HOME >> MEDICINE >> NEWS
Infectious agent linked to mad cow disease found in organs other than the brain

Prions, infectious proteins associated with bovine spongiform encephalopathy (BSE) or Mad Cow Disease, were previously thought to accumulate mainly in the brain, but Yale and University of Zurich researchers report in Science that other organs can also become infected.

Past research had shown that the brain and spinal cord bear the highest infection risk for BSE, followed by organs such as the spleen, lymph nodes and tonsils. All other organs were thought to be devoid of prions.

Ruddle and co-authors analyzed three organ systems that are typically free of prions: liver, pancreas and kidney, in five different mouse models of chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the spectrum of organs containing prions might be considerably increased in situations of chronic inflammation.

"The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflammation due to microbial infection or autoimmune disease," said Nancy H. Ruddle, the John Rodman Paul Professor and Director of Graduate Studies in the Department of Epidemiology and Public Health at the Yale School of Medicine.

Previous research in Adriano Aguzzi's group at the Institute of Neuropathology at University of Zurich showed that B cells are essential for the spread of prions to organs other than the brain. B cells are found in lymphoid organs in healthy humans and animals, but they can migrate into non-lymphoid organs under inflammatory circumstances.

Other researchers on the study include first author Mathias Heikenwalder, Nicolas Zeller, Harald Seeger, Marco Prinz, Peter-Christian Klohn, Petra Schwarz, Charles Weissman and the director of the study, Adriano Aguzzi.

Ruddle's portion of this study was supported by National Institutes of Health Grant CA 16885.


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
4-Feb-2005


Page: 1

Related medicine news :

1. Infectious microorganism linked to kidney stones and other diseases
2. Infectious disease expert to speak at American Academy of Ophthalmologys annual meeting
3. The Lancet Infectious Diseases (TLID)
4. The Lancet Oncology (TLO) and the Lancet Infectious Diseases (TLID)
5. UCSDs Victor Nizet, M.D., receives Pediatric Infectious Diseases Award
6. The Lancet Infectious Diseases (TLID)
7. The Lancet Oncology (TLO) and The Lancet Infectious Diseases (TLID)
8. The Lancet Oncology and The Lancet Infectious Diseases
9. Infectious disease researcher available to discuss new federal recommendations aimed at protecting college students from meningococcal meningitis
10. New Model Shows How To Eradicate Worlds Leading Infectious Cause Of Blindness
11. New highly active agents against sandfly fever

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2017)... (PRWEB) , ... June 25, 2017 , ... CareSet Labs ... in New Orleans. This is a new, greatly improved version of the Doctor ... Act (FOIA) requests by Fred Trotter and subsequently called the the “Doctor Referral Dataset” ...
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic Trainers’ Society’s ... and Erie Convention Center on June 8-10. The weekend consisted of many ... award and scholarship presentations, and professional networking. , On Friday June 9th, ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode ... of Care Management Alerts and Dashboards, an innovative new service enabling healthcare providers ... RIQI’s Care Management Alerts and Dashboards provide near real-time data about patients admitted ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids and ... of visual loss in these patients. , But how often do ophthalmologists and optometrists ... to patients at risk of or with early symptoms of AMD? A study ...
(Date:6/23/2017)... ... ... Everybody has their own personal preference when it comes to pornography. Some ... don't like it at all. FindaTopDoc took a look at what makes people attracted ... readers a taste of their deepest, darkest fantasies and has the ability to help ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... and INDIANAPOLIS , June 9, 2017 ... with diabetes. In a further effort to help spread ... by this condition, the International Diabetes Federation (IDF) and ... have come together for the second phase of the ... programme (BRIDGES 2), reaffirming their commitment to helping people ...
(Date:6/8/2017)... , June 8, 2017  StatLab Medical ... developer and manufacturer of diagnostic supplies for ... that Cressey & Company LP ("Cressey & ... completed a growth-focused investment in the Company. ... ownership position from selling shareholder, Prairie Capital, ...
(Date:6/7/2017)... 2017  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, ... Iowa location. The ... features an ISO 7 cleanroom—the standard needed to compound intravenous (IV) ... level of pollutants. "Our new ... better serve our Iowa patients," said ...
Breaking Medicine Technology:
Cached News: