HOME >> MEDICINE >> NEWS
Identification Of Brain Areas Could Help Eliminate Side Effects Of Pain Medication

HERSHEY, Pa. --- Researchers at Penn State's College of Medicine have identified a set of neurons in the brain that may contribute to some of the undesirable side effects of pain medication.

"Opioids such as morphine and morphine-like drugs still comprise the major tool for the clinical management of pain even though the drugs can have some very serious side effects," explains Ralph Lydic, Ph.D., professor of anesthesia. "This discovery means we have specifically targeted an area in the brain and a molecule that causes side effects from pain medication. We want to try and eliminate these side effects of pain medication by building another molecule to tag onto the opioid molecule. This way the opioid could block the pain, and this new molecule could prevent the side effects."

Specifically, Lydic and his team have discovered that this set of neurons may account for morphine's ability to decrease brain production of acetylcholine, a chemical known to be essential for normal rapid eye movement (REM) sleep. Often after surgery, patients have disrupted REM sleep because of pain medication. Lydic explains that REM sleep is the dreaming phase of sleep and is essential for feeling rested. Everyone has REM sleep each night, even if we do not remember our dreams. REM sleep occurs about every 90 minutes and lasts for about 20 minutes.

"We think this is a very exciting discovery. We are trying to identify specific cells in the brain where we know brain-produced chemicals have been altered because of the pain medication administered," explains Lydic. Other common side effects from pain medications can include respiratory depression, itching, constipation, urinary retention and addiction.

The Penn State researcher says the team is trying to understand brain mechanisms that regulate consciousness as they try to improve pain control and anesthesia safety. He adds, "The discovery of anesthesia is onl
'"/>

Contact: Leilyn Perri
lperri@psghs.edu
717-531-8604
Penn State
8-May-1998


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
3. Brain imaging reveals secrets of love, fear and betrayal
4. Brain imaging studies investigate pain reduction by hypnosis
5. Brain tumor with dismal prognosis in infants can be cured in older children
6. Brain-scanning technologies need standards, according to Stanford researcher
7. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
8. Brain synapse formation linked to proteins, Stanford study finds
9. Brain tumor treatment can vary greatly, according to new JAMA study
10. Brain region identified that controls collecting behavior
11. Brain imaging reveals new language circuits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... The American ... held Wednesday, April 7, to Saturday, April 10, 2021, at Wynn Las Vegas. ... is a national trade show for non-invasive medical aesthetic practices that brings together ...
(Date:9/3/2020)... ... 2020 , ... International Dark-Sky Association (IDA) recently bestowed the ... This advanced LED wireless dimming controller, along with the previously IDA approved Dimulator, ... against light pollution. Leo Smith, the Northeast Regional Director for IDA says “We ...
(Date:9/1/2020)... ... September 01, 2020 , ... Board certified plastic ... While the office will be the first to bear her name, Dr. Saber ... (Brazilian butt lift), as well as rhinoplasty, facial rejuvenation, and many more in ...
(Date:9/1/2020)... ... September 01, 2020 , ... Feeding Matters , the first organization in ... Disorder (PFD), is pleased to announce that the U.S. Centers for Disease Control and ... in the next edition of the U.S. International Classification of Diseases (ICD ) ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... fellowship training in aesthetic surgery of the face, breast, and body. In 2018, ... female-owned premier boutique plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... 2020 , ... U.S. Dermatology Partners is excited to welcome Board-Certified ... at Bethesda Dermatopathology Lab. , Jonathan Lee, MD grew up in the ... He went on to receive his M.D. with Honors from Harvard Medical School and ...
(Date:9/1/2020)... ... , ... Breast and ovarian cancers are common diseases that affect many women. ... (about 7,500 women per year) and 10% of ovarian cancers (about 2,000 women per ... are detectable in the Women’s Excellence Genetic Testing Program. , Dr. Jonathan Zaidan, MD, ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... guide, has named Cloudticity a Gold winner in the 15th Annual 2020 Network ... recogniti o ns from Network Products Guide honoring achievements of world’s ...
Breaking Medicine Technology:
Cached News: