memorial Hospital honored with one of the nations top awards for quality
4. Society of Hospital Medicine to launch new medical journal
5. Surgeon General at Childrens Hospital & Research Center at Oakland
6. Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
7. Childrens Hospital Oakland opens new $5.6 million infectious disease lab
8. Brenner Childrens Hospital named to NIH Pediatric Heart Network
9. Hospital admissions for asthma more likely for ethnic minorities in the UK
10. Society of Hospital Medicine selects John Wiley & Sons, Inc. to publish The Hospitalist Newsletter
11. Childrens Hospital at Vanderbilt ranked 8th in nation by Child magazine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... ... 2017 , ... On Saturday, October 21, the Health & Wellness Center at ... raise money for the American Heart Association Heart Walk. Teams of up to 10 ... to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
Breaking Medicine Technology:
Cached News: