Imatinib (Gleevec) has activity in AIDS-related Kaposi's sarcoma

Alexandria, VA--A new clinical study has shown that imatinib mesylate (Gleevec) has activity in AIDS-related Kaposi's sarcoma (KS). Imatinib inhibits important pathways that spur cancer growth, resulting in the regression of KS tumors within 4 weeks in some patients. The study will be published November 30 in the Journal of Clinical Oncology (JCO).

"Imatinib is a targeted therapy originally shown to be effective in treating chronic myelogenous leukemia and gastrointestinal stromal tumors. This study and others are showing that the drug is also active in other cancers that express some of the same proteins," said Henry B. Koon, MD, Instructor of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School in Boston, and lead author of the study. "Studies like this one represent an exciting time in oncology, when our understanding of the development of diseases like KS coincide with the availability of effective treatments. Further research on imatinib in KS patients will be needed to determine appropriate dosing schedules."

Kaposi's sarcoma is an AIDS-defining illness characterized by soft purplish lesions on the skin, mucous membranes, and internal organs. Although the incidence of KS has declined dramatically in the developed world since the advent of highly active antiretroviral therapies (HAART), it remains a significant cause of morbidity and mortality for AIDS patients in the United States and a major cause of mortality in the third world, given the limited number of effective treatments for KS.

Researchers examined the response of Kaposi's sarcoma to imatinib, a drug known to inhibit the PDGF-R and/or c-kit pathways that are responsible for the growth of other cancers, such as chronic myelogenous leukemia, gastrointestinal stromal tumors (GIST), and bone sarcomas of the head and neck. Given that PDGF-R and c-kit also play a role in the development of KS, researchers theorized that imatinib may be an effective strategy

Contact: Danielle Potuto
American Society of Clinical Oncology

Page: 1 2

Related medicine news :

1. Imatinib shows early promise against Ewings sarcoma
2. Brain activity prior to treatment flags vulnerability to antidepressant side effects
3. Physical activity linked to protection from Parkinsons disease
4. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
5. Abnormal brain activity during the observation of others actions
6. Increased physical activity not linked to ALS risk
7. Maintaining physical activity linked to less cognitive decline in older men
8. Daily social/physical activity improves sleep and cognition in the elderly
9. Celecoxib shows surprising activity against estrogen receptors
10. Jefferson scientists find way to see breast cancer activity from outside the body
11. Brain activity reflects complexity of responses to other-race faces

Post Your Comments:
TAG: Imatinib Gleevec has activity AIDS related Kaposi sarcoma

(Date:10/9/2015)... ... October 09, 2015 , ... ... individuals from all walks of life to save money on the high cost ... $25 per month per medication, individuals and families can receive their medications delivered ...
(Date:10/9/2015)... ... 2015 , ... Ryan Fox, the founder and CEO of ... says the latest figures on the state’s sales of legalized marijuana acknowledge that ... , Last month, according to the website AllGov.com , Colorado's Department ...
(Date:10/9/2015)... ... ... was featured on NewsWatch as part of its monthly Tech Report, which features the ... special reporter for NewsWatch, conducted the review and shared with viewers how this security ... it’s more important than ever to keep homes and dorms safe and protected. That ...
(Date:10/9/2015)... , ... October 09, 2015 , ... Dignity Health named ... General Hospital Emergency Room – Chandler–McQueen opening later this month. The new ... this year in the West Valley. , “Dr. Morro is an excellent leader ...
(Date:10/9/2015)... ... 09, 2015 , ... Yisrayl Hawkins, Pastor at The House of Yahweh in ... health care back to the beginning, literally, starting in the book of Genesis. ... if only biblical laws were being taught. The letter addresses the many types ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... , Oct. 9, 2015 Ansun BioPharma ... Disease Society of America ) regarding the compassionate use ... patient on a respirator who was co-infected with influenza ... five-day course of therapy, O 2 requirement was ... patient was able to go off the respirator on ...
(Date:10/9/2015)... ,JCA-Mauvernay Award 2015, se ha otorgado a los doctores ... Takita    --> El ,JCA-Mauvernay Award 2015, ... y Junko Takita    --> ... los doctores Yutaka Kondo y ... con sede enSuiza, presentará el ,JCA-Mauvernay Award, el 10 de octubre a los ...
(Date:10/8/2015)... ® ) in adult ... NOCT study also assessed the compliance, safety, patient ... ® ) in adult patients undergoing screening, surveillance ... the compliance, safety, patient acceptability and tolerability of ... top line results for its phase III study, ...
Breaking Medicine Technology:
Cached News: