HOME >> MEDICINE >> NEWS
Ingredient in asthma inhaler drug may counteract inhaler benefits, according to Pittsburgh study

PITTSBURGH, March 23 An inactive agent, used in inhalers to treat asthma, can reverse the beneficial anti-inflammatory effects of inhaled steroids, according to a study presented today at the annual meeting of the American Academy of Allergy, Asthma and Immunology, in San Francisco, Calif.

Albuterol, in a class of medications called beta-agonists, is combined with steroids and is used to prevent and treat breathing problems caused by asthma and other lung diseases. It relaxes and opens the muscle surrounding air passages in the lungs, making it easier to breathe.

However, the study, presented by Williams Ameredes, Ph.D., research assistant professor of medicine and assistant professor of cell biology and physiology, in the division of pulmonary, allergy and critical care medicine at the University of Pittsburgh School of Medicine, may explain the paradoxical airway constriction and worsening of asthma in patients with continued use of beta-agonists.

"The research team of the Asthma, Allergy and Airway Research Center here at Pitt has had a long interest in mechanisms of beta-agonists, particularly due to the paradoxical responses to albuterol experienced by some asthmatics, that are severe enough to land them in the emergency department," Dr. Ameredes said.

"One potential explanation is that long-term repeated usage of albuterol may result in accumulation of the (S)- isomer of albuterol, which we know persists in the body 3-4 times longer than the beneficial (R)- isomer, which is normally metabolized in about three hours. Since the combination of steroid and beta-agonist therapy is prescribed for the long term for many asthmatics, we believed that it was reasonable to study the interaction of these compounds from the perspective of the isomers," he said.

Like other beta-agonists, chemically synthesized albuterol is typically called a "racemic" mixture. It is composed of 50 percent of the active version, or isomer, designated
'"/>


23-Mar-2004


Page: 1 2 3

Related medicine news :

1. Common Dental Bleaching Ingredient May Promote Growth Of Precancerous Oral Lesions, UB Dental Researchers Find
2. Exercise-induced shortness of breath not always caused by asthma
3. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
4. Why asthma sufferers struggle with the common cold
5. Use of inhaled corticosteroid led to fewer hospitalizations for young children with asthma
6. Cockroach allergens have greatest impact on childhood asthma in many US cities
7. Study finds indoor allergen levels vary, cockroach allergens cause more asthma symptoms
8. High levels of airborne mouse allergen in inner-city homes could trigger asthma attacks
9. African-Americans may need more medication to control asthma
10. New research could help physicians tailor asthma therapy in children
11. Supermarket bakery workers risk developing asthma

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/1/2020)... CYPRESS, Calif. (PRWEB) , ... April 02, 2020 ... ... Thursday, April 2, 2020, 3:00 pm PT/6:00 pm ET- to discuss surgical safety ... John Hopkins Hospital in Maryland, Louisiana State University Healthcare Network in New Orleans ...
(Date:4/1/2020)... YORK (PRWEB) , ... April 01, 2020 , ... ... protective equipment (PPE) to stay safe while treating Coronavirus-infected patients. , Staffers are ... sneezes that can transmit coronavirus. Earlier this week, The Wall Street Journal reported ...
(Date:4/1/2020)... ... April 01, 2020 , ... “Medical information ... California law,” says Keller Grover LLP attorney Eric A. Grover. “For that ... and the negligent release and disclosure of medical information can, under certain circumstances, ...
(Date:3/28/2020)... ... March 27, 2020 , ... Suntuity AirWorks ( ... companies, is mobilizing their drone equipment and training personnel to help towns and ... Enterprise level Matrice and Agras drones, Suntuity AirWorks is mobilizing their drone equipment ...
(Date:3/28/2020)... S.C. (PRWEB) , ... March 27, 2020 , ... ... orthopedic practice OrthoSC is now offering telemedicine as an alternative approach ... one of the practice’s doctors in the comfort of their own home or ...
Breaking Medicine News(10 mins):
(Date:3/30/2020)... England (PRWEB) , ... March 30, 2020 , ... ... government and business as part of their business continuity and thebigword is making ... , Clients of thebigword will be able to use the neural machine ...
(Date:3/27/2020)... ... ... Why a Podcast for Procap Medical Billing? , One of the main ... to explain more about what her business entails on a regular basis. There are ... the process of claim follow-up, conversing and networking with health care companies, and attaining ...
(Date:3/22/2020)... PHILADELPHIA (PRWEB) , ... March 21, 2020 , ... ... across the country, Temple University Hospital (TUH), its Department of Thoracic Medicine and ... staff and patients using HGE Health’s COVID Care symptom tracking platform and triage/care ...
Breaking Medicine Technology:
Cached News: