HOME >> MEDICINE >> NEWS
Infectious agent linked to mad cow disease found in organs other than the brain

Prions, infectious proteins associated with bovine spongiform encephalopathy (BSE) or Mad Cow Disease, were previously thought to accumulate mainly in the brain, but Yale and University of Zurich researchers report in Science that other organs can also become infected.

Past research had shown that the brain and spinal cord bear the highest infection risk for BSE, followed by organs such as the spleen, lymph nodes and tonsils. All other organs were thought to be devoid of prions.

Ruddle and co-authors analyzed three organ systems that are typically free of prions: liver, pancreas and kidney, in five different mouse models of chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the spectrum of organs containing prions might be considerably increased in situations of chronic inflammation.

"The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflammation due to microbial infection or autoimmune disease," said Nancy H. Ruddle, the John Rodman Paul Professor and Director of Graduate Studies in the Department of Epidemiology and Public Health at the Yale School of Medicine.

Previous research in Adriano Aguzzi's group at the Institute of Neuropathology at University of Zurich showed that B cells are essential for the spread of prions to organs other than the brain. B cells are found in lymphoid organs in healthy humans and animals, but they can migrate into non-lymphoid organs under inflammatory circumstances.

Other researchers on the study include first author Mathias Heikenwalder, Nicolas Zeller, Harald Seeger, Marco Prinz, Peter-Christian Klohn, Petra Schwarz, Charles Weissman and the director of the study, Adriano Aguzzi.

Ruddle's portion of this study was supported by National Institutes of Health Grant CA 16885.


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
4-Feb-2005


Page: 1

Related medicine news :

1. Infectious microorganism linked to kidney stones and other diseases
2. Infectious disease expert to speak at American Academy of Ophthalmologys annual meeting
3. The Lancet Infectious Diseases (TLID)
4. The Lancet Oncology (TLO) and the Lancet Infectious Diseases (TLID)
5. UCSDs Victor Nizet, M.D., receives Pediatric Infectious Diseases Award
6. The Lancet Infectious Diseases (TLID)
7. The Lancet Oncology (TLO) and The Lancet Infectious Diseases (TLID)
8. The Lancet Oncology and The Lancet Infectious Diseases
9. Infectious disease researcher available to discuss new federal recommendations aimed at protecting college students from meningococcal meningitis
10. New Model Shows How To Eradicate Worlds Leading Infectious Cause Of Blindness
11. New highly active agents against sandfly fever

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/22/2017)... ... 22, 2017 , ... Today, Our Urgent Care celebrates the grand opening of ... cutting ceremony. Since opening over a month ago, Our Urgent Care Washington has ... The new Our Urgent Care walk-in clinic is located at 3195 Phoenix Center Dr., ...
(Date:5/22/2017)... ... May 22, 2017 , ... WeightZone Factor a ... empower WeightZone Factor members to track their exercise patterns, monitor behavioral changes, employ ... all on their mobile phones. It also provides social networks for members with ...
(Date:5/21/2017)... (PRWEB) , ... May 20, 2017 , ... ... styled corporate text designs created specifically for use in Final Cut Pro X. ... for all media productions. Pixel Film Studios’ ProParagraph Corporate will deliver a professional ...
(Date:5/21/2017)... ... 21, 2017 , ... Following the tragic and widely publicized death of Rory ... require that hospitals follow a protocol to quickly identify and treat the condition. ... such steps would have saved Rory or anyone else’s life. , Now, five ...
(Date:5/19/2017)... ... May 19, 2017 , ... When Kyle Busch graduates from ... will already appear on two major research studies that could impact the health of ... Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside an international team trying to ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Mass., May 10, 2017 Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended April 1, ... of $1.84 increased 666.7% compared to the prior year ... resulted in a significant gain, while non-GAAP diluted EPS ... 3.2%, or 3.8% in constant currency terms.  Excluding the ...
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)... 9, 2017  Demonstrating its commitment to representing ... for the Pharmaceutical Research and Manufacturers of America ... companies will now have to meet new research ... eligible to join PhRMA. "By putting ... sending a clear message that being a member ...
Breaking Medicine Technology:
Cached News: