HOME >> MEDICINE >> NEWS
Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science

Washington D.C. - A team of Canadian scientists has identified a potentially useful target for drugs to treat type II diabetes and obesity. In the scientists' experiments, genetically engineered mice lacking a specific enzyme were able to resist weight gain and to avoid the decreased sensitivity to insulin that characterizes type II diabetes, even when fed an extremely high calorie, high fat diet. The results are reported in the 5 March issue of Science.

The finding raises hopes that researchers might someday design a drug for humans that mimics these effects by targeting the same enzyme. "It will certainly take some time to find a compound useful for humans based on our mouse model, but it has the possibility of being a really significant drug if it works," said Brian Kennedy of the Merck Frosst Center for Therapeutic Research in Pointe Claire-Dorval, Quebec, Canada, who was a member of the research team.

In 1995, there were 35 million cases of type II diabetes, or "non-insulin-dependent diabetes," worldwide, according to the World Health Organization, which predicts that the number will radically increase over the next 25 years. Type II diabetes usually develops gradually in people over 40, and overweight people are at particularly high risk for the disease. Diabetes occurs when the body's cells are unable to absorb enough blood sugar, or glucose, into their cells. This lack of cellular "fuel" and the high levels of glucose in the blood stream cause weight loss, fatigue, and a variety of long-term complications.

To store and use glucose, cells need assistance from the hormone insulin, which controls a complex series of steps to remove glucose from the bloodstream and sequester it in the cells. This set of steps is called the insulin "signal." People with type I diabetes (the more severe and early-onset form of the disease) do not produce insulin at all and must
'"/>

Contact: Gabriel Paal
gpaal@aaas.org
202-326-6421
American Association for the Advancement of Science
5-Mar-1999


Page: 1 2 3

Related medicine news :

1. Insulin resistance intervention after stroke focus of $33 million grant
2. Audio conference: Insulin resistance and polycystic ovary syndrome
3. Insulin pumps effective for children with diabetes
4. Insulin pump benefits preschoolers with diabetes
5. Insulin decreases inflammation, aids clot-busting drugs in heart attack patients, UB study shows
6. Insulin-producing cells found in a variety of tissues in diabetes
7. Insulin sensitizer has anti-inflammatory effect in diabetics
8. Insulin pump effective for infants, children
9. Insulin precursor linked with increased stroke risk; may represent new risk factor
10. Compound That Mimics Insulin Might Lead To Pill For Diabetes, As Reported In The 7 May Issue Of Science
11. Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/11/2019)... ... November 11, 2019 , ... Early praise for A ... down the complexities of scholarly writing and provides key insight and vital guidance for ... DNP Project will have a permanent place on my bookshelf and will be shared ...
(Date:11/11/2019)... Calif. (PRWEB) , ... November 11, 2019 , ... ... of business support services to dental groups in the United States, today announced ... the community of Lodi, CA. , Patients will enjoy convenient hours, comfortable offices ...
(Date:11/11/2019)... LAS VEGAS (PRWEB) , ... November 11, 2019 , ... ... buyers from 46 different countries including big box buyers like Costco, Walmart, and GNC. ... CBDfx, and GRN to name a few. , This year, CBD.io ...
(Date:11/11/2019)... ... November 11, 2019 , ... Artemis, ... prevention and urges increased adoption of compliance technology in the wake of the ... sold to select retailers in the United States and Canada due to potential ...
(Date:11/11/2019)... ... 11, 2019 , ... PracticeLink Live! Atlanta Physician Career Fair will take place ... 5:00 p.m. and continue until 8:00 p.m. A free, optional seminar for job-seeking physicians, ... 6:30 p.m. , Both the career fair and seminar are open to residents and ...
Breaking Medicine News(10 mins):
(Date:11/15/2019)... ... 15, 2019 , ... Mold doesn’t need things to be wet in order ... detectable to the eye or by touch. ServPro in Cayucos , the mold ... explaining the conditions that mold needs to grow and how to prevent those conditions. ...
(Date:11/14/2019)... ... 2019 , ... Researchers at Worcester Polytechnic Institute (WPI) are ... blood oxygen levels, a vital indication of the lungs’ effectiveness and whether the ... this miniaturized wearable device will be flexible and stretchable, wireless, inexpensive, and mobile—possibly ...
(Date:11/14/2019)... (PRWEB) , ... November 14, 2019 , ... ... K-FISH, aimed to promote the quality of Korean seafood and enhance its global ... entitled, "K-Seafood Global Weeks" in many countries. These special events are currently ...
Breaking Medicine Technology:
Cached News: