HOME >> MEDICINE >> NEWS
Infectious agent linked to mad cow disease found in organs other than the brain

Prions, infectious proteins associated with bovine spongiform encephalopathy (BSE) or Mad Cow Disease, were previously thought to accumulate mainly in the brain, but Yale and University of Zurich researchers report in Science that other organs can also become infected.

Past research had shown that the brain and spinal cord bear the highest infection risk for BSE, followed by organs such as the spleen, lymph nodes and tonsils. All other organs were thought to be devoid of prions.

Ruddle and co-authors analyzed three organ systems that are typically free of prions: liver, pancreas and kidney, in five different mouse models of chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the spectrum of organs containing prions might be considerably increased in situations of chronic inflammation.

"The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflammation due to microbial infection or autoimmune disease," said Nancy H. Ruddle, the John Rodman Paul Professor and Director of Graduate Studies in the Department of Epidemiology and Public Health at the Yale School of Medicine.

Previous research in Adriano Aguzzi's group at the Institute of Neuropathology at University of Zurich showed that B cells are essential for the spread of prions to organs other than the brain. B cells are found in lymphoid organs in healthy humans and animals, but they can migrate into non-lymphoid organs under inflammatory circumstances.

Other researchers on the study include first author Mathias Heikenwalder, Nicolas Zeller, Harald Seeger, Marco Prinz, Peter-Christian Klohn, Petra Schwarz, Charles Weissman and the director of the study, Adriano Aguzzi.

Ruddle's portion of this study was supported by National Institutes of Health Grant CA 16885.


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
4-Feb-2005


Page: 1

Related medicine news :

1. Infectious microorganism linked to kidney stones and other diseases
2. Infectious disease expert to speak at American Academy of Ophthalmologys annual meeting
3. The Lancet Infectious Diseases (TLID)
4. The Lancet Oncology (TLO) and the Lancet Infectious Diseases (TLID)
5. UCSDs Victor Nizet, M.D., receives Pediatric Infectious Diseases Award
6. The Lancet Infectious Diseases (TLID)
7. The Lancet Oncology (TLO) and The Lancet Infectious Diseases (TLID)
8. The Lancet Oncology and The Lancet Infectious Diseases
9. Infectious disease researcher available to discuss new federal recommendations aimed at protecting college students from meningococcal meningitis
10. New Model Shows How To Eradicate Worlds Leading Infectious Cause Of Blindness
11. New highly active agents against sandfly fever

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2019)... Fla. (PRWEB) , ... August 23, 2019 , ... ... a strategic partnership with the West Virginia Eye Collaborative. This partnership will be ... value, and access of care, the WV Eye Collaborative and its eye physicians ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... new location in Huntsville, Ala. in early 2020. Alsana will offer an eating ... an Intensive Outpatient Program (IOP). The integrative program will provide a continuum of ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... Sunday, July 28. The Phase II expansion of Providence Point in Pittsburgh’s Scott ... well as construction of the 70-unit apartment tower, Hamilton Tower. , ...
(Date:8/19/2019)... ... , ... Professional Enrollment Concepts (PEC), a top benefits enrollment ... ranked #3056 on the 2019 Inc. 5000 Fastest-Growing Private Companies list. The list ... successful companies within the American economy's most dynamic segment—its independent small and mid-sized ...
(Date:8/17/2019)... Fla. (PRWEB) , ... August 17, 2019 , ... ... Annual List of America’s Fastest-Growing Private Companies—the Inc. 5000 , For the 2nd ... 2098 With Three-Year Revenue Growth of 192% Percent , Inc. magazine today revealed ...
Breaking Medicine News(10 mins):
(Date:8/21/2019)... ... August 21, 2019 , ... Impact Advisors , a ... announced today that it has been named to Inc. magazine’s Inc. 5000 list. The ... for-profit companies with significant percentage revenue growth. This year the firm was also named ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... today announced the findings of research validating the clinical impact of MedAware’s machine ... published 7 August 2019 in the Journal of American Medical Informatics Association ...
(Date:8/19/2019)... ... 19, 2019 , ... The International Association of Eating Disorders ... the field of treatment for eating disorders, recommends membership for professionals who are ... a similar mission. , Founded in 1985, the iaedp™ Foundation is the ...
Breaking Medicine Technology:
Cached News: