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formation about dietary intake. HDL concentrations were lowest among subjects with two copies of the "T" allele (TT genotype) whose fat intake represented 30 percent or more of their diets, Ordovas says. Their average HDL was 1.15 millimoles per liter (mmol/L) [44 milligrams per deciliter]. People with the TT genotype and whose total fat intake was less than 30 percent of their total calories had average HDL of 1.35 mmol/L [52 mg/dL], which represents a 16 percent increase in HDL.

"When TT individuals consumed a low-fat diet, HDL concentrations increased. But there was a dose response to fat the more fat consumed, the lower the HDL," Ordovas says.

Conversely, people who had no copy of the "T" allele seemed to have the good genes. Their HDL level increased even as fat consumption increased and their HDL decreased when they ate a low-fat diet.

"The effect was seen only for animal fats. Consumption of fat from oils, polyunsaturated fatty acids, did not influence the relationship between the "T" allele and HDL," he says.

"This is another piece in the puzzle that helps us explain why some people will react to a dietary change while others do not. Our goal is to use this information to help us formulate dietary recommendations that are specifically tailored to different populations. For example, people with the TT genotype would greatly benefit from a severe restriction in animal fats."

But Ordovas cautioned that it's too soon to recommend widespread genetic testing to determine hepatic lipase gene type.

Co-authors are Dolores Corella, Ph.D.; Serkalem Demissie, Ph.D.; L. Adrienne Cupples, Ph.D.; Patrick Couture, M.D.; Oscar Coltell, M.Sc; Peter W.F. Wilson, M.D.; Ernst J. Schaefer, M.D.; and Katherine L. Tucker, Ph.D.
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Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
22-Oct-2002

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