HOME >> MEDICINE >> NEWS
Insulin resistance intervention after stroke focus of $33 million grant

Researchers at Yale School of Medicine and over 60 collaborating research sites received a $33 million grant from the National Institutes of Neurological Disorders and Stroke (NINDS) to conduct a multi-center trial examining a novel approach for treating patients with stroke.

The Insulin Resistance Intervention after Stroke (IRIS) trial will study the effectiveness of a commonly-prescribed medication, pioglitazone, for preventing recurrent stroke and myocardial infarction among non-diabetic patients with a recent ischemic stroke and insulin resistance. The IRIS trial represents a novel approach to stroke prevention, addressing insulin resistance, a common, but often unrecognized risk factor.

Insulin resistance may lead to diabetes, stroke and myocardial infarction. By some estimates, insulin resistance affects up to 50 percent of stroke patients. The drug being tested, pioglitazone, reduces insulin resistance and is currently approved for use in diabetes treatment, but it has not been tested for prevention of vascular disease in non-diabetic patients.

Over 400,000 Americans survive an ischemic stroke each year. Stroke is the third leading cause of death in the United States. Despite current treatment, within four years of the initial event, 16 percent of stroke patients will have a recurrent stroke and 9 percent will have a myocardial infarction. "Prevention of further vascular events, therefore, is of major importance," said principal investigator Walter N. Kernan, M.D., associate professor of medicine at Yale School of Medicine.

The IRIS trial includes over 60 research centers in the United States and Canada that will recruit 3,136 participants in the next three years. Eligible participants are men and women age 45 or over without diabetes who have insulin resistance and a recent ischemic stroke. The participants will be randomly assigned to pioglitazone or placebo in addition to their usual therapy. "We have designed the trial to t
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
20-Jan-2005


Page: 1 2

Related medicine news :

1. Audio conference: Insulin resistance and polycystic ovary syndrome
2. Insulin pumps effective for children with diabetes
3. Insulin pump benefits preschoolers with diabetes
4. Insulin decreases inflammation, aids clot-busting drugs in heart attack patients, UB study shows
5. Insulin-producing cells found in a variety of tissues in diabetes
6. Insulin sensitizer has anti-inflammatory effect in diabetics
7. Insulin pump effective for infants, children
8. Insulin precursor linked with increased stroke risk; may represent new risk factor
9. Compound That Mimics Insulin Might Lead To Pill For Diabetes, As Reported In The 7 May Issue Of Science
10. Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
11. Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... EDWARDSVILLE, Ill. (PRWEB) , ... ... ... University Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and ... educated healthcare professionals on guideline updates for the primary prevention of cardiovascular ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology:
Cached News: