HOME >> MEDICINE >> NEWS
Infliximab could offer long-term benefits to people with Crohns disease

Sustained use of the drug infliximab could offer substantial clinical benefit to people with Crohns disease, conclude authors of a study in this weeks issue of THE LANCET.

Crohns disease is a chronic inflammatory disorder of the intestines. Patients often have to be treated with steroids, which are associated with severe side-effects. Previous research has suggested that the drug infliximab could reduce disease symptoms in the short term; Stephen Hanauer and colleagues from the University of Chicago, USA, investigated whether treatment with infliximab every two months could be more effective in reducing the symptoms of Crohns disease in the longer term compared with a single infusion of the drug.

355 patients with severe Crohns disease from the USA, Europe, and Israel who responded within two weeks to an initial 5 mg/kg intravenous infusion of infliximab took part in the study. They were randomly assigned repeat infusions of placebo, repeat infusions of 5 mg/kg infliximab, or 10 mg/kg infliximab (after two treatments with 5mg/kg infliximab). Treatment took place at randomisation, after one month, and thereafter every two months for a year.

More than twice as many people given infliximab every two months were in remission after 30 weeks compared with patients who only received initial infliximab treatment followed by placebo. Patients given sustained infliximab responded for longer (for 38 and 54 weeks for 5mg/kg and 10mg/kg regimens, respectively) compared with patients given placebo (who only responded to treatment for an average of 19 weeks). Patients given infliximab were also more likely to discontinue use of steroids compared with those given placebo.

Stephen Hanauer comments: This study was important to demonstrate a sustained response to maintenance treatment with infliximab in Crohns disease, similar to the results with maintenance treatment for rheumatoid arthritis. After a series of inductive infusions at baseline, 2 and
'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-20-7424-4949
Lancet
2-May-2002


Page: 1 2

Related medicine news :

1. Charcoal and forest management could reduce greenhouse gas levels & save lives in Africa
2. Novel therapy tested in mice could chase away cat allergies
3. Costs of antidepressants could have funded effective alternatives
4. Emergency clopidogrel could save thousands of lives46,000-patient heart attack trial results
5. Blood pressure treatment could cut risk of strokes and heart attacks
6. Proteins found in urine of pregnant women could help diagnose preeclampsia
7. Three out of the four million newborn babies who die each year could be saved
8. Increasing physician volume requirement could improve mammogram accuracy, study concludes
9. Chemicals in apples could reduce the risk of breast cancer, Cornell study in rats suggests
10. Training could remove racial bias from police reactions
11. Test could improve detection of prion disease in humans

Post Your Comments:
(Date:8/4/2015)... ... 04, 2015 , ... World Patent Marketing, a vertically integrated ... fitness invention that eliminates the need to have a partner or trainer when ... is worth $30 billion," says Scott Cooper, CEO and Creative Director of World ...
(Date:8/4/2015)... Birmingham, OH (PRWEB) , ... August 04, 2015 ... ... announce that it has joined the American Association of Tissue Banks (AATB) as ... AATB and its mission “to honor donors, and to save and improve lives ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... technology platform that uses Cloud innovation to consolidate oncology patient assistance programs. Through ... a single point of access. assistPoint is an enterprise level, cloud-based application and ...
(Date:8/4/2015)... ... August 04, 2015 , ... Atlantic Health System, one of the largest health ... among the top five in their list of the 20 Best Workplaces in Health ... Chilton Medical Centers, Goryeb Children’s Hospital and Atlantic Rehabilitation, is the highest-ranking company from ...
(Date:8/4/2015)... , ... August 04, 2015 , ... ... on sexual and reproductive health and rights in Indonesia for a select group ... a number of sites in Indonesia and attend the International Conference on Family ...
Breaking Medicine News(10 mins):Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 2Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 3Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 4Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 5Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 6Health News:Exsurco Medical Joins AATB as Affiliate Member 2Health News:assistPoint.com Web Site Launched 2Health News:Atlantic Health System Named a 'Best Workplace in Health Care' by Fortune, Great Place to Work® 2Health News:Atlantic Health System Named a 'Best Workplace in Health Care' by Fortune, Great Place to Work® 3Health News:Atlantic Health System Named a 'Best Workplace in Health Care' by Fortune, Great Place to Work® 4Health News:UN Foundation Announces Press Fellowship to Indonesia with Focus on Women’s Health and Rights 2
(Date:8/4/2015)... HeartWare International, Inc . (NASDAQ: ... circulatory support technologies that are revolutionizing the treatment of ... Chief Executive Officer, Doug Godshall , is scheduled ... Conference at 8:30 a.m. EDT on Thursday, August 13, ... at the InterContinental Boston. A live webcast ...
(Date:8/4/2015)... , Aug. 04, 2015 ... has announced the addition of the "MRI ... Comfort and Operational Efficiency, with Growth Driven by ... "MRI Systems Market to 2020 - Focus ... Driven by Developing Economies" discusses the market, competitive ...
(Date:8/4/2015)...  Dr. Keesha Ewers of The ... of flibanserin, or what is being touted as ... decreased female sexual desire back several decades. Diminished ... addressing libido as a singular symptom with a ... Photo - http://photos.prnewswire.com/prnh/20150804/254705 ...
Breaking Medicine Technology:HeartWare Presentation At The Canaccord Genuity 35th Annual Growth Conference To Be Webcast 2Global MRI Systems Market Outlook to 2020 - Focus on Patient Comfort and Operational Efficiency, with Growth Driven by Developing Economies 2Potential FDA Approval of "Pink Viagra" Sends Wrong Message 2Potential FDA Approval of "Pink Viagra" Sends Wrong Message 3Potential FDA Approval of "Pink Viagra" Sends Wrong Message 4Potential FDA Approval of "Pink Viagra" Sends Wrong Message 5
Cached News: