HOME >> MEDICINE >> NEWS
Increasing the body's good cholesterol may be a pill away

(Philadelphia, PA) An important clinical advance in the prevention of heart disease has been identified by researchers at the University of Pennsylvania School of Medicine, in collaboration with researchers at Tufts University and Pfizer. The study led by Daniel Rader, MD, Associate Professor of Medicine and Director of Penn's Preventive Cardiovascular Medicine & Lipid Center, involved a novel pharmacologic approach inhibition of the cholesteryl ester transfer protein (CETP) and showed that this approach is highly effective in raising high-density lipoprotein (HDL) levels in patients with low levels. The study will be published in the April 8th issue of The New England Journal of Medicine.

The drug torcetrapib, made by Pfizer, significantly increased levels of HDL in patients with low levels of this "good" cholesterol, whether or not they were also being treated with the cholesterol-lowering drug atorvastatin (Lipitor). The combination therapy used in the trial proved so effective that, among those patients who received the highest dosages of both drugs, HDL cholesterol levels were increased by more than 100%. "These results are striking because it is generally very difficult to raise HDL levels in people with already low-levels of good cholesterol," said Rader.

According to Rader, torcetrapib works by inhibiting the ability of the cholesteryl ester transfer protein to transfer cholesterol from HDL (the "good" cholesterol) into LDL (the "bad" cholesterol). And, although the drug's CETP-inhibitor properties proved effective when administered by itself, its effectiveness was maintained when given in combination with a statin -- which is the most common class of drugs used to lower LDL cholesterol levels.

The implications of this study which took place at Penn and Tufts/New England Medical Center, Boston -- could have far-reaching effects when it comes to heart disease. A low level of HDL cholesterol is the most common lipid abnor
'"/>

Contact: Ed Federico
ed.federico@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
8-Apr-2004


Page: 1 2

Related medicine news :

1. Increasing physician volume requirement could improve mammogram accuracy, study concludes
2. Increasing co-payments may reduce use of essential and non-essential medications
3. Increasing the risk of cancer
4. Increasing number of physician assistants handle more than 190 million patient visits in 2003
5. Increasing MRSA in California jails
6. Increasing BMD could save Medicare $15 million
7. Survey Finds Increasing Popularity Of Acute Stroke Teams In U.S. Hospitals
8. White blood cell plays key role in bodys excessive repair response to asthma
9. Comfort-food cravings may be bodys attempt to put brake on chronic stress
10. Penn State College of Medicine awarded $6.9 million to create clearer images of bodys interior
11. Intensive exercise improves bodys ability to process blood sugars

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... ... ... wait is finally over. The first wild card for the 2020 Tour de Pologne has ... sports to a truly special project. , The group was originally formed with the aim ... They decided to take on the ambitious mission to show that diabetes does not have ...
(Date:2/10/2020)... ... February 10, 2020 , ... A January 26 article ... certain situations. The answer is that – not unlike the skin’s response to dangerous ... sensitivity serve as an alert to potential damage being done and warn the individual ...
(Date:2/10/2020)... ... ... C. A. Shively officially formed The Association of Young Business Owners (AYBOS) in ... business as a majority label stakeholder in Hustle N Flow (HNF) Music Group. Shively ... create any music compositions needed for AYBOS. No one from AYBOS would have ever ...
(Date:2/10/2020)... ... February 10, 2020 , ... How About That’s Sweet Trail Mix is a blend of keto ... 17 grams of fat, 4 grams of protein and 3 grams of net carbs with ... and sea salt, making it the cleanest keto trail mix on the market. , The ...
(Date:2/10/2020)... ... February 10, 2020 , ... ... of relaxation via the administration of ProNox “laughing-gas”," says Dr. Crutchfield. "The patients ... Dermatology announced this week the addition of a new tool to help patients ...
Breaking Medicine News(10 mins):
(Date:2/10/2020)... ... February 10, 2020 , ... ... MS, RDN, has been selected as the chief of Nutrition and Food Service ... food service operations and clinical nutrition programs for the health care system’s three ...
(Date:2/10/2020)... Mo. (PRWEB) , ... February 10, 2020 , ... ... 20 years of experience, most recently in home health and hospice, announced today ... revenue cycle management for home health and hospice agencies, regardless of EHR, across ...
(Date:2/8/2020)... ... February 07, 2020 , ... The first dedicated CBD store ... national recognition. While this exciting rebrand will bring together a brick and mortar location ... the same supreme quality products they have been known for. The product line will ...
Breaking Medicine Technology:
Cached News: