HOME >> MEDICINE >> NEWS
Immune system protein may be critical in kidney disorders and other diseases

St. Louis, Oct. 8, 1999--Evolution has an uncanny way of reusing good blueprints, as researchers recently were reminded when they discovered that a protein involved in immune-cell interactions may be important for kidney function.

Andrey S. Shaw, M.D., principal investigator of the research on the CD2-associated protein, says, "Defects in CD2AP may play a critical role in some kidney diseases."

The research is published in today's issue of Science. The first authors of the paper are postdoctoral fellow Neng-Yao Shih, Ph.D., and research associate Jun Li, who both work in Shaw's laboratory at Washington University School of Medicine in St. Louis.

Shaw, associate professor of pathology, led a team of researchers who studied the protein. His group originally cloned the gene as a molecule important for T cell function. The researchers were surprised to find that CD2AP is also specifically expressed in the kidney glomerulus, which filters toxins and other substances from the blood.

The researchers found that mice lacking CD2AP had defective glomeruli and died of renal failure. When they analyzed these mice, they found that CD2AP was expressed in the kidney, mainly in a cell known as a glomerular epithelial cell. The glomerular epithelial cell has a complex shape with foot-like extensions that wrap around capillaries of the glomerulus, forming spaces for the flow of blood filtrate that are called slit diaphragms. In the mice lacking CD2AP, the epithelial cells were damaged and the slit diaphragms were lost.

The mice, developed by Shih and Li, died of kidney failure by the time they were 6 weeks old. The researchers, including co-author Jeffrey H. Miner, Ph.D., assistant professor of medicine and of cell biology and physiology, found progressive damage to the foot-like extensions as early as one week after the mice were born.

How could missing CD2AP have such a dramatic effect on the kidneys? To address this question, Shaw re
'"/>

Contact: Barbra Rodriguez
rodrigub@medicine.wustl.edu
314-286-0122
Washington University School of Medicine
8-Oct-1999


Page: 1 2

Related medicine news :

1. Immune therapy appears to reduce risk of second attack of multiple sclerosis symptoms
2. Immune cells may play important role in progression of type 1 diabetes, Joslin researchers find
3. Immune memory from smallpox vaccination lasts more 50 years, according to Emory research
4. Immune alarm system can both amplify and silence alerts, scientists find
5. Immune response to Alzheimer diseaserelated protein changes as we age
6. Immune system supressor drug found effective in treating precancerous blood disorder
7. Immune system in hamsters bolstered during winter, especially in times of stress, study finds
8. Immune system cells surprisingly high in HIV-infected adolescents, says researcher at the Childrens Hospital of Philadelphia
9. Immune system responds greater to uncontrollable stresses
10. Immune system rebounds for some children with AIDS, finds UF study
11. Immunex Files Supplemental NDA for NOVANTRONE

Post Your Comments:
(Date:3/3/2015)... March 03, 2015 The combinatorial, ... predict antidepressant treatment outcomes for patients with depression, ... any of the individual genes that comprise the ... from the Mayo Clinic and Assurex Health, and ... , The proprietary technology of the GeneSight Psychotropic ...
(Date:3/3/2015)... The Calistoga Chamber of Commerce announces a brand new ... Friday, March 27, through Sunday, March 29, 2015. The weekend-long ... restaurant and bar crawl, lodging and spa specials, yoga and ... and older. , A variety of lodging and spa properties ... by offering Mudder of All Weekends packages featuring special room ...
(Date:3/3/2015)... March 03, 2015 Introducing 3D ... Labs is a recognized leader in Digital Dentistry. ... produces the best dental replicas, leaving no room ... digital scanning, dental professionals are able to significantly ... printers consistently deliver remarkable quality while reducing labor ...
(Date:3/3/2015)... CA (PRWEB) March 03, 2015 ... and collaboration, announces Mirroring360 is now available for Epson® ... download from the Moverio Apps Market , iPod, ... mobile device experience to the Epson Moverio smart glasses ... usage models. , The Epson smart glasses ...
(Date:3/3/2015)... Retrofit , the comprehensive weight ... corporations, today announces the appointment of its new chief ... Mary Pigatti has recruited technology, healthcare and ... for the fast-growing company, which was recently named one ... 2015. , “Retrofit is thrilled to announce this new ...
Breaking Medicine News(10 mins):Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 4Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 6Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 3Health News:Iverson Dental Labs Introduces 3D Digital Dental Technology for Superior Products 2Health News:Iverson Dental Labs Introduces 3D Digital Dental Technology for Superior Products 3Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 2Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 3Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 2Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 3Health News:Retrofit Signals Growth: Corporate Weight Management Company Announces Talent Acquisitions 4
(Date:3/3/2015)... COLORADO SPRINGS, Colo. , March 3, 2015 /PRNewswire/ ... in the development of cannabis-based medicine, today announced two ... preparation for its multiple global product launches, and CEO ... views in the Chicago HR Examiner. In ... C. Waits about leading a company in an ...
(Date:3/3/2015)... Mar. 03, 2015 Research and Markets ... PharmaBiotech,s new report "Cardiovascular Drug Delivery - Technologies, ... Drug delivery to the cardiovascular system is ... anatomy and physiology of the vascular system; it supplies ... Drugs can be introduced into the vascular system for ...
(Date:3/3/2015)... YORK , March 3, 2015  Delcath ... specialty pharmaceutical and medical device company focused on ... primary and metastatic liver cancers, announces that the ... completed enrollment in 2009, have been submitted for ... clinical study utilized Melphalan Hydrochloride for Injection for ...
Breaking Medicine Technology:CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 2CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 3CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 4CBIS Momentum Continues: Company Opens Call Center In Preparation For New Product Releases & CEO Shares His 'Impressive And Insightful' Views With Columnist 5Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 2Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 3Delcath Announces Submission Of Phase 3 Trial Results For Publication In A Leading Peer-Reviewed Medical Journal 2Delcath Announces Submission Of Phase 3 Trial Results For Publication In A Leading Peer-Reviewed Medical Journal 3Delcath Announces Submission Of Phase 3 Trial Results For Publication In A Leading Peer-Reviewed Medical Journal 4
Cached News: