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Improving treatment of medulloblastoma, a common childhood brain tumor

"We clearly need new guidelines for judging how an individual child's tumor is going to behave," Gajjar said. "At present we know that 20 to 30 percent of patients thought to have a good chance of getting cured will actually turn out to be resistant to radiation and chemotherapy. We also can't reliably identify the unknown number of patients who are likely to be over-treated because their tumors are actually more sensitive to radiation than we realized."

International studies, to be conducted by the Children's Oncology Group (COG, US) and the International Scoeity of Pediatric Oncology (SIOP, Europe) over the next several years, will prospectively evaluate the survival significance of molecular prognostic markers among children with medulloblastoma.


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Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
2-Mar-2004


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