HOME >> MEDICINE >> NEWS
Inhibiting Growth Of New Blood Vessels Reduces Heart Disease Plaque In Mice

that require blood vessels in order to grow. These agents are also being investigated in studies of humans who have a type of sight-robbing macular degeneration associated with the proliferation of abnormal new blood vessels in the eye.

While angiogenesis inhibitors are being used in cancer and vision research studies, heart disease investigations are focusing on angiogenesis promoters. In the heart research, scientists are testing in humans certain genes and their protein products that promote angiogenesis. The goal of this research is to circumvent coronary arteries obstructed by the plaque deposits that characterize atherosclerosis, the disease process that causes heart disease.

Very tiny blood vessels called capillaries can grow from the artery wall and invade plaque. Whether these vessels promote plaque growth is uncertain. The Circulation paper provides the "most persuasive evidence to date" that these new blood vessels are a prerequisite for plaque expansion, says Jeffrey M. Isner, M.D., in an editorial accompanying the paper. Isner is chief of vascular medicine and cardiovascular research, department of medicine, St. Elizabeth's Medical Center, Boston, and professor of medicine and pathology, Tufts Medical School, Boston.

Does this evidence suggest that gene and protein treatments designed to promote angiogenesis in people with heart disease could result in the development of larger plaque in these individuals?

Recent human and animal studies on angiogenesis and heart disease have not revealed plaque growth as a result of these treatments, says Isner, one of several scientists conducting this type of research.

The mice in this experiment were fed a "Western diet," which is designed to mimic the cholesterol content of the typical diet eaten in the United States. The amount of plaque the mice developed was measured in the aorta, the large artery that carries blood from the heart to the rest of
'"/>

Contact: Carole Bullock
caroleb@heart.org
214-706-1279
American Heart Association
5-Apr-1999


Page: 1 2 3 4

Related medicine news :

1. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
2. Growth factor grows stem cells that help heal hearts
3. Growth hormone, sex steroid combination not ready for prime time
4. New Technique Induces Growth Across Spinal Cord Injury
5. Growth-Hormone Deficient Babies Are Normal Length At Birth, UB Study Finds
6. New Chemicals Could Lead To First Bone Growth Pill
7. Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors
8. Common Dental Bleaching Ingredient May Promote Growth Of Precancerous Oral Lesions, UB Dental Researchers Find
9. Clinical Trial Demonstrates Experimental Growth Factor Increases Eligibility For Autologous Stem Cell Transplantation
10. National Jewish Pediatric Asthma Specialist Urges Monitoring Growth When Using Nebulized Glucocorticoids As An Asthma Treatment In Children
11. Health Workers May Experience Costly Dislocation As Health Spending Growth Slows

Post Your Comments:
(Date:7/29/2014)... WA (PRWEB) July 29, 2014 Award-winning inventor ... , a flatulence neutralizer specifically designed to absorb embarrassing odors ... charcoal that can easily be stored in a desk drawer. ... use the PoofPad, users will simply sit on the pad ... gas at the office and then BAM, someone appears out ...
(Date:7/29/2014)... 2014 Riverdale Urgent Care is making ... Through their presence at local events, partnerships and other ... than just a medical service for the Riverdale neighborhood. ... in support of Riverdale RiverFest and South Riverdale Street ... features local musicians and entertainers, arts and crafts, boat ...
(Date:7/29/2014)... July 29, 2014 Lean and Lovely, an ... for women who want to wear a bikini in the ... Stevenson, prompting an investigative review. , “Our Lean and ... for women at all fitness levels. Neither your age nor ... unfit your body is at the beginning, you will achieve ...
(Date:7/29/2014)... Current Back2Basics long-term drug rehab resident Jon B. ... his first six months of sobriety. , This was ... foot, once on the other– which was how he became ... ago and was prescribed drugs that I didn’t take properly.” ... home who’d recently completed the program. The six-month long residential ...
(Date:7/29/2014)... 29, 2014 PeopleKeys today announced that ... teach students how to train and certify others in ... Behavioral Consultant Trainer , will be taught by PeopleKeys ... Training John Schindell as a live Tele-course over the ... The Certified Behavioral Consultant Trainer course will use a ...
Breaking Medicine News(10 mins):Health News:Award-Winning Inventor Michael Croix Launches an Indiegogo Campaign for PoofPad 2Health News:Award-Winning Inventor Michael Croix Launches an Indiegogo Campaign for PoofPad 3Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 2Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 3Health News:Lean and Lovely: Review Examining Neghar Fonooni’s Program Released 2Health News:Back2Basics Sober Living Resident Overcomes Obstacle in Early Sobriety 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 3
(Date:7/28/2014)... ORLANDO, Fla. , July 28, 2014 /PRNewswire/ ... "Company"), a biopharmaceutical company focused on the development, ... that it has filed definitive proxy materials with ... its 2014 Annual Meeting of Shareholders to be ... a.m., East Standard Time. The record date for ...
(Date:7/28/2014)... 2014 ResMed (NYSE: RMD ), ... cura dei disturbi respiratori del sonno (SDB) e altre ... in Germania contro il produttore Taiwanese di dispositivi medicali, ... apparecchiature da indossare in testa, che violano i brevetti, ... La sentenza della Corte Regionale Distrettuale di ...
(Date:7/28/2014)... (NYSE: RMD ), an innovator and pioneer ... and other chronic respiratory conditions, has won a permanent ... medical device manufacturer APEX Medical Corp. (APEX), prohibiting sales ... 220 masks.  The judgment was entered by the Regional ... appealable, and applies throughout Germany.  The ...
Breaking Medicine Technology:TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 3ResMed riceve un'ingiunzione permanente contro APEX in Germania, continua a far valere i propri diritti per i brevetti in Europa 2ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2
Cached News: