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Insulin resistance intervention after stroke focus of $33 million grant

Researchers at Yale School of Medicine and over 60 collaborating research sites received a $33 million grant from the National Institutes of Neurological Disorders and Stroke (NINDS) to conduct a multi-center trial examining a novel approach for treating patients with stroke.

The Insulin Resistance Intervention after Stroke (IRIS) trial will study the effectiveness of a commonly-prescribed medication, pioglitazone, for preventing recurrent stroke and myocardial infarction among non-diabetic patients with a recent ischemic stroke and insulin resistance. The IRIS trial represents a novel approach to stroke prevention, addressing insulin resistance, a common, but often unrecognized risk factor.

Insulin resistance may lead to diabetes, stroke and myocardial infarction. By some estimates, insulin resistance affects up to 50 percent of stroke patients. The drug being tested, pioglitazone, reduces insulin resistance and is currently approved for use in diabetes treatment, but it has not been tested for prevention of vascular disease in non-diabetic patients.

Over 400,000 Americans survive an ischemic stroke each year. Stroke is the third leading cause of death in the United States. Despite current treatment, within four years of the initial event, 16 percent of stroke patients will have a recurrent stroke and 9 percent will have a myocardial infarction. "Prevention of further vascular events, therefore, is of major importance," said principal investigator Walter N. Kernan, M.D., associate professor of medicine at Yale School of Medicine.

The IRIS trial includes over 60 research centers in the United States and Canada that will recruit 3,136 participants in the next three years. Eligible participants are men and women age 45 or over without diabetes who have insulin resistance and a recent ischemic stroke. The participants will be randomly assigned to pioglitazone or placebo in addition to their usual therapy. "We have designed the trial to t
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Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
20-Jan-2005


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