HOME >> MEDICINE >> NEWS
IgG treatment during pregnancy reduces severity of rare, recurring liver condition in newborns

CHICAGO --- Treatment with high-dose immunoglobulin G (IgG) during pregnancy lessens the severity of hemochromatosis (NH), a rare, devastating gestational disease with abnormal iron accumulation in the liver and severe liver injury that almost always results in fetal death or acute liver failure in newborns.

In an article in the Nov. 6 issue of The Lancet, researchers Peter F. Whitington, M.D., and Judith U. Hibbard, M.D., described the effectiveness of treating mothers with IgG in reducing liver injury in babies with recurrent NH.

Whitington, a noted authority on liver disease, is professor of pediatrics at Northwestern University Feinberg School of Medicine, Children's Memorial Hospital. Hibbard is professor of maternal-fetal medicine, University of Illinois Chicago and held a similar position at the Pritzker School of Medicine, University of Chicago, during the course of the study.

One of the most devastating aspects of NH to affected families is that after a woman has had one baby with the disorder, her risk for recurrence of NH in another child is 80 percent. A woman may have unaffected children before having the first one with NH. After that, most or all pregnancies end with fetal death or a child born with NH.

Currently, there is no test to determine if a pregnancy will be affected, and there is no effective approach to prenatal diagnosis of NH. The best advice available to date for such women is to avoid pregnancy.

Until now, the cause of NH has been unknown. Whitington hypothesized that it is an alloimmune disease based on its unusual pattern of recurrence, which is similar to the known alloimmune diseases hydrops fetalis due to Rh incompatibility and neonatal alloimmune thrombocytopenia.

Treatment with IgG has been found effective in the treatment of these alloimmune blood disorders, so Whitington proposed its use in NH.

The positive results of the current study provide support for the th
'"/>

Contact: Elizabeth Crown or Kathleen Ellis
e-crown@northwestern.edu
312-503-8928
Northwestern University
9-Nov-2004


Page: 1 2

Related medicine news :

1. Hormonal treatment improves survival in high-risk prostate cancer patients
2. Chronic pain treatments more effective when taken together, new study shows
3. Brain activity prior to treatment flags vulnerability to antidepressant side effects
4. Cultural and social factors influence prostate cancer treatment
5. Research offers hope of new treatments for liver damage
6. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
7. Stanford patient is first to test new treatment for peripheral arterial disease
8. Scientist works on innovative treatments for brain tumors
9. Blacks less likely to get expensive, newer heart treatments
10. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
11. Study examines lessons learned at Africas first public antiretroviral treatment clinic

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... When it came time to blow out his candles on ... later, the Pediatric Heart Transplant team at Joe DiMaggio Children’s Hospital surprised his ... the hospital’s 30th heart transplant recipient. , “He was playing at home, when we ...
(Date:12/7/2016)... ... December 07, 2016 , ... One of two inventors ... the securement tape is painful for her. "This is why the co-inventor and I ... she said. , They then created a prototype of the patent-pending AV-AIR, a device ...
(Date:12/7/2016)... ... December 07, 2016 , ... The ... its fully redesigned website, which launched October 17, 2016, features comprehensive information regarding ... and easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology treatments ...
(Date:12/7/2016)... ... December 07, 2016 , ... The medical profession is well aware that heart ... major study analyzing heart attacks among 138,602 people recorded a 35% higher number of ... would all agree of course–no time of year is a good time for a ...
(Date:12/7/2016)... ... 07, 2016 , ... “The Road To Restoration”: an informative and enlightening ... hour a week showing of hands. “The Road To Restoration” is the creation of ... familiar with the brass ring that you could reach out for, and grab, on ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... -- Two new disaster drones delivered telemedical packages to ... event Tuesday at John Bell Airport in ... audience including Mississippi Governor ... Law Enforcement Agencies, and the United Nations. ... Rescue Operations), was developed by Italo Subbarao , ...
(Date:12/6/2016)... With opioids commonly used for pain management for workplace ... that has led to nationwide fatalities. The synthetic opioid ... than heroin or morphine, resulting in likelihood of addiction, abuse or ... , , ... operations, Behavioral Health for HMC HealthWorks, explained the opioid drug is ...
(Date:12/6/2016)... SAN DIEGO , Dec. 6, 2016 /PRNewswire/ ... ), a clinical-stage biopharmaceutical company focused on the ... disorders, today announced that the U.S. Food and ... to VK0214 for the treatment of X-linked adrenoleukodystrophy ... receptor beta (TRß) agonist that selectively regulates the ...
Breaking Medicine Technology:
Cached News: