HOME >> MEDICINE >> NEWS
Infectious agent linked to mad cow disease found in organs other than the brain

Prions, infectious proteins associated with bovine spongiform encephalopathy (BSE) or Mad Cow Disease, were previously thought to accumulate mainly in the brain, but Yale and University of Zurich researchers report in Science that other organs can also become infected.

Past research had shown that the brain and spinal cord bear the highest infection risk for BSE, followed by organs such as the spleen, lymph nodes and tonsils. All other organs were thought to be devoid of prions.

Ruddle and co-authors analyzed three organ systems that are typically free of prions: liver, pancreas and kidney, in five different mouse models of chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the spectrum of organs containing prions might be considerably increased in situations of chronic inflammation.

"The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflammation due to microbial infection or autoimmune disease," said Nancy H. Ruddle, the John Rodman Paul Professor and Director of Graduate Studies in the Department of Epidemiology and Public Health at the Yale School of Medicine.

Previous research in Adriano Aguzzi's group at the Institute of Neuropathology at University of Zurich showed that B cells are essential for the spread of prions to organs other than the brain. B cells are found in lymphoid organs in healthy humans and animals, but they can migrate into non-lymphoid organs under inflammatory circumstances.

Other researchers on the study include first author Mathias Heikenwalder, Nicolas Zeller, Harald Seeger, Marco Prinz, Peter-Christian Klohn, Petra Schwarz, Charles Weissman and the director of the study, Adriano Aguzzi.

Ruddle's portion of this study was supported by National Institutes of Health Grant CA 16885.


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
4-Feb-2005


Page: 1

Related medicine news :

1. Infectious microorganism linked to kidney stones and other diseases
2. Infectious disease expert to speak at American Academy of Ophthalmologys annual meeting
3. The Lancet Infectious Diseases (TLID)
4. The Lancet Oncology (TLO) and the Lancet Infectious Diseases (TLID)
5. UCSDs Victor Nizet, M.D., receives Pediatric Infectious Diseases Award
6. The Lancet Infectious Diseases (TLID)
7. The Lancet Oncology (TLO) and The Lancet Infectious Diseases (TLID)
8. The Lancet Oncology and The Lancet Infectious Diseases
9. Infectious disease researcher available to discuss new federal recommendations aimed at protecting college students from meningococcal meningitis
10. New Model Shows How To Eradicate Worlds Leading Infectious Cause Of Blindness
11. New highly active agents against sandfly fever

Post Your Comments:
(Date:5/27/2015)... In today's healthcare landscape, where costs ... be challenging for doctors and hospitals to keep up ... , Austin-based HealthTronics, Inc. is offering a ... therapies for clinically sophisticated applications. The company has now ... Laser Ventures, Inc ., a mobile laser technology ...
(Date:5/27/2015)... 2015 Dr. Omar Ibrahimi, Dermatologist and ... CT has been selected as part of a controlled ... (and the only physician in Connecticut) to offer the ... the removal of submental fat (double chin). The procedure ... no surgery and minimal risks. Dr. Ibrahimi is an ...
(Date:5/27/2015)... NOVAtime Technology, Inc. ( http://www.novatime.com ), a ... organizations, announced today that SanMar Corporation successfully implemented ... attendance and point tracking processes for over 3,000 ... , Family-owned since 1971, Seattle-based SanMar Corporation ... label, and mill brands. SanMar supplies apparel and ...
(Date:5/27/2015)... 2015 In support of a ... of the Journal of American Geriatrics Society about the ... Bedford Commons OB-GYN P.A . is reiterating the ... beverages. , To examine the relationship between diet ... Antonio Longitudinal Study of Aging (SALSA) tracked the soda ...
(Date:5/27/2015)... 2015 The Case Management Society ... to provide CMSA's Career and Knowledge Pathways educational ... to strengthen the case/care management workforce by offering ... The mutually beneficial agreement provides Medix, a workforce ... talent in the healthcare, scientific and IT industries, ...
Breaking Medicine News(10 mins):Health News:HealthTronics Invests in Additional Mobile Medical Technologies As Cost Efficient Solution for Hospitals, Doctors 2Health News:HealthTronics Invests in Additional Mobile Medical Technologies As Cost Efficient Solution for Hospitals, Doctors 3Health News:Connecticut Skin Institute First in Connecticut to Offer New Surgery-Free “Double Chin” Fat Reduction Treatment 2Health News:Connecticut Skin Institute First in Connecticut to Offer New Surgery-Free “Double Chin” Fat Reduction Treatment 3Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 2Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 3Health News:Recent Study About the Link Between Diet Sodas and Abdominal Fat Reinforces Bedford Commons OB-GYN's Recommendation to Drink Plenty of Water 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 3
(Date:5/27/2015)... -- LumiThera Inc., a developmental stage medical device company ... disorders and disease, announced today that they were ... Life Sciences Discovery Fund (LSDF) commercialization grant. LumiThera was ... grants worth $500,000 to provide for commercialization activities ... macular degeneration (AMD). LSDF executive ...
(Date:5/27/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/nt9zlx/asia_pacific ) has announced the ... Growth, Trends And Forecasts (2014 - 2019)" company ... detailed type of imaging that customs a low-dose x-ray ... mammogram, is used to support in the early detection ... (radiograph) is a noninvasive medical test that helps physicians ...
(Date:5/27/2015)... 2015 The report " Tube Packaging Market ... Oral Care, Food & beverages, Pharmaceuticals, Consumer Goods), by Material ... - Trends & Forecasts to 2020", published by MarketsandMarkets, The ... a CAGR of 6.65% from 2015, to reach $8,638.9 Million ... Tables and   61 F igures spread thro ...
Breaking Medicine Technology:LumiThera Receives LSDF Commercialization Grant Award 2Asia Pacific Mammography Market Trends and Forecasts 2015-2019 2Tube Packaging Market Worth $8.63 Billion by 2020 2Tube Packaging Market Worth $8.63 Billion by 2020 3Tube Packaging Market Worth $8.63 Billion by 2020 4
Cached News: