HOME >> MEDICINE >> NEWS
Inflammatory pain may help deter inflammatory diseases like arthritis

Pain alerts the body to danger, but UC San Francisco researchers report that it may play another crucial role - helping to prevent the body from slipping into the chronic inflammation associated with such diseases as arthritis, colitis and asthma.

The finding, published in the September issue of Nature Medicine, provides the first evidence -- after years of inquiry -- of an active process controlling inflammation, and may open a new window to understanding the mechanisms at the heart of chronic inflammatory diseases.

People experience pain when signals from specialized nerve fibers are activated. These pain nerve fibers are triggered when tissue is damaged. They are re-activated by inflammation, the body's normally beneficial response to trauma and infection.

Inflammation increases blood flow to the site of injury and sends in a flood of rescue factors - such as substances that clot wounds and white blood cells that chew up invading disease-causing pathogens -to the site. But research has shown that unrestrained inflammation can cause chronic, debilitating diseases.

Traditionally, researchers have thought that the factors involved in the inflammatory response ultimately dissipated on their own. But the UCSF study suggests that activated pain nerve fibers, themselves, dampen the inflammatory response's first line of attack -- a cell known as the neutrophil, which sweeps into an injured site, releasing chemicals that work to heal wounds.

"Our work suggests that pain acts as a negative feedback control of inflammation," said the lead author of the study, Holly Strausbaugh, PhD, a postdoctoral fellow in the NIH Pain Center at UCSF. "Once enough inflammation builds up that pain nerve fibers are activated, the inflammatory response begins to diminish. Failure of this mechanism could contribute to the development of chronic inflammatory disease."

Notably, said Strausbaugh, pain fibers are not activated until the inflammatory response is we
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Aug-1999


Page: 1 2 3 4

Related medicine news :

1. Inflammatory cells highly promising target in NF 1
2. Inflammatory marker may be early sign of blood vessel blockages
3. New Anti-Inflammatory Drug Is Easy On The Stomach
4. Specific test key to determine whether or not allergy symptoms are really allergy-related
5. Age should not be a factor in determining heart transplantation eligibility, researchers say
6. Sequential MDCT sufficient for determining possible risk of coronary artery disease
7. Study determines commonly used contrast agent safe for universal use in CT
8. MDCT angiography can potentially help determine which patients are at greater risk of stroke
9. PITT, OHSU: When early life stress occurs determines its impact later
10. Blood pressure drugs may slow deterioration of Alzheimers
11. Parkinsons caregivers at risk for deteriorating health

Post Your Comments:
(Date:5/24/2013)... HealthDay Reporter , , FRIDAY, May 24 (HealthDay News) -- ... But it was a physical challenge in her childhood ... sport. "I was an 11-year-old girl with my ... diagnosed by my orthopedic surgeon," said Lewis, who has ... and the American Academy of Orthopaedic Surgeons so she ...
(Date:5/24/2013)... Pomona, Calif. (PRWEB) May 24, 2013 ... has retained its status of “Full Accreditation” for the ... (AVMA) Council on Education (COE). , “This is a ... of our hard work and student outcomes,” said College ... want to express my appreciation to the faculty, staff, ...
(Date:5/24/2013)... KC and Monica Craichy, Founders of Living Fuel, Inc ... Kyle and Austin Craichy, will be kiteboarding with members of ... , KC Craichy said he is excited to be involved ... that virtually everyone who planned to be involved is going ... meet at Matheson Hammock Park and Beach in Miami at ...
(Date:5/24/2013)... The Mirena IUD lawyers at ... the FDA has received more than 59,229 complaints since 2004 ... intrauterine birth control device known as the Mirena IUD.* , ... by the women “included ‘expulsion,’ where the IUD came out ... according to an ABC News article. “Abdominal pain is also ...
(Date:5/24/2013)... 2013 E-Dentists.com has announced the launch ... JD Media Surge, a leading medical Internet marketing agency. ... analysis service will focus on providing dentists the help ... for their competitive keywords. The dental SEO analysis covers ... based on what their competitors are doing right. The ...
Breaking Medicine News(10 mins):Health News:Top-Ranked Golfer Beats Scoliosis 2Health News:Top-Ranked Golfer Beats Scoliosis 3Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2Health News:Dental SEO Analysis Launched by E-Dentists.com in Partnership with JD Media Surge 2
(Date:5/24/2013)... , May 24, 2013 China Biologic Products, ... leading fully integrated plasma-based biopharmaceutical company in ... recently learned from a public announcement issued by Shanghai ... company listed on Shenzhen Stock Exchange, that on May ... ("Ms. Chan"), one of the shareholders of the ...
(Date:5/24/2013)... 24, 2013 In accordance with Rule 17.1 and ... of the United States Exchange Act, Echo Pharma Acquisition Limited ... Elan Corporation (NYSE: ELN). Background On ... an offer for the entire of the issued and to ... "Original Offer").  On 20 May 2013, Royalty ...
(Date:5/24/2013)... , May 24, 2013 The ... for systemic delivery of therapeutic agents has been receiving ... drug delivery showing significant promise. The crucial formulation considerations ... delivery device play a major role in the efficiency ... in the development of new formulation techniques and devices ...
Breaking Medicine Technology:China Biologic Comments on the Proposed Shanghai RAAS Transaction 2China Biologic Comments on the Proposed Shanghai RAAS Transaction 3China Biologic Comments on the Proposed Shanghai RAAS Transaction 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 9Inhalaltion Drug Delivery: 11-12 September - Berlin, Germany 2
Cached News: