HOME >> MEDICINE >> NEWS
IgG treatment during pregnancy reduces severity of rare, recurring liver condition in newborns

CHICAGO --- Treatment with high-dose immunoglobulin G (IgG) during pregnancy lessens the severity of hemochromatosis (NH), a rare, devastating gestational disease with abnormal iron accumulation in the liver and severe liver injury that almost always results in fetal death or acute liver failure in newborns.

In an article in the Nov. 6 issue of The Lancet, researchers Peter F. Whitington, M.D., and Judith U. Hibbard, M.D., described the effectiveness of treating mothers with IgG in reducing liver injury in babies with recurrent NH.

Whitington, a noted authority on liver disease, is professor of pediatrics at Northwestern University Feinberg School of Medicine, Children's Memorial Hospital. Hibbard is professor of maternal-fetal medicine, University of Illinois Chicago and held a similar position at the Pritzker School of Medicine, University of Chicago, during the course of the study.

One of the most devastating aspects of NH to affected families is that after a woman has had one baby with the disorder, her risk for recurrence of NH in another child is 80 percent. A woman may have unaffected children before having the first one with NH. After that, most or all pregnancies end with fetal death or a child born with NH.

Currently, there is no test to determine if a pregnancy will be affected, and there is no effective approach to prenatal diagnosis of NH. The best advice available to date for such women is to avoid pregnancy.

Until now, the cause of NH has been unknown. Whitington hypothesized that it is an alloimmune disease based on its unusual pattern of recurrence, which is similar to the known alloimmune diseases hydrops fetalis due to Rh incompatibility and neonatal alloimmune thrombocytopenia.

Treatment with IgG has been found effective in the treatment of these alloimmune blood disorders, so Whitington proposed its use in NH.

The positive results of the current study provide support for the th
'"/>

Contact: Elizabeth Crown or Kathleen Ellis
e-crown@northwestern.edu
312-503-8928
Northwestern University
9-Nov-2004


Page: 1 2

Related medicine news :

1. Hormonal treatment improves survival in high-risk prostate cancer patients
2. Chronic pain treatments more effective when taken together, new study shows
3. Brain activity prior to treatment flags vulnerability to antidepressant side effects
4. Cultural and social factors influence prostate cancer treatment
5. Research offers hope of new treatments for liver damage
6. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
7. Stanford patient is first to test new treatment for peripheral arterial disease
8. Scientist works on innovative treatments for brain tumors
9. Blacks less likely to get expensive, newer heart treatments
10. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
11. Study examines lessons learned at Africas first public antiretroviral treatment clinic

Post Your Comments:
(Date:4/25/2015)... 2015 The Hon. Ellen Tauscher, Independent ... the following statement following the deadly earthquake in Nepal: ... resulting in the deaths of more than 1,000 people. ... across Nepal, Bangladesh, India and other parts of South ... to the people of Nepal and the families of ...
(Date:4/25/2015)... York, NY (PRWEB) April 25, 2015 By ... technology and data for the enterprise relying on their judgement ... running smoothly. But according to an article published ... can many times actually be doing a disservice to their ... i’s are dotted and t’s are crossed when it comes ...
(Date:4/25/2015)... Parker and Sons projects growth in 2015. The demand ... alongside the growing economy. As a result, Parker and Sons ... help account for the rising need for heating, cooling, and ... we are enthusiastic about. It means growth for us, and ... and Sons. , Indeed, Parker and Sons has been contributing ...
(Date:4/25/2015)... Minnesota (PRWEB) April 25, 2015 For thirteen ... the premier income protection education event in the nation! This ... with The Plus Group, US to take DI Day on ... , George G. Davidson, CLU, ChFC, RHU, DIA, CLTC, Chief ... Cities DI Day reflects on the change by stating, "The ...
(Date:4/24/2015)... As the nation recognizes the Month ... of these young men and women, the “Alaska – ... their Families” presents a special training session on Adverse ... a better understanding of the effect of childhood trauma ... – civilian and military – who provide services and ...
Breaking Medicine News(10 mins):Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 2Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 4Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 5Health News:Parker and Sons Plans to Expand in 2015 2Health News:Secura Consultants Takes DI Day On The Road 2Health News:Coalition Presents Resiliency Training to Raise Awareness during Month of the Military Child (#MOTMC2015) 2
(Date:4/24/2015)... Ga. , April 24, 2015 ... researchers, paper, that such was not the product of reliable ... form a reliable basis for allegations of adulteration. ... position on a false premise, or misguided hope, ... fact, these studies are contradicted by multiple other ...
(Date:4/24/2015)... , April 24, 2015  Blueprint Medicines today ... selective and potent inhibitor of fibroblast growth factor ... models of hepatocellular carcinoma (HCC) that are dependent ... BLU-554 induced complete tumor regression in a subset ... ligand at the highest dose levels. These data ...
(Date:4/23/2015)... , April 23, 2015 /CNW/ - Health Canada ... ibuprofen products to update the safety information regarding the ... and stroke) when these products are used at high ... with dose and duration of use. Ibuprofen ... and fever relief, and to reduce inflammation. The majority ...
Breaking Medicine Technology:Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 2Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 3Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 4Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 5Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 6Blueprint Medicines Presents New Preclinical Data Demonstrating Its Drug Candidate BLU-554 Induces Significant Tumor Regression in Models of Hepatocellular Carcinoma 2Blueprint Medicines Presents New Preclinical Data Demonstrating Its Drug Candidate BLU-554 Induces Significant Tumor Regression in Models of Hepatocellular Carcinoma 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 2Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 4
Cached News: