Inflammatory pain may help deter inflammatory diseases like arthritis

Pain alerts the body to danger, but UC San Francisco researchers report that it may play another crucial role - helping to prevent the body from slipping into the chronic inflammation associated with such diseases as arthritis, colitis and asthma.

The finding, published in the September issue of Nature Medicine, provides the first evidence -- after years of inquiry -- of an active process controlling inflammation, and may open a new window to understanding the mechanisms at the heart of chronic inflammatory diseases.

People experience pain when signals from specialized nerve fibers are activated. These pain nerve fibers are triggered when tissue is damaged. They are re-activated by inflammation, the body's normally beneficial response to trauma and infection.

Inflammation increases blood flow to the site of injury and sends in a flood of rescue factors - such as substances that clot wounds and white blood cells that chew up invading disease-causing pathogens -to the site. But research has shown that unrestrained inflammation can cause chronic, debilitating diseases.

Traditionally, researchers have thought that the factors involved in the inflammatory response ultimately dissipated on their own. But the UCSF study suggests that activated pain nerve fibers, themselves, dampen the inflammatory response's first line of attack -- a cell known as the neutrophil, which sweeps into an injured site, releasing chemicals that work to heal wounds.

"Our work suggests that pain acts as a negative feedback control of inflammation," said the lead author of the study, Holly Strausbaugh, PhD, a postdoctoral fellow in the NIH Pain Center at UCSF. "Once enough inflammation builds up that pain nerve fibers are activated, the inflammatory response begins to diminish. Failure of this mechanism could contribute to the development of chronic inflammatory disease."

Notably, said Strausbaugh, pain fibers are not activated until the inflammatory response is we

Contact: Jennifer O'Brien
University of California - San Francisco

Page: 1 2 3 4

Related medicine news :

1. Inflammatory cells highly promising target in NF 1
2. Inflammatory marker may be early sign of blood vessel blockages
3. New Anti-Inflammatory Drug Is Easy On The Stomach
4. Specific test key to determine whether or not allergy symptoms are really allergy-related
5. Age should not be a factor in determining heart transplantation eligibility, researchers say
6. Sequential MDCT sufficient for determining possible risk of coronary artery disease
7. Study determines commonly used contrast agent safe for universal use in CT
8. MDCT angiography can potentially help determine which patients are at greater risk of stroke
9. PITT, OHSU: When early life stress occurs determines its impact later
10. Blood pressure drugs may slow deterioration of Alzheimers
11. Parkinsons caregivers at risk for deteriorating health

Post Your Comments:

(Date:11/25/2015)... ALTO, Calif. (PRWEB) , ... November 25, 2015 , ... ... Smart and Beddit Classic sleep tracking systems. The new app features a more intuitive ... see and understand how well you slept. The SleepScore is created by a proprietary ...
(Date:11/25/2015)... LOUIS, Missouri (PRWEB) , ... November 25, 2015 ... ... Project HEAL, will provide scholarships for people struggling with eating disorders as a ... Proceeds from the second annual event, held at Fox Run Golf Club in ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the common ... cold hands, and dry skin. But many people who find their cholesterol levels and ... instead of their thyroid, especially if they don’t have any of the other symptoms. ...
(Date:11/24/2015)... ... November 25, 2015 , ... ... Their Care Plan software creates an agreement between the practice owner and ... including financial, scheduling, monitoring, notification, and projections. Click here to ...
(Date:11/24/2015)... Texas (PRWEB) , ... November 24, 2015 , ... Charitable ... all charitable donations are made in the last five weeks of the year totalling ... was created in 2012 to connect the nation’s charities with those individuals who want ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... SAN DIEGO , Nov. 25, 2015  Trovagene, ... molecular diagnostics, today announced that Chief Executive Officer Antonius ... at the 27 th Annual Piper Jaffray Healthcare ... Conference at the New York Palace Hotel in ... 2015 at 1:30 p.m. EST. Mr. Schuh will be ...
(Date:11/25/2015)... Endo International plc (NASDAQ: ENDP ) (TSX: ... and CEO, will discuss corporate updates at the 27 th ... York on Wednesday, December 2, 2015 at 1 ... Relations, and then the link to the event. Participants should ... to visit the site and download any streaming media software ...
(Date:11/25/2015)... Israel , November 25, 2015 ... "New Investors"), pursuant to which BioLight and the New ... IOPtima Ltd. subsidiary ("IOPtima") via a private placement. The ... of its innovative IOPtimate™ system used in the treatment ... approval pathway process for the IOPtimate™ system with the ...
Breaking Medicine Technology:
Cached News: