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Improved acute lymphoblastic leukemia treatment offers hope for eliminating irradiation

ts considered at high risk for relapse were those who had T-cell ALL and especially high white blood cell counts, or patients with evidence of leukemia in the central nervous systems.

The overall event-free-survival rate of low-risk patients in Study XIIIB was about 89 percent, while the rate for high-risk patients was about 74 percent. Only 1 percent of patients experienced a relapse where leukemic cells appeared in their central nervous systems.

"Our ultimate goal is to cure all patients with ALL," said William E. Evans, Pharm.D., St. Jude hospital director and a senior author of the paper. "To do this, we will have to continue to improve our ability to target therapy more effectively in patients with genetic abnormalities that identify them as being at high risk for treatment failure. For example, we are already testing a new treatment for high-risk patients with ALL carrying the Philadelphia chromosome."


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Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
1-Nov-2004


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