Humans can regrow liver from bone marrow

ALEXANDRIA, VA., 6/19/00 -- Researchers have shown for the first time that the human liver can regenerate its tissue with a cell type from outside the organ -- and they present the first compelling evidence that those stem cells are human bone marrow.

"Furthermore, we're talking about significant amounts of functional liver tissue -- up to 40 percent in one case we studied," said Dr. Neil Theise, first author of the cover report for HEPATOLOGY's July issue. HEPATOLOGY is the monthly peer-reviewed journal of the American Association for the Study of Liver Diseases (AASLD). "The whole notion of a bone-marrow cell traveling around, becoming anything it wanted, is the first time I've had an idea that I couldn't see the limits of."

The discovery has implications for organ transplants, artificial livers, gene therapy and more, explained Theise, who is an associate professor of pathology at New York University School of Medicine.

Only in the last year have scientists in the field agreed that some animals, such as mice, can transform bone marrow into new liver tissue. Whether humans have liver stem cells at all has been a decades-old debate.

"The liver is an incredibly regenerative organ using its own cells," said Theise. "So some people have argued why invoke stem cells? A couple of studies have looked for them in humans but the data have never been definitive until now."

Theise and his team, which also includes investigators at Yale University School of Medicine and at Memorial-Sloan Kettering Cancer Center, started with a deceptively simple approach: only male cells carry the Y chromosome.

The researchers first examined samples of liver tissue from two women who had received bone-marrow transplants from male donors. They prepared the tissues and then stained them with chromosome-specific dye (Y chromosomes fluoresced as light green dots, X chromosomes as red). Between 5 and 20 percent of the women's liver cells (hepatocytes) and bile-duct cells (

Contact: Kirk Monroe
K-M Communications

Page: 1 2

Related medicine news :

1. University Of Pittsburgh Researchers Identify Immune System Process That Could Halt Progress Of Cirrhosis In Humans
2. New Research Points The Way To Restoring Noise-Induced Hearing Loss In Mammals, Including Humans
3. Cut Nerve Fibers Are Repaired In An Animal Model of Spinal Cord Injury; May Help Repair Nerve Damage In Humans
4. The Visible Humans: Coming Of Age
5. Post-transplant nerve regrowth better with young hearts, quick surgery
6. Yale researcher finds new clue to what blocks nerve fibers from regrowing following spinal cord injury or disease
7. Research offers hope of new treatments for liver damage
8. Success of liver transplantation may be most influenced by three risk factors
9. Alcohol relapse adversely affects 10-year liver transplant survival
10. Donor age has no affect on long-term liver transplant survival
11. NHS stop-smoking services are insufficient to deliver national smoking targets

Post Your Comments:

(Date:9/17/2019)... ... 17, 2019 , ... Drs. Charles Felts and Elizabeth Felts ... Chattanooga, TN for customized full mouth dental implants with TeethXpress® . TeethXpress ... providing a permanent tooth replacement solution for patients who struggle with the pain ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... announced that he has been certified by the American Academy of Facial Esthetics ... to correct a wide range of orofacial conditions such as tooth clenching and ...
(Date:9/17/2019)... ... September 17, 2019 , ... CORE Medical ... Dr. Yevgeniya (Jenny) Gartshteyn to their team of expert physicians. Dr. Gartshteyn completed ... the Clinical Appointment of Assistant Professor in Medicine for the Division of Hospitalist ...
(Date:9/12/2019)... ... September 12, 2019 , ... Donaldson Plastic Surgery & ... two recent and well-renowned listing publications, the Inc. 5000 and Columbus’s Fast 50, ... year. , Dr. Jeffrey Donaldson, CEO and owner of Donaldson Plastic Surgery ...
(Date:9/11/2019)... ... September 11, 2019 , ... Global Education Group (Global), a ... provider, is the official accreditor for PAINWeek, the largest US pain conference for ... as it has done for the past ten years. In addition, the Global ...
Breaking Medicine News(10 mins):
(Date:9/18/2019)... , ... September 18, 2019 , ... ... readmissions for patients receiving telehealth care via Henry Ford’s e-Home Care program. Achieving ... their average hospital readmission rate for the first six months of 2019 by ...
(Date:9/18/2019)... ... ... The interns of NJ Lenders Corp. recently spent their time giving back ... in Hackensack , where NJ Lenders donated $1,000 worth of school supplies for kids ... pizza party and handed out ice cream. , NJ Lenders is a part of ...
(Date:9/17/2019)... ... September 18, 2019 , ... Uniform Advantage (UA), a ... raise funds for Breast Cancer programs and services. , This year, more than 271,000 ... the disease. During the month of October 2019, Uniform Advantage will donate $5 for ...
Breaking Medicine Technology:
Cached News: