HOME >> MEDICINE >> NEWS
Humble Planaria worm offers ideal model for drug withdrawal research

Through the humble Planaria worm, Temple University researchers hope to discover what happens when drug abusers who take more than one drug-a common practice-go into withdrawal. Their work, which is funded by a new $450,000, three-year grant from the National Institutes of Health, is expected to lead to a better understanding of how withdrawal is influenced by poly-drug abuse and someday to the development of better treatment.

"People who abuse drugs tend to abuse many different drugs, yet much of the current research in the field focuses on single drug abuse," explained primary investigator, Robert Raffa, Ph.D., professor of pharmacology at Temple University School of Pharmacy.

Typically, abusers take several drugs together to multiply the pleasurable effects or manage the undesirable effects-for instance, using alcohol with cocaine. Because each type of drug affects the body differently, withdrawal is more complicated when more than one is involved. It would be impossible to conduct controlled scientific research on human subjects, so scientists have sought out alternatives.

As a study subject, the Planaria worm, a type of flatworm known for its regenerative powers, has several qualities attractive to scientists. First, it has such simple biochemistry and it readily absorbs any chemical in which it is soaked. This simplicity makes it a clean, easy-to-use model. But despite this simplicity, the Planaria worm has a brain and spinal cord, both key to studying the effects of drug abuse and withdrawal. Furthermore, Planaria have the same types of neurotransmitter systems as humans and thus respond to dopamine, opioids, cocaine and cannabinoids.

"Planaria offer a clean and uncomplicated model. We don't have to worry about potential interference from other organs or organ systems, as would be the case in other animal models," said Raffa. "Plus, Planaria display amazing behaviors. They can even learn."

Some might reme
'"/>

Contact: Eryn Jelesiewicz
dobeck@temple.edu
215-707-0730
Temple University
29-Nov-2004


Page: 1 2

Related medicine news :

1. UCSF study offers insight into human circadian rhythms
2. Research offers hope of new treatments for liver damage
3. Portable system offers dialysis patients liberating changes
4. New laparoscopic hysterectomy offers quicker recovery time than traditional surgery
5. UIC offers new weight loss surgery for obese teens
6. COX-2 product offers good and bad news in test tube strokes
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Research offers hope of new treatments for liver damage plague
9. Herpes virus offers new hope in curing cancer
10. Panel offers recommendations for monitoring adverse events from dietary supplements
11. Improved acute lymphoblastic leukemia treatment offers hope for eliminating irradiation

Post Your Comments:
(Date:7/31/2015)... , ... July 31, 2015 , ... ... important workshop at its new True North Conference Center. The medical community, social ... the Jacksonville community may be more aligned in the effort to better understand ...
(Date:7/31/2015)... ... 2015 , ... Ticket Down is a reliable source of authentic Hamilton ... and refreshing show on Broadway, look no further than Hamilton. This American musical is ... Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and New York Drama Critics’ ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... Brown’s live lecture on pharmaceutical negligence is now available online at ( ... received with a 94% approval rating from the nationwide audience. The ...
(Date:7/31/2015)... York (PRWEB) , ... July 31, 2015 , ... Transfinder, ... of 2015. , Total sales were up 16 percent year-over-year for the first six ... CEO Antonio Civitella said he expected Transfinder to beat last year’s record-revenue mark of ...
(Date:7/31/2015)... ... 31, 2015 , ... Mullin/Ashley Associates , a Mid-Atlantic ... Aster Awards national competition for a marketing communications campaign created for Atlantic ... in Coastal Maryland and Southern Delaware. , A Bronze Award was won for ...
Breaking Medicine News(10 mins):Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Transfinder Closes First Half of 2015 with Record Revenue 2Health News:Mullin/Ashley Associates Wins in the 2015 Aster Awards National Competition for Excellence in Medical Marketing 2
(Date:7/31/2015)... 2015  Physicians and payers alone do not ... Patients are better informed and getting increasingly involved ... This shift in power is reshaping the healthcare ... marketing. As part of this evolving ... important to educate, communicate and engage patients throughout ...
(Date:7/31/2015)... , July 31, 2015  In today,s ever-changing marketplace, ... are increasingly mobile, increasingly connected, and increasingly impatient with ... of customer interaction channels and tools is driving call ... media. According to research by benchmarking ... counter (OTC) segment in a call center study realize ...
(Date:7/31/2015)... , July 31, 2015  Seeger Weiss LLP is reporting ... issued a warning letter to C.R. Bard, the manufacturer of ... adequate strides to correct violations the agency found at two ... violations after the FDA cited them during Inspectional Observations that ... Bard,s Tempe, AZ , location and on ...
Breaking Medicine Technology:Consumers Forcing Pharmaceutical Industry to Shift its Marketing Focus from Products to Patients 2Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 3
Cached News: