HOME >> MEDICINE >> NEWS
Humble Planaria worm offers ideal model for drug withdrawal research

Through the humble Planaria worm, Temple University researchers hope to discover what happens when drug abusers who take more than one drug-a common practice-go into withdrawal. Their work, which is funded by a new $450,000, three-year grant from the National Institutes of Health, is expected to lead to a better understanding of how withdrawal is influenced by poly-drug abuse and someday to the development of better treatment.

"People who abuse drugs tend to abuse many different drugs, yet much of the current research in the field focuses on single drug abuse," explained primary investigator, Robert Raffa, Ph.D., professor of pharmacology at Temple University School of Pharmacy.

Typically, abusers take several drugs together to multiply the pleasurable effects or manage the undesirable effects-for instance, using alcohol with cocaine. Because each type of drug affects the body differently, withdrawal is more complicated when more than one is involved. It would be impossible to conduct controlled scientific research on human subjects, so scientists have sought out alternatives.

As a study subject, the Planaria worm, a type of flatworm known for its regenerative powers, has several qualities attractive to scientists. First, it has such simple biochemistry and it readily absorbs any chemical in which it is soaked. This simplicity makes it a clean, easy-to-use model. But despite this simplicity, the Planaria worm has a brain and spinal cord, both key to studying the effects of drug abuse and withdrawal. Furthermore, Planaria have the same types of neurotransmitter systems as humans and thus respond to dopamine, opioids, cocaine and cannabinoids.

"Planaria offer a clean and uncomplicated model. We don't have to worry about potential interference from other organs or organ systems, as would be the case in other animal models," said Raffa. "Plus, Planaria display amazing behaviors. They can even learn."

Some might reme
'"/>

Contact: Eryn Jelesiewicz
dobeck@temple.edu
215-707-0730
Temple University
29-Nov-2004


Page: 1 2

Related medicine news :

1. UCSF study offers insight into human circadian rhythms
2. Research offers hope of new treatments for liver damage
3. Portable system offers dialysis patients liberating changes
4. New laparoscopic hysterectomy offers quicker recovery time than traditional surgery
5. UIC offers new weight loss surgery for obese teens
6. COX-2 product offers good and bad news in test tube strokes
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Research offers hope of new treatments for liver damage plague
9. Herpes virus offers new hope in curing cancer
10. Panel offers recommendations for monitoring adverse events from dietary supplements
11. Improved acute lymphoblastic leukemia treatment offers hope for eliminating irradiation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology:
Cached News: