HOME >> MEDICINE >> NEWS
Immune system protein may be critical in kidney disorders and other diseases

St. Louis, Oct. 8, 1999--Evolution has an uncanny way of reusing good blueprints, as researchers recently were reminded when they discovered that a protein involved in immune-cell interactions may be important for kidney function.

Andrey S. Shaw, M.D., principal investigator of the research on the CD2-associated protein, says, "Defects in CD2AP may play a critical role in some kidney diseases."

The research is published in today's issue of Science. The first authors of the paper are postdoctoral fellow Neng-Yao Shih, Ph.D., and research associate Jun Li, who both work in Shaw's laboratory at Washington University School of Medicine in St. Louis.

Shaw, associate professor of pathology, led a team of researchers who studied the protein. His group originally cloned the gene as a molecule important for T cell function. The researchers were surprised to find that CD2AP is also specifically expressed in the kidney glomerulus, which filters toxins and other substances from the blood.

The researchers found that mice lacking CD2AP had defective glomeruli and died of renal failure. When they analyzed these mice, they found that CD2AP was expressed in the kidney, mainly in a cell known as a glomerular epithelial cell. The glomerular epithelial cell has a complex shape with foot-like extensions that wrap around capillaries of the glomerulus, forming spaces for the flow of blood filtrate that are called slit diaphragms. In the mice lacking CD2AP, the epithelial cells were damaged and the slit diaphragms were lost.

The mice, developed by Shih and Li, died of kidney failure by the time they were 6 weeks old. The researchers, including co-author Jeffrey H. Miner, Ph.D., assistant professor of medicine and of cell biology and physiology, found progressive damage to the foot-like extensions as early as one week after the mice were born.

How could missing CD2AP have such a dramatic effect on the kidneys? To address this question, Shaw re
'"/>

Contact: Barbra Rodriguez
rodrigub@medicine.wustl.edu
314-286-0122
Washington University School of Medicine
8-Oct-1999


Page: 1 2

Related medicine news :

1. Immune therapy appears to reduce risk of second attack of multiple sclerosis symptoms
2. Immune cells may play important role in progression of type 1 diabetes, Joslin researchers find
3. Immune memory from smallpox vaccination lasts more 50 years, according to Emory research
4. Immune alarm system can both amplify and silence alerts, scientists find
5. Immune response to Alzheimer diseaserelated protein changes as we age
6. Immune system supressor drug found effective in treating precancerous blood disorder
7. Immune system in hamsters bolstered during winter, especially in times of stress, study finds
8. Immune system cells surprisingly high in HIV-infected adolescents, says researcher at the Childrens Hospital of Philadelphia
9. Immune system responds greater to uncontrollable stresses
10. Immune system rebounds for some children with AIDS, finds UF study
11. Immunex Files Supplemental NDA for NOVANTRONE

Post Your Comments:
(Date:7/31/2014)... Dublin, Ohio (PRWEB) July 31, 2014 ... solutions for health care, announces the release of a “Twelve ... web seminar for hospitals that are evaluating Health Information Service ... 2. Hospitals that utilize MEDITECH and Epic electronic health ... order to exchange transitions of care using the Direct protocol. ...
(Date:7/31/2014)... 2014 A cancer diagnosis is crushing and ... and resume normal lives. This is particularly true of prostate ... one in seven American men but which when detected early, ... rate of nearly 100% and a ten-year survival rate of ... diagnosed with the disease do not die from it. There ...
(Date:7/31/2014)... its latest blog post, Best Drug Rehabilitation , which ... during a stay in rehab can make a big difference ... on nine secrets that addicts don’t want others to know. ... an addict from a mile away, and totally understand what’s ... Per Wickstrom . “However, take it from me: spotting ...
(Date:7/31/2014)... July 31, 2014 In its latest blog ... and believes that having family close by during a stay ... not the process is successful, is looking at 10 tips ... , “Addiction recovery is a lifelong process, and one ... be committed to without compromise,” commented Best Drug Rehabilitation’s CEO ...
(Date:7/31/2014)... Oregon (PRWEB) July 31, 2014 ... properties and digestibility, erythritol has long been used ... such as stevia and monk fruit. However consistent, ... In an effort to meet food and beverage ... sourcing, Steviva Ingredients has launched GMO-free ErysweetTM Erythritol. ...
Breaking Medicine News(10 mins):Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 2Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 4Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 2Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 3Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 4Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 3Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:Steviva Ingredients Launches Erysweet Erythritol 2
(Date:7/30/2014)... Calif. , July 30, 2014  El Camino ... improve patient care, is utilizing the Leaf Patient Monitoring ... the position and movement of patients susceptible to bed ... a six month-long, 138-patient study of the system, which ... turn protocols. Turning patients regularly is the one of ...
(Date:7/30/2014)... July 30, 2014  InnoPharma, Inc. today announced the ... generic equivalent of Zyprexa® injection), in Canada.  Olanzapine is ... behaviors in patients with schizophrenia or bipolar I mania. ... drug, InnoPharma has entered into an agreement with Sandoz ... will make, use, sell, market and distribute Olanzapine Injection ...
(Date:7/30/2014)... July 30, 2014 Cynosure, Inc. (NASDAQ: ... aesthetic treatments for non-invasive and minimally invasive applications, today announced ... Chief Operating Officer and Chief Financial Officer Timothy W. ... 2014.  Baker, 53, will continue to serve as CFO and ... , who remains Chairman and Chief Executive Officer. ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3InnoPharma Announces Launch of Olanzapine for Injection, 10mg/vial in Canada 2Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2
Cached News: