HOME >> MEDICINE >> NEWS
ILEX Oncology & LeukoSite report results from pivotal Phase II CAMPATH (R) trial; Results suggest new hope for refractory chronic lymphocytic leukemia

der to reduce the incidence and severity of infusion-related adverse events. Patients also received prophylactic anti-infective treatment to reduce the risk of opportunistic infections. The primary endpoint for this trial was overall response rate (complete and partial response), and the study objective was to demonstrate a major response rate of at least 20 percent. Response rate was assessed by an independent review panel in accordance with the National Cancer Institute's guidelines for the diagnosis and treatment of CLL.

Of 93 evaluable patients, 31 demonstrated an objective response to treatment, for an overall response rate of 33%. Two of these responses were complete (2%) and 29 were partial responses (31%). Another 55 (59%) patients had disease stabilization. Median survival time has not yet been reached at about 10 months after the last patient was enrolled.

The safety profile of CAMPATH was consistent with that seen in previous studies and was judged by the investigators to be acceptable in this group of endstage CLL patients.

Adverse effects associated with CAMPATH in this study of 93 patients were mostly mild to moderate infusion-related symptoms. Severe (grade 3 and 4) infusion-related symptoms included: fever (13%), rigors (11%), dyspnea (6%), and hypotension (1%). During the study patients developed severe (grade 3 and 4) thrombocytopenia (low platelet count, 51%) or neutropenia (low white blood cell count, 61%) that usually improved within two months post-therapy. Some patients entering the study with severe (grade 3 and 4) thrombocytopenia and neutropenia improved to grade 2 or better within two months post-therapy: thrombocytopenia -- 7 of 19 (37%) patients improved,neutropenia -- 11 of 17 (65%) patients improved.

No unexpected serious adverse events were reported. The incidence of serious infections was reported to be 20% on this trial. It should be noted that infection is a common complication and cause of death
'"/>

Contact: Deborah Sibley, ILEX Oncology
210-949-8287
Porter Novelli
12-Jun-1999


Page: 1 2 3 4 5

Related medicine news :

1. The 23rd Congress of the European Society for Therapeutic Radiology and Oncology (ESTRO)
2. Oncology Nursing Society honors Fox Chase Cancer Center nurse with Radiation Therapy Nursing Award
3. The Lancet Oncology (TLO)
4. The Lancet Oncology press release
5. The Lancet Oncology (TLO) and the Lancet Infectious Diseases (TLID)
6. The Lancet Oncology (TLO) June 2002
7. The Lancet Oncology (TLO) and The Lancet Infectious Diseases (TLID)
8. The Lancet Oncology and The Lancet Infectious Diseases
9. V. Craig Jordan Will Present Results Of Raloxifene Breast Cancer Study At American Society For Clinical Oncology Meeting
10. First UK cases of previously rare disease reported in gay men
11. Health care report cards may increase racial/ethnic disparities in bypass operations

Post Your Comments:
(Date:6/30/2015)... ... June 30, 2015 , ... Izenda is proud to acknowledge ... currently attending an accredited American educational institution through its scholarship program. , In ... healthcare, the environment, political campaigns, and a variety of other worldwide trends. Modern ...
(Date:6/30/2015)... ... June 30, 2015 , ... Scott Purdy, the spokesperson for ... Provider XO. Scott Purdy stated that the XO stands for eXtra Operability (XO) which ... the workflow processes of the Revenue Cycle. , Provider XO, based in Cleveland ...
(Date:6/29/2015)... (PRWEB) , ... June 30, 2015 , ... Sublime Beauty ... 50% Off offer. The oil, ideal for natural skincare and even culinary uses, ... easy way is something most people desire, and Oil Pulling can accomplish this. Oil ...
(Date:6/29/2015)... IL (PRWEB) , ... June 30, 2015 , ... Ticket ... show at Soldier Field over the 4th of July weekend. Concertgoers can add ... who have only recently caught on to their innovative sound, will not want to ...
(Date:6/29/2015)... Portland, OR (PRWEB) , ... June 29, 2015 , ... ... In America with James Earl Jones will offer a fresh perspective on ... Marc Williams . Williams is one of several thought leaders from around the sports ...
Breaking Medicine News(10 mins):Health News:Izenda Offers Embedded BI and Analytics Scholarship 2Health News:Izenda Offers Embedded BI and Analytics Scholarship 3Health News:Dephinitive Systems Is Getting a New Name 2Health News:New Product: Transform Wellness and Oral Health With This Ancient Ayurvedic Secret and Organic Product from Sublime Beauty NATURALS® 2Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Tickets Prices in Chicago at Soldier Field 2Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Tickets Prices in Chicago at Soldier Field 3Health News:Dr. Marc Williams Joins SCI and In America Sports Documentary 2Health News:Dr. Marc Williams Joins SCI and In America Sports Documentary 3
(Date:6/29/2015)... June 29, 2015  Arbor Solution has added ... The high-powered, multi-functional M2150 offers two ... Haswell Core i5-4402E 1.6 GHz processor and ... processing and computing performance. Integrated Intel® HD Graphics ... well suited for graphics-intense applications in operating rooms, ...
(Date:6/29/2015)... June 29, 2015 The Parenteral Drug Association ... Jersey Board of Professional Engineers and Land ... courses to professional engineers for continuing professional competency (CPC) ... the value and quality of PDA,s professional education offerings," ... courses and hands-on professional training at the Training and ...
(Date:6/29/2015)... , June 29, 2015   CSL Behring ... Alabama at Birmingham, United States , ... Leadership Award for original research in the ... monetary grants and/or product supply for investigational use to ... (Ig) therapy in the treatment of neurological disorders.  The ...
Breaking Medicine Technology:Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 2Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 3CSL Behring Announces the 2015 Interlaken Leadership Awards Recipient 2CSL Behring Announces the 2015 Interlaken Leadership Awards Recipient 3
Cached News: