HOME >> MEDICINE >> NEWS
Insulin sensitizer has anti-inflammatory effect in diabetics

SAN FRANCISCO -- A drug used widely as an insulin sensitizer appears also to have a significant anti-inflammatory effect in diabetics, a property that could make it useful in helping to prevent heart disease in these patients, a study by endocrinologists at the University at Buffalo has found.

Results of the research, involving the drug rosiglitazone, were presented here today (June 15, 2002) at the annual meeting of the American Diabetes Association. Rosiglitazone is sold under the brand name Avandia(r).

UB endocrinologists, led by Paresh Dandona, M.D., professor of medicine and head of the Division of Endocrinology in the UB School of Medicine and Biomedical Sciences, have been studying the anti-inflammatory properties of insulin and insulin sensitizers and their potential use in treatment and prevention of atherosclerosis, one of the leading causes of heart attacks.

Atherosclerosis, or hardening of the arteries, begins as an inflammation of the blood-vessel wall. Persons with diabetes are at increased risk of developing atherosclerosis and heart disease. Dandona's lab has shown in research with a small group of obese non-diabetic volunteers that rosiglitazone decreased the levels of oxygen free radicals which can begin the inflammation cascade by injuring blood-vessel linings. The drug also decreased the levels of several blood markers of inflammation.

The current study involved 11 obese patients with Type 2 diabetes. In this disease, also referred to as adult-onset diabetes, the body produces adequate amounts of insulin, but cells don't respond to its action. Rosiglitazone is prescribed to break down this resistance to insulin.

Researchers collected blood samples from the diabetic volunteers and started them on a six-week course of daily rosiglitazone. They repeated the blood sampling four times during the six weeks of treatment and again at 12 weeks, and analyzed the samples for concentration of three inflammatory markers and fo
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
15-Jun-2002


Page: 1 2

Related medicine news :

1. Insulin resistance intervention after stroke focus of $33 million grant
2. Audio conference: Insulin resistance and polycystic ovary syndrome
3. Insulin pumps effective for children with diabetes
4. Insulin pump benefits preschoolers with diabetes
5. Insulin decreases inflammation, aids clot-busting drugs in heart attack patients, UB study shows
6. Insulin-producing cells found in a variety of tissues in diabetes
7. Insulin pump effective for infants, children
8. Insulin precursor linked with increased stroke risk; may represent new risk factor
9. Compound That Mimics Insulin Might Lead To Pill For Diabetes, As Reported In The 7 May Issue Of Science
10. Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
11. Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insulin sensitizer has anti inflammatory effect diabetics

(Date:7/29/2014)... Premier Women’s Health , a six-physician ... has affiliated with Allegheny Health Network’s renowned Women’s Health ... babies and perform surgical procedures at Heritage Valley Sewickley. ... referred to Allegheny Health Network’s West Penn Hospital ... West Penn Hospital and its highly regarded Women’s Health ...
(Date:7/29/2014)... Boca Raton, FL (PRWEB) July 29, 2014 ... will officially launch its products in the UK in September. ... company’s products will be available Sept. 7 on Amazon.co.uk. , ... has been growing and we are truly looking forward to ... Amazon.co.uk will include OZ Naturals bestselling Vitamin C serum ...
(Date:7/29/2014)... 29, 2014 Representatives with BNatrl announced ... called BNatrl Silver Solution 12ppm . , “It’s ... spokesperson for BNatrl LLC. “It helps boost your immune ... harmful pathogens and microbes.” , BNatrl develops and manufactures ... products, with 10 percent of profits being used to ...
(Date:7/29/2014)... IsoComforter, Inc ., one of the ... the introduction of the innovative new Iso-Hip Wrap. ... for post operative hip replacement patients. The plush design ... benefits of cold therapy while resting, sitting, or standing. ... are done every year. Cold therapy is the ...
(Date:7/29/2014)... July 29, 2014 Regents Health Resources, ... services, has brought health care industry veteran Daryl Demonbreun ... to help lead the company’s ambitious plans to grow ... Health has been moving along at a steady pace ... it up a notch,” says Bob Maier, founder and ...
Breaking Medicine News(10 mins):Health News:Leading West Suburban OBGYN Practice, Premier Women’s Health, Joins Allegheny Health Network 2Health News:Leading West Suburban OBGYN Practice, Premier Women’s Health, Joins Allegheny Health Network 3Health News:OZ Naturals to Launch Its Products in the UK 2Health News:BNatrl Launches New Silver Solution Product 2Health News:New IsoComforter Cold Therapy Unit Plus Hip Wrap Gives Post Operative Hip Replacement Patients Faster Recovery Times 2Health News:Sferrella and Demonbruen Join Regents Health Resources 2
(Date:7/29/2014)... , July 29, 2014 ... Market Research "Orthopedic Trauma Fixation Devices Market - Global ... - 2020", the global orthopedic trauma fixation devices market ... is expected to grow at a CAGR of 7.2% ... of USD 9.3 billion in 2020. Browse ...
(Date:7/29/2014)... -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... 2014 financial results after the Nasdaq market closes on ... live conference call and webcast to discuss its financial ... 7, 2014 at 8:00 a.m. Eastern Time (5:00 a.m. ... conference call by dialing 866-952-1907 (US) or 785-424-1826 (International) ...
(Date:7/29/2014)... July 29, 2014  Instrumentation Laboratory (IL) today announced the ... corporate logo. This is part of a comprehensive rebranding effort ... in Boston, MA , in 1959, IL ... since 1992.  Other companies in the group include Inova Diagnostics ... ( Barcelona, Spain ).  Like IL, these three ...
Breaking Medicine Technology:Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 4Neurocrine Biosciences Announces Conference Call And Webcast To Report Second Quarter 2014 Financial Results 2Instrumentation Laboratory Unveils New Corporate Brand 2Instrumentation Laboratory Unveils New Corporate Brand 3
Cached News: