HOME >> MEDICINE >> NEWS
Infectious agent linked to mad cow disease found in organs other than the brain

Prions, infectious proteins associated with bovine spongiform encephalopathy (BSE) or Mad Cow Disease, were previously thought to accumulate mainly in the brain, but Yale and University of Zurich researchers report in Science that other organs can also become infected.

Past research had shown that the brain and spinal cord bear the highest infection risk for BSE, followed by organs such as the spleen, lymph nodes and tonsils. All other organs were thought to be devoid of prions.

Ruddle and co-authors analyzed three organ systems that are typically free of prions: liver, pancreas and kidney, in five different mouse models of chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the spectrum of organs containing prions might be considerably increased in situations of chronic inflammation.

"The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflammation due to microbial infection or autoimmune disease," said Nancy H. Ruddle, the John Rodman Paul Professor and Director of Graduate Studies in the Department of Epidemiology and Public Health at the Yale School of Medicine.

Previous research in Adriano Aguzzi's group at the Institute of Neuropathology at University of Zurich showed that B cells are essential for the spread of prions to organs other than the brain. B cells are found in lymphoid organs in healthy humans and animals, but they can migrate into non-lymphoid organs under inflammatory circumstances.

Other researchers on the study include first author Mathias Heikenwalder, Nicolas Zeller, Harald Seeger, Marco Prinz, Peter-Christian Klohn, Petra Schwarz, Charles Weissman and the director of the study, Adriano Aguzzi.

Ruddle's portion of this study was supported by National Institutes of Health Grant CA 16885.


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
4-Feb-2005


Page: 1

Related medicine news :

1. Infectious microorganism linked to kidney stones and other diseases
2. Infectious disease expert to speak at American Academy of Ophthalmologys annual meeting
3. The Lancet Infectious Diseases (TLID)
4. The Lancet Oncology (TLO) and the Lancet Infectious Diseases (TLID)
5. UCSDs Victor Nizet, M.D., receives Pediatric Infectious Diseases Award
6. The Lancet Infectious Diseases (TLID)
7. The Lancet Oncology (TLO) and The Lancet Infectious Diseases (TLID)
8. The Lancet Oncology and The Lancet Infectious Diseases
9. Infectious disease researcher available to discuss new federal recommendations aimed at protecting college students from meningococcal meningitis
10. New Model Shows How To Eradicate Worlds Leading Infectious Cause Of Blindness
11. New highly active agents against sandfly fever

Post Your Comments:
(Date:7/6/2015)... ... July 06, 2015 , ... Dr. Lawrence Green is now offering the newly ... is a non-surgical method to dissolve fat cells and is the first of ... deposits under the chin, commonly known as a double chin. Dr. Green participated in ...
(Date:7/6/2015)... , ... July 06, 2015 , ... ... Jeffrey R. Carlson finished his 100th case using SpineFrontier’s® PedFuse® REmind® Screws. The ... Hospital in Newport News, VA. The procedure was an L5-S1 posterior lumbar interbody ...
(Date:7/6/2015)... ... 06, 2015 , ... Thanks to donations and a generous grant from the ... Memory Certification for hospice patients and adult day center participants. , The Music & ... but also to their families and volunteers. Music & Memory is a non-profit organization ...
(Date:7/5/2015)... ... July 06, 2015 , ... Security ... excited to announce the next generation of PrimeStar Individual Dental Insurance. Beginning now, ... include two network options—Maximum Allowable Charge (MAC) and usual, customary and reasonable (UCR). ...
(Date:7/5/2015)... ... July 05, 2015 , ... Women's Excellence in Wellness, powered by ... These classes are geared towards families that want their children to stay active as ... The fitness class will take place TUESDAYS at 4:30pm. Questions? Call 248-601-6683. Women’s ...
Breaking Medicine News(10 mins):Health News:Rockville, MD Practice Now Offering New FDA-Approved Non-Surgical Double Chin Treatment 2Health News:100th Outpatient Less Exposure Surgery Procedure Completed by Industry Leading Surgeon Dr. Jeffrey Carlson 2Health News:100th Outpatient Less Exposure Surgery Procedure Completed by Industry Leading Surgeon Dr. Jeffrey Carlson 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 2Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 4Health News:Security Life Insurance Company of America Launches the Next Generation of PrimeStar Individual Dental Insurance Plans 2
(Date:7/3/2015)... A global continuing medical education provider is ... in Central and South-East Asia ... dedicated to these diseases.      (Logo: http://photos.prnewswire.com/prnh/20150630/227090) ... Manage Hypertension Online and Manage Thyroid Online ... - combine the world,s top expertise with dynamic ...
(Date:7/3/2015)... , July 3, 2015  Obsidian HDS, the developer ... online service for the management of data on pharmaceutical ... that PharmaShine now includes the 2014 Open Payments General ... Services on June 30. The data disclosed on Open ... between industry and providers totaling $6.49 billion and is ...
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ... common shares have been approved for listing and trading on ... ESSA will begin trading on NASDAQ on July 9, ... Venture Exchange under the symbol "EPI". As a ... NASDAQ, each of the Company,s outstanding special warrants issued on ...
Breaking Medicine Technology:Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2New Open Payments (Sunshine Act) Data Now Searchable on PharmaShine 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4
Cached News: