HOME >> MEDICINE >> NEWS
Insulin precursor linked with increased stroke risk; may represent new risk factor

DALLAS, Dec. 1 Researchers may have identified a new marker to spot individuals at risk of a first stroke, according to a study reported in the December issue of Stroke: Journal of the American Heart Association.

The substance, proinsulin, turns into insulin under the right conditions. Insulin is a hormone that helps the body use glucose and other energy sources. In this Swedish study, non-diabetic people with high levels of proinsulin had a sharply increased risk of first-time stroke especially women.

"High proinsulin concentration more than tripled the overall risk for first-ever stroke after adjusting for such risk factors as total cholesterol, high blood pressure, smoking, body mass index and insulin levels. And the risk for women was even more pronounced, says Bernt Lindahl, M.D., Ph.D., medical director of the Behavioral Medicine Clinic in the department of public health and clinical medicine, University Hospital of Northern Sweden.

The study found that non-diabetic men with the highest levels of proinsulin have more than a two-fold higher risk of stroke compared to men with the lowest levels. But for non-diabetic women the risk among those with the highest proinsulin levels is more than four times greater than for women with the lowest levels.

In women with both the highest diastolic blood pressure (the lower number in a blood pressure reading that represents the pressure between heart beats) and the highest levels of proinsulin, the risk of stroke jumps to nearly 20 times that of women in the studys lowest groups in both these categories, Lindahl adds.

"In the study, the diastolic blood pressure seems to be a stronger risk factor than the systolic blood pressure the higher number that represents the pressure during the heartbeat, he says.

Lindahl describes proinsulin as a "not fully matured form of insulin, a chemical substance produced by the pancreas to control the amount of sugar in the blood.


'"/>

Contact: Carole Bullock
caroleb@heart.org
214-706-1279
American Heart Association
29-Nov-2000


Page: 1 2 3

Related medicine news :

1. Insulin resistance intervention after stroke focus of $33 million grant
2. Audio conference: Insulin resistance and polycystic ovary syndrome
3. Insulin pumps effective for children with diabetes
4. Insulin pump benefits preschoolers with diabetes
5. Insulin decreases inflammation, aids clot-busting drugs in heart attack patients, UB study shows
6. Insulin-producing cells found in a variety of tissues in diabetes
7. Insulin sensitizer has anti-inflammatory effect in diabetics
8. Insulin pump effective for infants, children
9. Compound That Mimics Insulin Might Lead To Pill For Diabetes, As Reported In The 7 May Issue Of Science
10. Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
11. Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, ... formed by Walgreens and pharmacy benefit manager Prime Therapeutics ... new brand, which included the unveiling of new signage ... , as well as at a few other company-owned ... new brand to patients, some of whom will begin ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile app ... struggle to reverse the tide of prescription drug addiction. The ... their medicine intake and stepping down their dosage in a ... launch in December 2017; the first 100,000 people to sign ... at http://www.rebound-solution.com/ ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
Breaking Medicine Technology:
Cached News: