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Improved Ritalin Offers Smaller Doses And Fewer Side Effects

ight hand of Ritalin. The most common reported side effects of Ritalin are nervousness and insomnia.

Since Ritalin works at the same receptor in the brain as cocaine, Winkler's group is examining their new analogues in cloned cell lines to see if they can be used to block the uptake of cocaine in that area of the brain, without inhibiting the normal flow of dopamine, an important chemical neurotransmitter vital to the proper functioning of the central nervous system.

"We have just developed the most potent compounds known in the literature, which have a ten to one selectivity for inhibiting cocaine without interfering with dopamine," claims Winkler. "And, we have just started our studies," he adds.

While synthesis of the improved form of Ritalin for treatment of ADHD is ready for commercial scale-up, Winkler says, the anticocaine portion of the research is still in the early stages and has yet to be studied in animals and humans.


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Contact: Charmayne Marsh
y_marsh@acs.org
202-872-4445
American Chemical Society
23-Mar-1999


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