HOME >> MEDICINE >> NEWS
Improved acute lymphoblastic leukemia treatment offers hope for eliminating irradiation

Improved risk classification for patients with acute lymphoblastic leukemia (ALL), coupled with more intensive intrathecal chemotherapy for high risk patients and the use of a drug called dexamethasone, could one day permit physicians to omit irradiation as a part of routine treatment. These findings emerged from a clinical trial conducted by investigators at St. Jude Children's Research Hospital. For intrathecal chemotherapy the drugs are injected into the cerebrospinal fluid-filled spaces between the thin membranes covering the spinal cord.

The researchers base their conclusion on results of a study of ALL treatment at St. Jude called Total Therapy Study XIIIB, which are reported in the Nov. 1 issue of the journal Blood. The overall five-year event-free survival rate of the children in Study XIIIB was just above 80 percent, and the overall survival rate was about 86 percent, according to the researchers. Event-free survival means that patients do not experience a recurrence of symptoms or other complications related to the disease or its treatment.

The researchers substituted dexamethasone for the routinely used drug prednisone to achieve greater antileukemic effects in both the central nervous system (brain and spinal cord) and the blood stream. The investigators also used more precise criteria to identify those children who should get more intensive intrathecal and intravenous therapy because they were at high risk for treatment failure.

Success of the modified chemotherapy treatment of XIIIB is significant because it established the importance of intensifying intrathecal chemotherapy early in treatment, and also set the stage for the current St. Jude clinical trial that omits the use of cranial irradiation in all patients, according to Ching-Hon Pui, M.D., director of the St. Jude Leukemia/Lymphoma Division, and American Cancer Society F.M. Kirby Clinical Research Professor. Pui is the first author of the Blood article.

"The ability to
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
1-Nov-2004


Page: 1 2 3

Related medicine news :

1. Improved mood tied to better language ability
2. Improved procurement could more than double availability of life-saving transplant organs
3. Improved molecular beacons show promise for cancer detection, rapid viral diagnosis
4. Patient Satisfaction And Decision Making Quality Greatly Improved During Improved Medical Consultations, UCSF Researchers Report
5. Improved Fitness Lowers Mortality Risk Of Male Heart-Attack Survivors
6. Improved Ritalin Offers Smaller Doses And Fewer Side Effects
7. Improved Medications Can Nip Allergy Season In The Bud
8. Secondary Prevention Of Heart Disease Should Be Improved
9. Cardiac Arrests Outside Hospital - Survival Could Be Improved By Better Public Awareness Of Symptoms
10. Combined Therapy Improved Care Of Patients With Type 2 Diabetes Proper Use Of New Oral Medications Evaluated
11. Dedicated hospital stroke centers improve quality of acute care

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/15/2019)... (PRWEB) , ... October 15, 2019 , ... In 2019, ... began to shut down in late 2018 . Students who started in July ... time, it seemed as if these students would have to start over. Then the ...
(Date:10/11/2019)... ... October 11, 2019 , ... Only 6% of orthopedic surgeons in the country ... as a female physician leading the sports medicine program. These four work with a ... succeed in traditionally male-oriented fields. , Orthopedic medicine deals with the correction ...
(Date:10/10/2019)... ... October 10, 2019 , ... AltMed Florida , one of the fastest ... announced the grand opening of its second MÜV™ Medical Cannabis Dispensary on the First ... 4 in Jacksonville Beach. , Located at Beach Plaza Shopping Center at the corner ...
(Date:10/10/2019)... ... October 10, 2019 , ... In ... 21 was excited to hear the significant results of an independent study presented ... of Nitrosigine®. The clinical study poster entitled “The Acute Effects of Citrulline Malate ...
(Date:10/8/2019)... ... October 08, 2019 , ... SoCal Adolescent Wellness announces ... to announce the expansion of our services to better serve the families in Orange ... this last year to see the extraordinary impact this pre-intervention program has on the ...
Breaking Medicine News(10 mins):
(Date:10/11/2019)... ... October 11, 2019 , ... ... 13, 2019, to recognize the dedication, compassion and quality patient outcomes achieved by ... providing a unique and vital link between patients, providers and payers to improve ...
(Date:10/10/2019)... LOS ANGELES (PRWEB) , ... October 10, 2019 ... ... as a prolific producer of research in the field of reproductive medicine, with ... Expo, the premier conference for reproductive experts, slated for October 12-16, 2019, in ...
(Date:10/10/2019)... ... 10, 2019 , ... This World Sight Day, we honor the importance of ... pleased to announce their recent interview with Brand Manager Lynn Hicks and Accessibility Leader ... all abilities identify and choose effective hair care products. , Herbal Essences ...
Breaking Medicine Technology:
Cached News: