HOME >> MEDICINE >> NEWS
Insulin resistance intervention after stroke focus of $33 million grant

Researchers at Yale School of Medicine and over 60 collaborating research sites received a $33 million grant from the National Institutes of Neurological Disorders and Stroke (NINDS) to conduct a multi-center trial examining a novel approach for treating patients with stroke.

The Insulin Resistance Intervention after Stroke (IRIS) trial will study the effectiveness of a commonly-prescribed medication, pioglitazone, for preventing recurrent stroke and myocardial infarction among non-diabetic patients with a recent ischemic stroke and insulin resistance. The IRIS trial represents a novel approach to stroke prevention, addressing insulin resistance, a common, but often unrecognized risk factor.

Insulin resistance may lead to diabetes, stroke and myocardial infarction. By some estimates, insulin resistance affects up to 50 percent of stroke patients. The drug being tested, pioglitazone, reduces insulin resistance and is currently approved for use in diabetes treatment, but it has not been tested for prevention of vascular disease in non-diabetic patients.

Over 400,000 Americans survive an ischemic stroke each year. Stroke is the third leading cause of death in the United States. Despite current treatment, within four years of the initial event, 16 percent of stroke patients will have a recurrent stroke and 9 percent will have a myocardial infarction. "Prevention of further vascular events, therefore, is of major importance," said principal investigator Walter N. Kernan, M.D., associate professor of medicine at Yale School of Medicine.

The IRIS trial includes over 60 research centers in the United States and Canada that will recruit 3,136 participants in the next three years. Eligible participants are men and women age 45 or over without diabetes who have insulin resistance and a recent ischemic stroke. The participants will be randomly assigned to pioglitazone or placebo in addition to their usual therapy. "We have designed the trial to t
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
20-Jan-2005


Page: 1 2

Related medicine news :

1. Audio conference: Insulin resistance and polycystic ovary syndrome
2. Insulin pumps effective for children with diabetes
3. Insulin pump benefits preschoolers with diabetes
4. Insulin decreases inflammation, aids clot-busting drugs in heart attack patients, UB study shows
5. Insulin-producing cells found in a variety of tissues in diabetes
6. Insulin sensitizer has anti-inflammatory effect in diabetics
7. Insulin pump effective for infants, children
8. Insulin precursor linked with increased stroke risk; may represent new risk factor
9. Compound That Mimics Insulin Might Lead To Pill For Diabetes, As Reported In The 7 May Issue Of Science
10. Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
11. Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... ... February 19, 2019 , ... ... stigma in pregnant and postpartum women, a team led by a Worcester Polytechnic ... postpartum often show increased depressive symptoms, greater weight gain during pregnancy, and weight ...
(Date:2/19/2019)... ... February 19, 2019 , ... Landscape Structures Inc., a Delano, Minn.-based commercial ... to be a stunning and fun addition to any play space. Spinning is one ... Curva™ Spinners will provide kids’ brains with valuable equilibrium information. , Whether park and ...
(Date:2/19/2019)... ... February 19, 2019 , ... ... experience to The Oncology Institute of Hope and Innovation. , Dr. Lombardi completed ... cum laude. He received his medical degree from the University of Rochester School ...
(Date:2/19/2019)... ... February 19, 2019 , ... ClearHealth ... to Foley & Lardner LLP, as Recognized Consultants. The CHQI Recognized Consultant Program ... in pursuing CHQI accreditation. , Ms. Wein and Mr. Einhorn are part ...
(Date:2/19/2019)... Fla. (PRWEB) , ... February 18, 2019 , ... ... in the nation to test the PathO3Gen Solutions Footwear Sanitizing Stations to maximize ... Solestice 3/15 TechnologyTM to kill superbugs such as MRSA and C. difficile, which ...
Breaking Medicine News(10 mins):
(Date:2/19/2019)... (PRWEB) , ... February 19, ... ... and infrastructure solutions provider for global service providers, enterprises, and developers, announced ... orchestration platform with the Arvizio MR Studio mixed reality visualization and collaboration ...
(Date:2/19/2019)... ... February 19, 2019 , ... ... for Stage IV metastatic breast cancer (MBC), announces the opening of the 2019 ... Fairchild, “In honor of our 10-year anniversary, we are excited to announce we ...
(Date:2/19/2019)... ... February 19, 2019 , ... ... completed his new book “Live Hard Die Young.” Dr. Oexner was the first ... medicine, therapeutic exercise physiology, and nutritional counseling. Dr. Oexner was a supervisor on ...
Breaking Medicine Technology:
Cached News: