HOME >> MEDICINE >> NEWS
Inflammatory pain may help deter inflammatory diseases like arthritis

Pain alerts the body to danger, but UC San Francisco researchers report that it may play another crucial role - helping to prevent the body from slipping into the chronic inflammation associated with such diseases as arthritis, colitis and asthma.

The finding, published in the September issue of Nature Medicine, provides the first evidence -- after years of inquiry -- of an active process controlling inflammation, and may open a new window to understanding the mechanisms at the heart of chronic inflammatory diseases.

People experience pain when signals from specialized nerve fibers are activated. These pain nerve fibers are triggered when tissue is damaged. They are re-activated by inflammation, the body's normally beneficial response to trauma and infection.

Inflammation increases blood flow to the site of injury and sends in a flood of rescue factors - such as substances that clot wounds and white blood cells that chew up invading disease-causing pathogens -to the site. But research has shown that unrestrained inflammation can cause chronic, debilitating diseases.

Traditionally, researchers have thought that the factors involved in the inflammatory response ultimately dissipated on their own. But the UCSF study suggests that activated pain nerve fibers, themselves, dampen the inflammatory response's first line of attack -- a cell known as the neutrophil, which sweeps into an injured site, releasing chemicals that work to heal wounds.

"Our work suggests that pain acts as a negative feedback control of inflammation," said the lead author of the study, Holly Strausbaugh, PhD, a postdoctoral fellow in the NIH Pain Center at UCSF. "Once enough inflammation builds up that pain nerve fibers are activated, the inflammatory response begins to diminish. Failure of this mechanism could contribute to the development of chronic inflammatory disease."

Notably, said Strausbaugh, pain fibers are not activated until the inflammatory response is we
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Aug-1999


Page: 1 2 3 4

Related medicine news :

1. Inflammatory cells highly promising target in NF 1
2. Inflammatory marker may be early sign of blood vessel blockages
3. New Anti-Inflammatory Drug Is Easy On The Stomach
4. Specific test key to determine whether or not allergy symptoms are really allergy-related
5. Age should not be a factor in determining heart transplantation eligibility, researchers say
6. Sequential MDCT sufficient for determining possible risk of coronary artery disease
7. Study determines commonly used contrast agent safe for universal use in CT
8. MDCT angiography can potentially help determine which patients are at greater risk of stroke
9. PITT, OHSU: When early life stress occurs determines its impact later
10. Blood pressure drugs may slow deterioration of Alzheimers
11. Parkinsons caregivers at risk for deteriorating health

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/21/2017)... ... April 21, 2017 , ... Evoke Therapy ... adults, has kicked off its 4th annual Forum for Innovative Treatment Solutions (FITS), ... “Attachment Informed Therapy for Mental Health and Addiction.” , FITS’ 2017 keynote ...
(Date:4/21/2017)... ... 2017 , ... The Patient Advocacy Community of The Beryl Institute presented Eve ... Ravich Patient Advocacy Award in recognition of her extraordinary contributions to the field ... at The Beryl Institute’s annual Patient Experience Conference on March 20 in ...
(Date:4/21/2017)... , ... April 21, 2017 , ... Alive for ... who wish to overcome their mental health struggles. The Alive team uses advanced ... says: “Our approach in dealing with a mental health struggle is based on ...
(Date:4/21/2017)... ... 2017 , ... Providing for loved ones before one’s passing is of paramount ... even begin. “Now more than ever there are some questions that are far too ... family,” said attorney Lisa Edgar Dickman, founder of the Law Offices of Lisa Edgar ...
(Date:4/21/2017)... ... 2017 , ... During April 21-23, Super-Sod will join the vendor market of ... for everyone — from the avid gardener to the landscape admirer — during the ... held in a grand venue, and we are certainly looking forward to participating in ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017  CVS Pharmacy, the retail ... a new store design to enhance the retail ... food, health-focused products and expanded beauty selections paired ... customers discover new offerings. Together with its innovative ... of the customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... Eyevensys, a private biotechnology company developing its ... that enables the safe, local, sustained production of therapeutic ... of ophthalmic diseases, announces it has received approval from ... to advance its technology into clinical development. ... The EyeCET platform uses ...
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment is ... period The Cardiology Devices segment is likely to ... 15 Mn in 2018 over 2017. By the end of ... valuation close to US$ 700 Mn, expanding at a CAGR ... dominated the Asia Pacific reprocessed medical ...
Breaking Medicine Technology:
Cached News: