"More than 60 percent of Americans aged 65 years and older have hypertension," the authors provide as background information in the article. "Estimates of the cost of its treatment have ranged from $7 billion to $15.5 billion per year." The authors also note that costs of medications for chronic conditions continue to escalate, particularly for the elderly and that the proportion of seniors without insurance coverage has increased in recent years, as well.
Michael A. Fischer, M.D., M.S., and Jerry Avorn, M.D., from Brigham and Women's Hospital, Harvard Medical School, Boston, analyzed medication use patterns in 133,624 hypertensive patients in a state drug assistance program for elderly patients in Pennsylvania during 2001. The researchers "evaluated every antihypertensive regimen in light of the clinical history of each patient and then estimated the potential cost savings to the health care delivery system that could have been realized through adherence to evidence-based recommendations."
"The patients studied filled more than 2.05 million prescriptions for antihypertensive medications in 2001, at an annual program cost of $48.5 million ($363 per patient)," the researchers found. "We identified 815,316 prescriptions (40 percent) for which an alternative regimen appeared more appropriate according to evidence-based recommendations. Such changes would have reduced the costs to payers in 2001 by $11.6 million (nearly a quarter of program spending on antihypertensive medications), as well as being more clinically appropriate overall."
The researchers found that "calcium channel blockers had the highest average cost ($33.39 per
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